Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine). (Q43919081)

28 November 2017

title

Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine). (English)

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28 November 2017

Saori Sato

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28 November 2017

Naoya Fujita

series ordinal

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28 November 2017

Takashi Tsuruo

series ordinal

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28 November 2017

language of work or name

English

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publication date

1 March 2002

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28 November 2017

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28 November 2017

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28 November 2017

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28 November 2017

page(s)

1727-1738

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UCN-01 (7-hydoxystaurosporine) inhibits in vivo growth of human cancer cells through selective perturbation of G1 phase checkpoint machinery

28 November 2017

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Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

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Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase

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Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

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Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons

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7 January 2021

Acceleration of apoptotic cell death after the cleavage of Bcl-XL protein by caspase-3-like proteases

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Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

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Pharmacokinetics and pharmacodynamics of a novel protein kinase inhibitor, UCN-01

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7 January 2021

7-Hydroxystaurosporine (UCN-01) Induces Apoptosis in Human Colon Carcinoma and Leukemia Cells Independently of p53

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7 January 2021

UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

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UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities

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7 January 2021

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

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7 January 2021

The correction for bias in prevalence estimation with screening tests.

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205225

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Dimensions Publication ID

28 November 2017

1049957033

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