Activation of the PI3K/Akt pathway and chemotherapeutic resistance (Q35046899)

6 August 2017

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title

Activation of the PI3K/Akt pathway and chemotherapeutic resistance (English)

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6 August 2017

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Kip A West

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6 August 2017

S Sianna Castillo

series ordinal

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6 August 2017

Phillip A Dennis

series ordinal

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6 August 2017

publication date

1 December 2002

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6 August 2017

published in

Drug Resistance Updates

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

234-248

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Delayed mammary gland involution in MMTV-AKT1 transgenic mice

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Immunohistochemical localization of phosphorylated AKT in multiple myeloma

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFR-positive cancer cell lines with or without erbB2 overexpression

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Oncogenic kinase signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Mechanisms of enhancement of cytotoxicity in etoposide and ionising radiation-treated cells by the protein kinase inhibitor wortmannin

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Cell cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through phosphatidylinositol 3-kinase and mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

The phosphoinositide 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

G1 phase arrest by the phosphatidylinositol 3-kinase inhibitor LY 294002 is correlated to up-regulation of p27Kip1 and inhibition of G1 CDKs in choroidal melanoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Role of X-linked inhibitor of apoptosis protein in chemoresistance in ovarian cancer: possible involvement of the phosphoinositide-3 kinase/Akt pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Hydrogen peroxide-mediated phosphorylation of ERK1/2, Akt/PKB and JNK in cortical neurones: dependence on Ca(2+) and PI3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Cellular survival: a play in three Akts

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: requirement for Akt activation

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Impaired Fas response and autoimmunity in Pten+/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

TEL/platelet-derived growth factor receptor beta activates phosphatidylinositol 3 (PI3) kinase and requires PI3 kinase to regulate the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

CREB is a regulatory target for the protein kinase Akt/PKB

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Differential modulation of signaling pathways and apoptosis of ras-transformed 10T1/2 cells by the depsipeptide FR901228.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Suppression of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated aryl hydrocarbon receptor transformation and CYP1A1 induction by the phosphatidylinositol 3-kinase inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1- benzopyran-4-one (LY294002).

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

D-21266, a new heterocyclic alkylphospholipid with antitumour activity

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Inhibition of protein kinase B/Akt. implications for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

The AKT kinase is activated in multiple myeloma tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

3-Deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Mechanisms of resistance to rapamycins

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Potentiation of chemosensitivity in multidrug-resistant human leukemia CEM cells by inhibition of DNA-dependent protein kinase using wortmannin

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Black tea polyphenols inhibit IGF-I-induced signaling through Akt in normal prostate epithelial cells and Du145 prostate carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Phosphoinositide-regulated kinases and phosphoinositide phosphatases.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

The role of protein kinase B (PKB) in modulating heat sensitivity in a human breast cancer cell line

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Cellular response to oxidative stress: signaling for suicide and survival

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

High expression levels of nuclear factor kappaB, IkappaB kinase alpha and Akt kinase in squamous cell carcinoma of the oral cavity

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Akt, MAPK (Erk1/2), and p38 act in concert to promote apoptosis in response to ErbB receptor family inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

The protein kinase B/Akt signalling pathway in human malignancy

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Induction of ovarian cancer by defined multiple genetic changes in a mouse model system

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Differential phosphorylation at Ser473 and Thr308 of Akt-1 in rat brain following hypoglycemic coma

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Expression of Active Protein Kinase B in T Cells Perturbs Both T and B Cell Homeostasis and Promotes Inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

The phosphoinositide 3-kinase/Akt pathway is activated by daunorubicin in human acute myeloid leukemia cell lines.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

3-Deoxy-D-myo-inositol 1-phosphate, 1-phosphonate, and ether lipid analogues as inhibitors of phosphatidylinositol-3-kinase signaling and cancer cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Molecular modeling studies of the Akt PH domain and its interaction with phosphoinositides

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Induction of phosphatidylinositol 3-kinase and serine-threonine kinase-like immunoreactivity in rabbit spinal cord after transient ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Epidermal growth factor-related peptides and their receptors in human malignancies

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Role of phosphatidylinositol-3-kinase in insulin receptor signaling: studies with inhibitor, LY294002.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

TOR, a central controller of cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Functional roles of Akt signaling in mouse skin tumorigenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

AKT plays a central role in tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Cellular signaling: pivoting around PDK-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Signaling by distinct classes of phosphoinositide 3-kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

The PI3K-PDK1 connection: more than just a road to PKB

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Water-soluble HPMA copolymer-wortmannin conjugate retains phosphoinositide 3-kinase inhibitory activity in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

PTEN augments staurosporine-induced apoptosis in PTEN-null Ishikawa cells by downregulating PI3K/Akt signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900120-6

7 January 2021

10.1016/S1368-7646(02)00120-6

Identifiers

DOI

1 reference

6 August 2017

1 reference