The application of siRNA technology to cancer biology discovery (Q36680074)

15 August 2017

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title

The application of siRNA technology to cancer biology discovery (English)

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15 August 2017

Uta Fuchs

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15 August 2017

Arndt Borkhardt

series ordinal

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15 August 2017

publication date

1 January 2007

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Advances in Cancer Research

15 August 2017

published in

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15 August 2017

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15 August 2017

page(s)

75-102

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Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

15 August 2017

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Silencing of the HER2/neu gene by siRNA inhibits proliferation and induces apoptosis in HER2/neu-overexpressing breast cancer cells.

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Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

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7 January 2021

Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells

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7 January 2021

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Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex.

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CRD-BP/IMP1 expression characterizes cord blood CD34+ stem cells and affects c-myc and IGF-II expression in MCF-7 cancer cells

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Iterative microarray and RNA interference-based interrogation of the SRC-induced invasive phenotype

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7 January 2021

Expression profiling reveals off-target gene regulation by RNAi

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7 January 2021

RNA silencing of S-phase kinase-interacting protein 2 inhibits proliferation and centrosome amplification in lung cancer cells

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7 January 2021

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

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7 January 2021

The concept of synthetic lethality in the context of anticancer therapy

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7 January 2021

Discovery of transdermal penetration enhancers by high-throughput screening

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7 January 2021

Transfection microarray of nonadherent cells on an oleyl poly(ethylene glycol) ether-modified glass slide

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7 January 2021

Induction of DNA methylation and gene silencing by short interfering RNAs in human cells

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7 January 2021

Heritable gene silencing in Drosophila using double-stranded RNA.

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A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity

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The activity of siRNA in mammalian cells is related to structural target accessibility: a comparison with antisense oligonucleotides

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7 January 2021

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7 January 2021

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7 January 2021

Use of adenovirus-delivered siRNA to target oncoprotein p28GANK in hepatocellular carcinoma.

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7 January 2021

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7 January 2021

Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells

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7 January 2021

Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

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7 January 2021

Gene therapy. Second child in French trial is found to have leukemia

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7 January 2021

RISC is a 5' phosphomonoester-producing RNA endonuclease

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7 January 2021

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7 January 2021

Mechanisms of gene silencing by double-stranded RNA

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7 January 2021

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

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7 January 2021

Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity

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7 January 2021

Production of aberrant promoter transcripts contributes to methylation and silencing of unlinked homologous promoters in trans

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7 January 2021

U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells.

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7 January 2021

Comparison of the Suppressive Effects of Antisense Oligonucleotides and siRNAs Directed Against the Same Targets in Mammalian Cells

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7 January 2021

Generation of an shRNAi expression library against the whole human transcripts

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7 January 2021

Small interfering RNA-induced transcriptional gene silencing in human cells

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7 January 2021

RNAi microarray analysis in cultured mammalian cells

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7 January 2021

An unusually compact external promoter for RNA polymerase III transcription of the human H1RNA gene

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7 January 2021

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

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7 January 2021

High-throughput RNAi screening in vitro: from cell lines to primary cells.

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7 January 2021

RNA interference: the new somatic cell genetics?

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7 January 2021

Stable suppression of gene expression by RNAi in mammalian cells

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7 January 2021

RNA silencing: the genome's immune system

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7 January 2021

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7 January 2021

RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin.

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7 January 2021

Receptor-targeted siRNAs

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7 January 2021

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7 January 2021

RNAi: gene-silencing in therapeutic intervention

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RNA interference microarrays: high-throughput loss-of-function genetics in mammalian cells

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Activation of the interferon system by short-interfering RNAs

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7 January 2021

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7 January 2021

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7 January 2021

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

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7 January 2021

Cancer inhibition in nude mice after systemic application of U6 promoter-driven short hairpin RNAs against PLK1.

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7 January 2021

Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells

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7 January 2021

How cells respond to interferons

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7 January 2021

Stable and complete overcoming of MDR1/P-glycoprotein-mediated multidrug resistance in human gastric carcinoma cells by RNA interference

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7 January 2021

Retroviruses in foreign species and the problem of provirus silencing

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7 January 2021

The rde-1 gene, RNA interference, and transposon silencing in C. elegans

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7 January 2021

RNAi technology and lentiviral delivery as a powerful tool to suppress Tpr-Met-mediated tumorigenesis.

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7 January 2021

Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells.

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7 January 2021

A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA.

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7 January 2021

Selecting protein tyrosine phosphatases as drug targets

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7 January 2021

Functional genomics using high-throughput RNA interference

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7 January 2021

Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis

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7 January 2021

RNA silencing as a plant immune system against viruses

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7 January 2021

Live or let die: the cell's response to p53

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7 January 2021

Knockdown of c-Myc expression by RNAi inhibits MCF-7 breast tumor cells growth in vitro and in vivo

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7 January 2021

Targeting the kinesin Eg5 to monitor siRNA transfection in mammalian cells

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7 January 2021

Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation

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7 January 2021

V599EB-RAF is an oncogene in melanocytes

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7 January 2021

A genetic screen for candidate tumor suppressors identifies REST

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7 January 2021

Cell microarrays and RNA interference chip away at gene function

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7 January 2021

Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi).

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7 January 2021

RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells

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7 January 2021

Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1.

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7 January 2021

Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571).

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7 January 2021

A novel approach for evaluating the efficiency of siRNAs on protein levels in cultured cells

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7 January 2021

Complete reversal of multidrug resistance by stable expression of small interfering RNAs targeting MDR1.

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7 January 2021

Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer

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7 January 2021

siRNA-based inhibition specific for mutant SOD1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme

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7 January 2021

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

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7 January 2021

MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms

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7 January 2021

P53 in cancer: a paradigm for modern management of cancer

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7 January 2021

10.1016/S0065-230X(06)96004-7

Identifiers

DOI

1 reference

15 August 2017

1 reference