Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94 (Q35899122)

11 August 2017

Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94 (English)

1 reference

11 August 2017

endoplasmic reticulum

0 references

Gabriela Chiosis

0 references

Pengrong Yan

0 references

Hardik J Patel

1 reference

11 August 2017

Pallav D Patel

1 reference

11 August 2017

Stefan O Ochiana

1 reference

11 August 2017

Weilin Sun

1 reference

11 August 2017

Maulik R Patel

1 reference

11 August 2017

Smit K Shah

1 reference

11 August 2017

Elisa Tramentozzi

1 reference

11 August 2017

James Brooks

1 reference

11 August 2017

Alexander Bolaender

1 reference

11 August 2017

Liza Shrestha

1 reference

11 August 2017

Ralph Stephani

1 reference

11 August 2017

Paola Finotti

1 reference

11 August 2017

Cynthia Leifer

1 reference

11 August 2017

Zihai Li

1 reference

11 August 2017

Daniel T Gewirth

1 reference

11 August 2017

Tony Taldone

1 reference

11 August 2017

language of work or name

English

0 references

publication date

22 April 2015

1 reference

Journal of Medicinal Chemistry

11 August 2017

1 reference

11 August 2017

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11 August 2017

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11 August 2017

3922-3943

1 reference

describes a project that uses

11 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4518544/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma

11 July 2018

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Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directions

11 July 2018

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11 July 2018

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Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors

11 July 2018

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Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma

11 July 2018

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Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

11 July 2018

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Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series

11 July 2018

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Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors

11 July 2018

1 reference

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Development of a Grp94 inhibitor

11 July 2018

1 reference

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Heat shock protein gp96 regulates Toll-like receptor 9 proteolytic processing and conformational stability

11 July 2018

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Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment

11 July 2018

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GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum

11 July 2018

1 reference

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Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

11 July 2018

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TRAP-1, the mitochondrial Hsp90.

11 July 2018

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A systematic protocol for the characterization of Hsp90 modulators.

11 July 2018

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A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas

11 July 2018

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CUDC-305, a novel synthetic HSP90 inhibitor with unique pharmacologic properties for cancer therapy

11 July 2018

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Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

11 July 2018

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Different Poses for Ligand and Chaperone in Inhibitor-Bound Hsp90 and GRP94: Implications for Paralog-Specific Drug Design

11 July 2018

1 reference

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The chaperone activity of GRP94 toward insulin-like growth factor II is necessary for the stress response to serum deprivation

11 July 2018

1 reference

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Microwave-assisted one step synthesis of 8-arylmethyl-9H-purin-6-amines

11 July 2018

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Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network.

11 July 2018

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Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer

11 July 2018

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Heat shock protein 90: the cancer chaperone

11 July 2018

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Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages

11 July 2018

1 reference

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Chaperoning oncogenes: Hsp90 as a target of geldanamycin.

11 July 2018

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Orally active purine-based inhibitors of the heat shock protein 90.

11 July 2018

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Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.

11 July 2018

1 reference

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HSP90 and the chaperoning of cancer

11 July 2018

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Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.

11 July 2018

1 reference

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A small molecule-kinase interaction map for clinical kinase inhibitors

11 July 2018

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Design, synthesis, and evaluation of a radicicol and geldanamycin chimera, radamide

11 July 2018

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Ligand-induced conformational shift in the N-terminal domain of GRP94, an Hsp90 chaperone

11 July 2018

1 reference

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Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening

11 July 2018

1 reference

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Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

11 July 2018

1 reference

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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4518544

Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4518544

Medicinal chemistry of adenosine A2A receptor agonists

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4518544

Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4518544

Toll-like receptors and innate immunity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4518544

Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4518544

The glucose-regulated protein grp94 is related to heat shock protein hsp90.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4518544

Targeting heat shock protein 90 with non-quinone inhibitors: a novel chemotherapeutic approach in human hepatocellular carcinoma.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4518544

TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptotis in human colorectal carcinoma cells

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4518544

3D QSAR and molecular docking studies of benzimidazole derivatives as hepatitis C virus NS5B polymerase inhibitors

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4518544

Synthesis of a red-shifted fluorescence polarization probe for Hsp90.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4518544

Structure of unliganded GRP94, the endoplasmic reticulum Hsp90. Basis for nucleotide-induced conformational change

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4518544

General method for the synthesis of 8-arylsulfanyl adenine derivatives

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4518544

Structural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25901531

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone, GRP94. I. Evidence for allosteric regulation of ligand binding

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25901531

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ACS.JMEDCHEM.5B00197

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

25901531

1 reference