Heat shock protein 90: the cancer chaperone (Q36834685)

16 August 2017

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title

Heat shock protein 90: the cancer chaperone (English)

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16 August 2017

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Len Neckers

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16 August 2017

publication date

1 April 2007

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16 August 2017

published in

Journal of Biosciences

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16 August 2017

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16 August 2017

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16 August 2017

page(s)

517-530

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HSP90 interacts with and regulates the activity of heat shock factor 1 in Xenopus oocytes

16 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS12038-007-0051-Y

17AAG: low target binding affinity and potent cell activity--finding an explanation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12038-007-0051-Y

Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12038-007-0051-Y

Use of methotrexate-based peptide substrates to characterize the substrate specificity of prostate-specific membrane antigen (PSMA).

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12038-007-0051-Y

Inhibition of Hsp90: a new strategy for inhibiting protein kinases

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12038-007-0051-Y

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12038-007-0051-Y

Out of air is not out of action

21 January 2018

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12 December 2020

Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity.

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12 December 2020

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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12 December 2020

Rational design of shepherdin, a novel anticancer agent.

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12 December 2020

Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies

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12 December 2020

Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase

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12 December 2020

RET and neuroendocrine tumors

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12 December 2020

Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats

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12 December 2020

17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts

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12 December 2020

Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila.

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12 December 2020

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12 December 2020

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors

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12 December 2020

Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury.

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12 December 2020

Geldanamycin induces heat shock protein expression through activation of HSF1 in K562 erythroleukemic cells

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12 December 2020

Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)

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12 December 2020

Development of Purine-Scaffold Small Molecule Inhibitors of Hsp90

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12 December 2020

Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity.

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12 December 2020

Aggresome formation in liver cells in response to different toxic mechanisms: role of the ubiquitin-proteasome pathway and the frameshift mutant of ubiquitin

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12 December 2020

Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.

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12 December 2020

Protein ubiquitination in rat brain following hypoglycemic coma

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12 December 2020

Mechanism of antiandrogen action: key role of hsp90 in conformational change and transcriptional activity of the androgen receptor

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12 December 2020

Genes in familial parkinsonism and their role in sporadic Parkinson's disease.

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12 December 2020

Modelling the molecular circuitry of cancer

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12 December 2020

VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition

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12 December 2020

Glutamine repeats and neurodegeneration

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12 December 2020

17-Allylamino-17-demethoxygeldanamycin (17-AAG) is effective in down-regulating mutated, constitutively activated KIT protein in human mast cells

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12 December 2020

Hsp90: the vulnerable chaperone

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12 December 2020

Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design

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12 December 2020

Metabolism of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) by murine and human hepatic preparations.

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12 December 2020

Update on . . . the proteasome inhibitor PS341

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12 December 2020

Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer.

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12 December 2020

Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia

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12 December 2020

Protein aggregation after transient cerebral ischemia.

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12 December 2020

Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins

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12 December 2020

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

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12 December 2020

BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90.

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12 December 2020

Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells

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12 December 2020

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

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12 December 2020

The Hallmarks of Cancer

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12 December 2020

Molecular sequelae of proteasome inhibition in human multiple myeloma cells

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12 December 2020

Hsp90 inhibitors as novel cancer chemotherapeutic agents

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12 December 2020

Structure and functional relationships of Hsp90.

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12 December 2020

Induction of Hsp90 protein expression in malignant melanomas and melanoma metastases

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12 December 2020

V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors

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12 December 2020

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

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12 December 2020

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

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12 December 2020

Altered Hsp90 function in cancer: a unique therapeutic opportunity.

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12 December 2020

Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle

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12 December 2020

Hsp90 as a capacitor for morphological evolution

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12 December 2020

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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12 December 2020

Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation

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12 December 2020

A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies

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12 December 2020

The Hsp90 chaperone complex as a novel target for cancer therapy

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12 December 2020

Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma

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12 December 2020

Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone

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12 December 2020

Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors

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12 December 2020

The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome

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12 December 2020

Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

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12 December 2020

Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.

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12 December 2020

Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228

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12 December 2020

Activity of suberoylanilide hydroxamic Acid against human breast cancer cells with amplification of her-2.

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12 December 2020

Hsp70 and Hsp90--a relay team for protein folding

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12 December 2020

Hypoxia--a key regulatory factor in tumour growth

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12 December 2020

Molecular characterization and sensitivity of STI-571 (imatinib mesylate, Gleevec)-resistant, Bcr-Abl-positive, human acute leukemia cells to SRC kinase inhibitor PD180970 and 17-allylamino-17-demethoxygeldanamycin.

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12 December 2020

Heat shock protein 90 as a molecular target for cancer therapeutics

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12 December 2020

RAF/RAS oncogenes and mismatch-repair status

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12 December 2020

NAD(P)H:quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues

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12 December 2020

Targeting multiple signal transduction pathways through inhibition of Hsp90.

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12 December 2020

Physiologically-Based Pharmacokinetics and Molecular Pharmacodynamics of 17-(allylamino)-17-demethoxygeldanamycin and Its Active Metabolite in Tumor-Bearing Mice

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12 December 2020

erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships

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12 December 2020

Extracellular roles for the molecular chaperone, hsp90.

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12 December 2020

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

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12 December 2020

Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol

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12 December 2020

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12 December 2020

Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts

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12 December 2020

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12 December 2020

Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin

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12 December 2020

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

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12 December 2020

Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent

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12 December 2020

Insights from pre-clinical studies for new combination treatment regimens with the Bcr-Abl kinase inhibitor imatinib mesylate (Gleevec/Glivec) in chronic myelogenous leukemia: a translational perspective.

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12 December 2020

Molecular mechanisms of RET activation in human cancer.

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12 December 2020

A Drosophila model of Parkinson's disease

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12 December 2020

Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition

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12 December 2020

Effect of geldanamycin on androgen receptor function and stability

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12 December 2020

Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness

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12 December 2020

Toxic proteins in neurodegenerative disease

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12 December 2020

Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia

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12 December 2020

Heat-shock protein 90 inhibitors in antineoplastic therapy: is it all wrapped up?

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12 December 2020

Cancer robustness: Tumour tactics

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12 December 2020

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

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12 December 2020

Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone

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12 December 2020

Inhibition of medullary thyroid carcinoma cell proliferation and RET phosphorylation by tyrosine kinase inhibitors

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12 December 2020

FLT3 tyrosine kinase as a target molecule for selective antileukemia therapy

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12 December 2020

DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

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12 December 2020

Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex

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12 December 2020

Hsp90 as a capacitor of phenotypic variation

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12 December 2020

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

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12 December 2020

Protein misfolding and prion diseases

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12 December 2020

Protein precipitation: a common etiology in neurodegenerative disorders?

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12 December 2020

Pharmacological prevention of Parkinson disease in Drosophila.

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12 December 2020

Alpha-synuclein dysfunction in Lewy body diseases

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12 December 2020

Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.

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12 December 2020

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

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12 December 2020

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

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12 December 2020

Geldanamycin, a new antibiotic

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12 December 2020

Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells

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12 December 2020

Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study.

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12 December 2020

The onset and extent of genomic instability in sporadic colorectal tumor progression

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12 December 2020

Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion

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12 December 2020

The RET proto-oncogene in human cancers

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12 December 2020

10.1007/S12038-007-0051-Y

Identifiers

DOI

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16 August 2017

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