Selective targeting of the stress chaperome as a therapeutic strategy (Q28248791)

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Language	Label	Description	Also known as
English	Selective targeting of the stress chaperome as a therapeutic strategy	scientific article

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instance of

scholarly article

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review article

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stated in

Europe PubMed Central

title

Selective targeting of the stress chaperome as a therapeutic strategy (English)

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author

Gabriela Chiosis

series ordinal

4

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Tony Taldone

series ordinal

1

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author name string

Stefan O Ochiana

series ordinal

2

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Pallav D Patel

series ordinal

3

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language of work or name

English

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publication date

November 2014

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published in

Trends in Pharmacological Sciences

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volume

35

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issue

11

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page(s)

592-603

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cites work

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Inhibition of heat shock protein 90 alleviates steatosis and macrophage activation in murine alcoholic liver injury

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Modulation of the Hsp90 chaperone cycle by a stringent client protein

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ATPase activity and ATP-dependent conformational change in the co-chaperone HSP70/HSP90-organizing protein (HOP)

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HspB1, HspB5 and HspB4 in Human Cancers: Potent Oncogenic Role of Some of Their Client Proteins

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Chronic treatment with 17-DMAG improves balance and coordination in a new mouse model of Machado-Joseph disease

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29 September 2017

Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein

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29 September 2017

Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition

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29 September 2017

HSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.

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Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma

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Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

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29 September 2017

Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series

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29 September 2017

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies

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29 September 2017

Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease

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29 September 2017

Analysis of conformational determinants underlying HSP90-kinase interaction

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29 September 2017

Hsp90 inhibitor 17-DMAG decreases expression of conserved herpesvirus protein kinases and reduces virus production in Epstein-Barr virus-infected cells

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29 September 2017

Structure, function and regulation of the hsp90 machinery

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29 September 2017

Molecular chaperone functions in protein folding and proteostasis

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29 September 2017

Hsp110 is a bona fide chaperone using ATP to unfold stable misfolded polypeptides and reciprocally collaborate with Hsp70 to solubilize protein aggregates.

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29 September 2017

Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity

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29 September 2017

Genome-wide functional screening identifies CDC37 as a crucial HSP90-cofactor for KIT oncogenic expression in gastrointestinal stromal tumors

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29 September 2017

The HSP70 family and cancer

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29 September 2017

ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system

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29 September 2017

A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity

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29 September 2017

Hsp60, a novel target for antitumor therapy: structure-function features and prospective drugs design

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29 September 2017

Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B.

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29 September 2017

A prescription for 'stress'--the role of Hsp90 in genome stability and cellular adaptation

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29 September 2017

The odyssey of Hsp60 from tumor cells to other destinations includes plasma membrane-associated stages and Golgi and exosomal protein-trafficking modalities

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29 September 2017

Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer.

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29 September 2017

Tumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy

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29 September 2017

Development of a Grp94 inhibitor

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29 September 2017

Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment

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29 September 2017

Heat shock protein 90 inhibitors as therapeutic agents

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29 September 2017

Hsp90 molecular chaperone inhibitors: are we there yet?

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29 September 2017

A potentially common peptide target in secreted heat shock protein-90α for hypoxia-inducible factor-1α-positive tumors

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29 September 2017

The heat shock protein 90 inhibitor, AT13387, displays a long duration of action in vitro and in vivo in non-small cell lung cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254259

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29 September 2017

Quantitative proteomics reveals that Hsp90 inhibition preferentially targets kinases and the DNA damage response

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254259

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29 September 2017

Broad action of Hsp90 as a host chaperone required for viral replication

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254259

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29 September 2017

A small molecule that binds to an ATPase domain of Hsc70 promotes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254259

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29 September 2017

Preclinical antitumor activity of the novel heat shock protein 90 inhibitor CH5164840 against human epidermal growth factor receptor 2 (HER2)-overexpressing cancers

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PubMed Central

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29 September 2017

Heterogeneity and dynamics in the assembly of the heat shock protein 90 chaperone complexes

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PubMed Central

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29 September 2017

Human DNAJ in cancer and stem cells

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PubMed Central

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29 September 2017

HSP70s: From Tumor Transformation to Cancer Therapy.

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29 September 2017

Expanding the cellular molecular chaperone network through the ubiquitous cochaperones

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254259

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29 September 2017

TRAP-1, the mitochondrial Hsp90.

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254259

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29 September 2017

Post-translational modifications of Hsp90 and their contributions to chaperone regulation

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PubMed Central

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29 September 2017

Conformational dynamics of the molecular chaperone Hsp90

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29 September 2017

Chemical Screens against a Reconstituted Multiprotein Complex: Myricetin Blocks DnaJ Regulation of DnaK through an Allosteric Mechanism

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29 September 2017

A systematic protocol for the characterization of Hsp90 modulators.

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PubMed Central

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29 September 2017

Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800.

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254259

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29 September 2017

Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254259

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29 September 2017

A small molecule inhibitor of inducible heat shock protein 70.

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PubMed Central

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29 September 2017

Expression of Hsp90 chaperone [corrected] proteins in human tumor tissue

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PubMed Central

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29 September 2017

CUDC-305, a novel synthetic HSP90 inhibitor with unique pharmacologic properties for cancer therapy

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29 September 2017

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

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PubMed Central

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29 September 2017

Hsp60 expression, new locations, functions and perspectives for cancer diagnosis and therapy

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PubMed Central

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29 September 2017

SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254259

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29 September 2017

Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network.

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PubMed Central

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29 September 2017

The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions.

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PubMed Central

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29 September 2017

Additive viability-loss following hsp70/hsc70 double interference and Hsp90 inhibition in two breast cancer cell lines

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PubMed Central

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29 September 2017

All in the family: atypical Hsp70 chaperones are conserved modulators of Hsp70 activity.

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254259

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29 September 2017

Targeted therapies for cancer 2004.

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29 September 2017

Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254259

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29 September 2017

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

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PubMed Central

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29 September 2017

Auditing the pharmacological accounts for Hsp90 molecular chaperone inhibitors: unfolding the relationship between pharmacokinetics and pharmacodynamics.

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PubMed Central

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29 September 2017

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

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PubMed Central

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29 September 2017

Hsp70 cochaperones HspBP1 and BAG-1M differentially regulate steroid hormone receptor function.

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254259

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2 June 2018

The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex

1 reference

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PubMed Central

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2 June 2018

Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells

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PubMed Central

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2 June 2018

Cdc37 (cell division cycle 37) restricts Hsp90 (heat shock protein 90) motility by interaction with N-terminal and middle domain binding sites

1 reference

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PubMed Central

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2 June 2018

Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254259

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2 June 2018

Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones

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2 June 2018

Regulatory chaperone complexes in neurodegenerative diseases: a perspective on therapeutic intervention

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PubMed Central

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27 November 2018

A rat retinal damage model predicts for potential clinical visual disturbances induced by Hsp90 inhibitors

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4254259

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27 November 2018

Alterations of the Hsp70/Hsp90 chaperone and the HOP/CHIP co-chaperone system in cancer.

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27 November 2018

BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.

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27 November 2018

A small molecule inhibitor selective for a variant ATP-binding site of the chaperonin GroEL.

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27 November 2018

Drug-target identification from total cellular lysate by drug-induced conformational changes

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27 November 2018

Debio 0932, a new oral Hsp90 inhibitor, alleviates psoriasis in a xenograft transplantation model

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https://pubmed.ncbi.nlm.nih.gov/25262919

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12 December 2020

based on heuristic

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Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes

1 reference

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https://pubmed.ncbi.nlm.nih.gov/25262919

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12 December 2020

based on heuristic

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Associations of HSP90 client proteins in human breast cancer

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25262919

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.TIPS.2014.09.001

0 references

PMC publication ID

4254259

0 references

PubMed publication ID

25262919

0 references

 

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