Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase (Q31108274)

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English	Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

Gabriela Chiosis

1

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Gabriela Chiosis

0 references

Alexander A. Shtil

object named as

Alexander Shtil

3

1 reference

ORCID Public Data File 2021

author name string

Brian Lucas

2

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

Henri Huezo

4

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Europe PubMed Central

PubMed publication ID

28 June 2017

Neal Rosen

5

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Europe PubMed Central

PubMed publication ID

28 June 2017

language of work or name

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publication date

1 November 2002

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

Bioorganic & Medicinal Chemistry

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Europe PubMed Central

PubMed publication ID

28 June 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

11

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

3555-3564

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

Hsp90 as a capacitor for morphological evolution

1 reference

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The Hsp90 complex--a super-chaperone machine as a novel drug target

1 reference

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Hsp90 & Co. - a holding for folding

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Recent Advances in the Study of hsp90 Structure and Mechanism of Action

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Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

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7 January 2021

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inferred from DOI database lookup

The glucose-regulated protein grp94 is related to heat shock protein hsp90.

1 reference

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The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties

1 reference

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Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

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Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

1 reference

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Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

1 reference

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The hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors

1 reference

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p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

1 reference

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Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity

1 reference

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Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

1 reference

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Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

1 reference

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The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

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A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts

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Stereospecific antitumor activity of radicicol oxime derivatives

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A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

1 reference

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Facile synthesis of a library of 9-alkyl-8-benzyl-9H-purin-6-ylamine derivatives

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Purine 2'-deoxy-2'-fluororibosides as antiinfluenza virus agents

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Antiviral activity of C-alkylated purine nucleosides obtained by cross-coupling with tetraalkyltin reagents

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Simple Method of Calculating Octanol/Water Partition Coefficient

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

1 reference

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LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family

1 reference

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In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473

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10.1016/S0968-0896(02)00253-5

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Europe PubMed Central

PubMed publication ID

28 June 2017

release_rcazfnhzqjdpzif5h676mu2l5u

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https://api.fatcat.wiki/v0/release/rcazfnhzqjdpzif5h676mu2l5u

24 November 2022

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 June 2017

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