Molecular insights into regulation of JAK2 in myeloproliferative neoplasms (Q35661987)

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4 March 2020

review article

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title

Molecular insights into regulation of JAK2 in myeloproliferative neoplasms (English)

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4 March 2020

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4 March 2020

Olli Silvennoinen

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4 March 2020

language of work or name

English

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publication date

30 March 2015

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4 March 2020

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4 March 2020

volume

125

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issue

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4 March 2020

page(s)

3388-3392

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ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation

4 March 2020

cites work

1 reference

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Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F.

12 July 2018

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The molecular regulation of Janus kinase (JAK) activation

12 July 2018

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Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase

12 July 2018

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Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

12 July 2018

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Mechanism of activation of protein kinase JAK2 by the growth hormone receptor

12 July 2018

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Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2

12 July 2018

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Somatic mutations of calreticulin in myeloproliferative neoplasms

12 July 2018

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A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

12 July 2018

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Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases

12 July 2018

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JAK/STAT signaling in hematological malignancies.

12 July 2018

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Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

12 July 2018

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The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling

12 July 2018

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Mouse models of myeloproliferative neoplasms: JAK of all grades

12 July 2018

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The constitutive activation of Jak2-V617F is mediated by a π stacking mechanism involving phenylalanines 595 and 617.

12 July 2018

1 reference

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JAK2 V617F constitutive activation requires JH2 residue F595: a pseudokinase domain target for specific inhibitors

12 July 2018

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Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases

12 July 2018

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MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia

12 July 2018

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Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling

12 July 2018

1 reference

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Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor.

12 July 2018

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JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.

12 July 2018

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A gain-of-function mutation of JAK2 in myeloproliferative disorders

12 July 2018

1 reference

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

12 July 2018

1 reference

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Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

12 July 2018

1 reference

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Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858

Some speculations on the myeloproliferative syndromes.

12 July 2018

1 reference

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Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858

The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction

12 July 2018

1 reference

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A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling

12 July 2018

1 reference

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Regulation of the Jak2 tyrosine kinase by its pseudokinase domain

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858

Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains

12 July 2018

1 reference

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The Jak-Stat pathway in normal and perturbed hematopoiesis

12 July 2018

1 reference

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Jak2 is essential for signaling through a variety of cytokine receptors

12 July 2018

1 reference

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Structural and functional basis for JAK3-deficient severe combined immunodeficiency

12 July 2018

1 reference

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Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop

12 July 2018

1 reference

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Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction

12 July 2018

1 reference

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JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858

An amino acid substitution in the Drosophila hopTum-l Jak kinase causes leukemia-like hematopoietic defects.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858

From Janus kinase 2 to calreticulin: the clinically relevant genomic landscape of myeloproliferative neoplasms

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858

Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858

10.1182/BLOOD-2015-01-621110

25 September 2018

Identifiers

DOI

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4 March 2020

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4 March 2020

PubMed publication ID

25824690

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