Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition (Q27683852)

19 October 2023

Mark Ultsch

Mark

Ultsch

1 reference

19 October 2023

Patrick J Lupardus

Patrick J

Lupardus

1 reference

19 October 2023

Heidi Wallweber

series ordinal

author given names

Heidi

author last names

Wallweber

1 reference

19 October 2023

Pawan Bir Kohli

series ordinal

author given names

Pawan

author last names

Bir Kohli

1 reference

19 October 2023

Adam R Johnson

series ordinal

author given names

Adam R

author last names

Johnson

1 reference

Proceedings of the National Academy of Sciences of the United States of America

19 October 2023

language of work or name

English

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publication date

3 June 2014

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published in

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volume

111

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issue

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page(s)

8025-30

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cites work

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Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors

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SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

20 March 2017

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Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

20 March 2017

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A new regulatory switch in a JAK protein kinase

20 March 2017

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Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6

20 March 2017

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Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

20 March 2017

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Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase

20 March 2017

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Jak2 is essential for signaling through a variety of cytokine receptors

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Analysis of Jak2 catalytic function by peptide microarrays: the role of the JH2 domain and V617F mutation

20 March 2017

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Inborn errors of human JAKs and STATs

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The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling

29 September 2017

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The JAK2 exon 12 mutations: A comprehensive review

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JAK2 V617F constitutive activation requires JH2 residue F595: a pseudokinase domain target for specific inhibitors

29 September 2017

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A JAK2 interdomain linker relays Epo receptor engagement signals to kinase activation

29 September 2017

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JAK mutations in high-risk childhood acute lymphoblastic leukemia

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Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome

29 September 2017

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29 September 2017

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Substitution of pseudokinase domain residue Val-617 by large non-polar amino acids causes activation of JAK2.

29 September 2017

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Emerging roles of pseudokinases

29 September 2017

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Jaks and cytokine receptors--an intimate relationship

29 September 2017

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JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.

29 September 2017

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The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction

29 September 2017

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Regulation of the Jak2 tyrosine kinase by its pseudokinase domain

29 September 2017

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The N-termini of FAK and JAKs contain divergent band 4.1 domains

29 September 2017

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Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses

29 September 2017

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Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog

29 September 2017

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The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor

2 June 2018

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Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome

21 January 2018

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Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia.

21 January 2018

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Expression, purification, and characterization of TYK-2 kinase domain, a member of the Janus kinase family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1401180111

Expression, purification, characterization and crystallization of non- and phosphorylated states of JAK2 and JAK3 kinase domain.

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1073/PNAS.1401180111

1 reference

ADS bibcode

2014PNAS..111.8025L

0 references

1 reference

1 reference

1 reference