Mechanism of activation of protein kinase JAK2 by the growth hormone receptor (Q34420222)

2 August 2017

title

Mechanism of activation of protein kinase JAK2 by the growth hormone receptor (English)

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2 August 2017

Yash Chhabra

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Emma Sierecki

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Daniel Abankwa

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Guillermo A Gomez

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Manolis Doxastakis

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Andrew J Brooks

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Craig J Morton

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Kirill Alexandrov

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Megan L O'Mara

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Alan E Mark

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Michael W Parker

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Yann Gambin

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Wei Dai

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2 August 2017

Rebecca A Pelekanos

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2 August 2017

Olivier Gardon

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2 August 2017

Kathryn A Tunny

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2 August 2017

Kristopher M Blucher

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2 August 2017

Ian A Wilson

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2 August 2017

Michael J Waters

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2 August 2017

language of work or name

English

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publication date

1 May 2014

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2 August 2017

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2 August 2017

volume

344

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2 August 2017

issue

6185

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2 August 2017

page(s)

1249783

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The growth hormone receptor: mechanism of activation and clinical implications

2 August 2017

cites work

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Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis

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Model for growth hormone receptor activation based on subunit rotation within a receptor dimer

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Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor

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Ligand-independent dimerization of the human prolactin receptor isoforms: functional implications

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Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation

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An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation

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Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity

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Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F.

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Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling

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Dimerisation of the glycophorin A transmembrane segment in membranes probed with the ToxR transcription activator.

21 January 2018

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The interface between self-assembling erythropoietin receptor transmembrane segments corresponds to a membrane-spanning leucine zipper

21 January 2018

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Homo‐FRET Imaging as a Tool to Quantify Protein and Lipid Clustering

21 January 2018

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Dynamic imaging of homo-FRET in live cells by fluorescence anisotropy microscopy.

21 January 2018

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Full characterization of GPCR monomer-dimer dynamic equilibrium by single molecule imaging

21 January 2018

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Dimerization of receptor protein-tyrosine phosphatase alpha in living cells

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Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-alpha

21 January 2018

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Receptor-like protein tyrosine phosphatase alpha homodimerizes on the cell surface

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Disulfide linkage of growth hormone (GH) receptors (GHR) reflects GH-induced GHR dimerization. Association of JAK2 with the GHR is enhanced by receptor dimerization

21 January 2018

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Growth hormone (GH)-independent dimerization of GH receptor by a leucine zipper results in constitutive activation

21 January 2018

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Design and implementation of bimolecular fluorescence complementation (BiFC) assays for the visualization of protein interactions in living cells

21 January 2018

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Spatio-temporal kinetics of growth hormone receptor signaling in single cells using FRET microscopy

21 January 2018

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Structural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane Complex

21 January 2018

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An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor.

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New insights into growth hormone action.

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GxxxG motifs, phenylalanine, and cholesterol guide the self-association of transmembrane domains of ErbB2 receptors

21 January 2018

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Influence of flanking residues on tilt and rotation angles of transmembrane peptides in lipid bilayers. A solid-state 2H NMR study.

21 January 2018

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Turning the growth hormone receptor on: evidence that hormone binding induces subunit rotation

21 January 2018

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Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization.

21 January 2018

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The ubiquitin-proteasome pathway regulates the availability of the GH receptor

21 January 2018

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Interferon-induced nuclear signalling by Jak protein tyrosine kinases

21 January 2018

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The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor

21 January 2018

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Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

21 January 2018

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21 January 2018

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Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer

21 January 2018

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21 January 2018

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Signal transduction mediated by growth hormone receptor and its chimeric molecules with the granulocyte colony-stimulating factor receptor

21 January 2018

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The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Systematic molecular dynamics searching in a lipid bilayer: application to the glycophorin A and oncogenic ErbB-2 transmembrane domains.

21 January 2018

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21 January 2018

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A computer perspective of membranes: molecular dynamics studies of lipid bilayer systems

21 January 2018

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Generation of mammalian cells stably expressing multiple genes at predetermined levels.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

A versatile viral system for expression and depletion of proteins in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Circular polymerase extension cloning of complex gene libraries and pathways

21 January 2018

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Plat-E: an efficient and stable system for transient packaging of retroviruses

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Unraveling functional and structural interactions between transmembrane domains IV and XI of NhaA Na+/H+ antiporter of Escherichia coli

21 January 2018

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Quantitative fluorescence resonance energy transfer measurements using fluorescence microscopy

21 January 2018

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An analytic solution to the Förster energy transfer problem in two dimensions

21 January 2018

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Pronounced conformational changes following agonist activation of the M(3) muscarinic acetylcholine receptor

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Increased site 1 affinity improves biopotency of porcine growth hormone. Evidence against diffusion dependent receptor dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Molecular spectroscopy and dynamics of intrinsically fluorescent proteins: coral red (dsRed) and yellow (Citrine).

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

HADDOCK versus HADDOCK: new features and performance of HADDOCK2.0 on the CAPRI targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

HADDOCK: a protein-protein docking approach based on biochemical or biophysical information

21 January 2018

1 reference

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21 January 2018

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Definition and testing of the GROMOS force-field versions 54A7 and 54B7

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Computer simulation of the dynamics of hydrated protein crystals and its comparison with x-ray data

21 January 2018

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VMD: visual molecular dynamics

21 January 2018

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Species-independent translational leaders facilitate cell-free expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Direct single-molecule observation of a protein living in two opposed native structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

Molecular dynamics with coupling to an external bath

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1249783

21 January 2018

Identifiers

DOI

10.1126/SCIENCE.1249783

1 reference

2 August 2017

1 reference