Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor (Q47072716)

5 January 2018

title

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor (English)

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5 January 2018

main subject

Drosophila

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Nicastrin Dmel_CG7012

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GOA release 2020-03-11

Presenilin Dmel_CG18803

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GOA release 2020-03-11

author name string

Yue Hu

series ordinal

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5 January 2018

Yihong Ye

series ordinal

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5 January 2018

Mark E Fortini

series ordinal

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5 January 2018

language of work or name

English

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publication date

1 January 2002

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5 January 2018

number of pages

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inferred from page(s)

published in

Developmental Cell

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5 January 2018

volume

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5 January 2018

issue

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5 January 2018

page(s)

69-78

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5 January 2018

Notch signaling: cell fate control and signal integration in development

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Nicastrin binds to membrane-tethered Notch

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Presenilins and the intramembrane proteolysis of proteins: facts and fiction.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

The expression of neurogenic loci in imaginal epidermal cells of Drosophila melanogaster.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Notch and presenilin: a proteolytic mechanism emerges

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

A common enzyme connects notch signaling and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Hyperaccumulation of FAD-linked presenilin 1 variants in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

The Notch1 receptor is cleaved constitutively by a furin-like convertase

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Effects of PS1 deficiency on membrane protein trafficking in neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Kuzbanian Controls Proteolytic Processing of Notch and Mediates Lateral Inhibition during Drosophila and Vertebrate Neurogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Calcium depletion dissociates and activates heterodimeric notch receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Endoproteolytic Processing and Stabilization of Wild-type and Mutant Presenilin

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Translating cell biology into therapeutic advances in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Intramembrane proteolysis by presenilins

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

The Ins and Outs of Notch Signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Characterization of Drosophila Presenilin and its colocalization with Notch during development

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Proteolysis and developmental signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900105-8

7 January 2021

10.1016/S1534-5807(01)00105-8

Identifiers

DOI

1 reference

5 January 2018

1 reference

5 January 2018