Protein Tyrosine Phosphatase 1B Inhibitors: A Molecular Level Legitimate Approach for the Management of Diabetes Mellitus (Q34135843)

31 July 2017

title

Protein tyrosine phosphatase 1B inhibitors: a molecular level legitimate approach for the management of diabetes mellitus (English)

1 reference

31 July 2017

Protein Tyrosine Phosphatase 1B Inhibitors: A Molecular Level Legitimate Approach for the Management of Diabetes Mellitus (English)

1 reference

6 July 2024

Suresh Thareja

1 reference

31 July 2017

Saurabh Aggarwal

1 reference

31 July 2017

Manoj Kumar

1 reference

31 July 2017

T. R. Bhardwaj

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20814956

6 July 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20814956

6 July 2024

publication date

2 September 2010

1 reference

full work available at URL

31 July 2017

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmed.20219

1 reference

https://onlinelibrary.wiley.com/doi/pdf/10.1002/med.20219

6 July 2024

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Medicinal Research Reviews

6 July 2024

published in

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

459-517

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A new orally active antidiabetic vanadyl complex--bis(alpha-furancarboxylato)oxovanadium(IV).

31 July 2017

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Banting lecture 1988. Role of insulin resistance in human disease

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5,6-Diarylanthranilo-1,3-dinitriles as a new class of antihyperglycemic agents

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Rosiglitazone in the treatment of type 2 diabetes mellitus: a critical review

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The thiazolidinediones rosiglitazone and pioglitazone and the risk of coronary heart disease: a retrospective cohort study using a US health insurance database

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Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo

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Peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes

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Hepatic dysfunction and insulin insensitivity in type 2 diabetes mellitus: a critical target for insulin-sensitizing agents

21 January 2018

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Inhibition of protein tyrosine phosphatase 1B as a potential treatment of diabetes and obesity

21 January 2018

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The transmembrane protein tyrosine phosphatase alpha dephosphorylates the insulin receptor in intact cells

21 January 2018

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Control of vesicle fusion by a tyrosine phosphatase

21 January 2018

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Redox modulation of tyrosine phosphorylation-dependent signal transduction pathways

21 January 2018

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Protein tyrosine phosphatases and their inhibitors

21 January 2018

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Oxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides

21 January 2018

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Signaling--2000 and beyond

21 January 2018

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Targeting the PTPome in human disease

21 January 2018

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Significance of protein tyrosine kinase/protein tyrosine phosphatase balance in the regulation of NF-kappaB signaling in the inflammatory process and aging.

21 January 2018

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Initial sequencing and analysis of the human genome

21 January 2018

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Protein-tyrosine phosphatases: biological function, structural characteristics, and mechanism of catalysis

21 January 2018

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Protein tyrosine phosphatases: prospects for therapeutics

21 January 2018

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PTP1B inhibitors as potential therapeutics in the treatment of type 2 diabetes and obesity

21 January 2018

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Role of protein tyrosine phosphatase-1B in diabetes and obesity

21 January 2018

1 reference

Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B

21 January 2018

1 reference

The ins and outs of leptin receptor activation

21 January 2018

1 reference

Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling

21 January 2018

1 reference

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

21 January 2018

1 reference

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

21 January 2018

1 reference

Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis

21 January 2018

1 reference

Neuronal PTP1B regulates body weight, adiposity and leptin action.

21 January 2018

1 reference

Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle

21 January 2018

1 reference

Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues

21 January 2018

1 reference

Protein tyrosine phosphatase 1B inhibition: opportunities and challenges

21 January 2018

1 reference

Protein tyrosine phosphatase-1B in diabetes

21 January 2018

1 reference

Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress

21 January 2018

1 reference

Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress

21 January 2018

1 reference

Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo

21 January 2018

1 reference

Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance

21 January 2018

1 reference

Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer.

21 January 2018

1 reference

Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis

21 January 2018

1 reference

Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells

21 January 2018

1 reference

Inhibition of the protein tyrosine phosphatase PTP1B: potential therapy for obesity, insulin resistance and type-2 diabetes mellitus

21 January 2018

1 reference

Protein tyrosine phosphatases: their role in insulin action and potential as drug targets.

21 January 2018

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Orally active insulin mimics: where do we stand now?

21 January 2018

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Protein tyrosine phosphatase 1B interacts with the activated insulin receptor

21 January 2018

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Protein tyrosine phosphatase 1B inhibitors for diabetes

21 January 2018

1 reference

PTP1B: from the sidelines to the front lines!

21 January 2018

1 reference

Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography

21 January 2018

1 reference

A molecular dynamics study of WPD-loop flexibility in PTP1B.

21 January 2018

1 reference

Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics

21 January 2018

1 reference

Computational analysis of tyrosine phosphatase inhibitor selectivity for the virulence factors YopH and SptP.

21 January 2018

1 reference

Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys

21 January 2018

1 reference

5-Aryl thiazolidine-2,4-diones as selective PPARgamma agonists

21 January 2018

1 reference

Peroxisome proliferator-activated receptors: nuclear control of metabolism

21 January 2018

1 reference

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

21 January 2018

1 reference

New oral therapies for type 2 diabetes mellitus: The glitazones or insulin sensitizers

21 January 2018

1 reference

Rosiglitazone ameliorates abnormal expression and activity of protein tyrosine phosphatase 1B in the skeletal muscle of fat-fed, streptozotocin-treated diabetic rats

21 January 2018

1 reference

Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.

21 January 2018

1 reference

Structure-based optimization of benzoic acids as inhibitors of protein tyrosine phosphatase 1B and low molecular weight protein tyrosine phosphatase.

21 January 2018

1 reference

Thiazolidinedione derivatives as PTP1B inhibitors with antihyperglycemic and antiobesity effects

21 January 2018

1 reference

Self-organizing molecular field analysis of 2,4-thiazolidinediones: A 3D-QSAR model for the development of human PTP1B inhibitors

21 January 2018

1 reference

5-Arylidene-2-phenylimino-4-thiazolidinones as PTP1B and LMW-PTP inhibitors.

21 January 2018

1 reference

Residues distant from the active site influence protein-tyrosine phosphatase 1B inhibitor binding

21 January 2018

1 reference

Prodrugs of phosphates and phosphonates

21 January 2018

1 reference

Utilization of a peptide lead for the discovery of a novel PTP1B-binding motif

21 January 2018

1 reference

The difluoromethylenesulfonic acid group as a monoanionic phosphate surrogate for obtaining PTP1B inhibitors

21 January 2018

1 reference

Alpha,alpha-difluoro-beta-ketophosphonates as potent inhibitors of protein tyrosine phosphatase 1B.

21 January 2018

1 reference

Discovery and structure-activity relationships of novel sulfonamides as potent PTP1B inhibitors

21 January 2018

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PTP1B inhibitors: synthesis and evaluation of difluoro-methylenephosphonate bioisosteres on a sulfonamide scaffold

21 January 2018

1 reference

Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics

21 January 2018

1 reference

Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines

21 January 2018

1 reference

Identification of a monoacid-Based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B

21 January 2018

1 reference

2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity

21 January 2018

1 reference

3D-QSAR CoMFA and CoMSIA on protein tyrosine phosphatase 1B inhibitors

21 January 2018

1 reference

Classification of inhibitors of protein tyrosine phosphatase 1B using molecular structure based descriptors

21 January 2018

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Mechanistic toxicogenomic analysis of WAY-144122 administration in Sprague-Dawley rats

21 January 2018

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Ertiprotafib improves glycemic control and lowers lipids via multiple mechanisms

21 January 2018

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2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases

21 January 2018

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The Cys(X)5Arg catalytic motif in phosphoester hydrolysis

21 January 2018

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Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.

21 January 2018

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Discovery and Structure−Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B

21 January 2018

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Potent, selective inhibitors of protein tyrosine phosphatase 1B

21 January 2018

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Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors

21 January 2018

1 reference

Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents

21 January 2018

1 reference

Discovery of a novel protein tyrosine phosphatase-1B inhibitor, KR61639: potential development as an antihyperglycemic agent

21 January 2018

1 reference

Formylchromone derivatives as a novel class of protein tyrosine phosphatase 1B inhibitors

21 January 2018

1 reference

Formylchromone derivatives as irreversible and selective inhibitors of human protein tyrosine phosphatase 1B. Kinetic and modeling studies

21 January 2018

1 reference

Synthesis and biological activity of a novel class of pyridazine analogues as non-competitive reversible inhibitors of protein tyrosine phosphatase 1B (PTP1B).

21 January 2018

1 reference

Mechanism of action of pyridazine analogues on protein tyrosine phosphatase 1B (PTP1B).

21 January 2018

1 reference

alpha-bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure-Activity relationship

21 January 2018

1 reference

Synthesis of functionalized acetophenones as protein tyrosine phosphatase 1B inhibitors

21 January 2018

1 reference

Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity

21 January 2018

1 reference

PTP-1B inhibitors: cyclopenta[d][1,2]-oxazine derivatives

21 January 2018

1 reference

Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor

21 January 2018

1 reference

Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors

21 January 2018

1 reference

Synthesis of triazole-linked beta-C-glycosyl dimers as inhibitors of PTP1B.

21 January 2018

1 reference

Synthesis of protein tyrosine phosphatase 1B inhibitors: model validation and docking studies

21 January 2018

1 reference

The evolving role of natural products in drug discovery

21 January 2018

1 reference

Natural PTP1B inhibitors from Broussonetia papyrifera

21 January 2018

1 reference

Effects of berberine on glucose metabolism in vitro

21 January 2018

1 reference

Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizoma

21 January 2018

1 reference

Berberine stimulates glucose transport through a mechanism distinct from insulin.

21 January 2018

1 reference

Docking simulations and in vitro assay unveil potent inhibitory action of papaverine against protein tyrosine phosphatase 1B.

21 January 2018

1 reference

Isoprenylated flavonoids from the stem bark of Erythrina abyssinica

21 January 2018

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Flavanones from the stem bark of Erythrina abyssinica

21 January 2018

1 reference

Cinnamic acid, from the bark of Cinnamomum cassia, regulates glucose transport via activation of GLUT4 on L6 myotubes in a phosphatidylinositol 3‐kinase‐independent manner

21 January 2018

1 reference

Peptidyl aldehydes as reversible covalent inhibitors of protein tyrosine phosphatases

21 January 2018

1 reference

Protein tyrosine phosphatase 1B inhibitors from Morus root bark

21 January 2018

1 reference

PTP1B inhibitors from Ardisia japonica

21 January 2018

1 reference

Antidiabetic effects of extracts from Psidium guajava

21 January 2018

1 reference

Molecular design and biological activities of protein-tyrosine phosphatase inhibitors

21 January 2018

1 reference

Hyrtiosal, a PTP1B inhibitor from the marine sponge Hyrtios erectus, shows extensive cellular effects on PI3K/AKT activation, glucose transport, and TGFbeta/Smad2 signaling

21 January 2018

1 reference

Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. I. Taxonomy,isolation, and characterization.

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.46.1342

Antihyperglycemic effect of a new thiazolidinedione analogue and its role in ameliorating oxidative stress in alloxan-induced diabetic rats

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Development and consequences of insulin resistance: lessons from animals with hyperinsulinaemia

6 July 2024

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Banting lecture 1988. Role of insulin resistance in human disease

6 July 2024

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6 July 2024

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6 July 2024

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Sulphonylureas do not increase insulin secretion by a mechanism other than a rise in cytoplasmic Ca2+ in pancreatic B-cells

6 July 2024

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6 July 2024

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Comparison of the effects of acarbose and voglibose in healthy subjects

6 July 2024

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Signal Transduction: An Exciting Field of Investigation for Small Molecule Drug Discovery

6 July 2024

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Structural basis of interaction between protein tyrosine phosphatase PCP-2 and beta-catenin

6 July 2024

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Emerging new techniques for studying protein phosphatases

6 July 2024

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Metabolic perturbations in the pathogenesis of hypertrophic cardiomyopathy

6 July 2024

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Protein tyrosine phosphatase 1B interacts with the activated insulin receptor

6 July 2024

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Protein-tyrosine phosphatases: emerging targets for therapeutic intervention in type 2 diabetes and related states of insulin resistance

6 July 2024

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5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases

6 July 2024

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Structure-based design and synthesis of small molecule protein-tyrosine phosphatase 1B inhibitors

6 July 2024

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Potent Inhibition of Insulin Receptor Dephosphorylation by a Hexamer Peptide Containing the Phosphotyrosyl Mimetic F2Pmp

6 July 2024

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Isothiazolidinone heterocycles as inhibitors of protein tyrosine phosphatases: synthesis and structure-activity relationships of a peptide scaffold

6 July 2024

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Benzothiazole benzimidazole (S)-isothiazolidinone derivatives as protein tyrosine phosphatase-1B inhibitors

6 July 2024

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L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides

6 July 2024

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4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides

6 July 2024

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Examination of novel non-phosphorus-containing phosphotyrosyl mimetics against protein-tyrosine phosphatase-1B and demonstration of differential affinities toward Grb2 SH2 domains

6 July 2024

125

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Methylenedisalicylic acid derivatives: new PTP1B inhibitors that confer resistance to diet-induced obesity

6 July 2024

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Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs

6 July 2024

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Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties

6 July 2024

130

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PTP1B inhibitor Ertiprotafib is also a potent inhibitor of IkappaB kinase beta (IKK-beta)

6 July 2024

135

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The role of vanadium in the management of diabetes

6 July 2024

136

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Pervanadate [peroxide(s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase

6 July 2024

137

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Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate

6 July 2024

139

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Human protein tyrosine phosphatase 1B inhibitors: QSAR by genetic function approximation

6 July 2024

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Berberine potently inhibits protein tyrosine phosphatase 1B: investigation by docking simulation and experimental validation

6 July 2024

169

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Antimicrobial pterocarpans of nigerian Erythrina mildbraedii

6 July 2024

171

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Inhibitory effect of 2-arylbenzofurans from Erythrina addisoniae on protein tyrosine phosphatase-1B

6 July 2024

173

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PTP1B inhibitory activity of kaurane diterpenes isolated fromSiegesbeckia glabrescens

6 July 2024

180

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Inhibition of protein tyrosine phosphatase 1B by diterpenoids isolated from Acanthopanax koreanum

6 July 2024

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Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana

6 July 2024

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PTP1B inhibitors from Saussrurea lappa

6 July 2024

184

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6 July 2024

Identifiers

DOI

10.1002/MED.20219

1 reference

31 July 2017

1 reference