Orally active insulin mimics: where do we stand now? (Q34377857)

1 August 2017

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title

Orally active insulin mimics: where do we stand now? (English)

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1 August 2017

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Balasubramanyam M

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1 August 2017

Mohan V

series ordinal

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1 August 2017

publication date

1 September 2001

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1 August 2017

published in

Journal of Biosciences

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

383-390

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Insulin-mimetic signalling of synthetic phosphoinositolglycans in isolated rat adipocytes

1 August 2017

cites work

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Crossref

https://api.crossref.org/works/10.1007%2FBF02703748

Signalling pathways of an insulin-mimetic phosphoinositolglycan-peptide in muscle and adipose tissue

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF02703748

Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF02703748

Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality

21 January 2018

1 reference

12 December 2020

Lilly Lecture: molecular mechanisms of insulin resistance. Lessons from patients with mutations in the insulin-receptor gene

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12 December 2020

Intracellular localization of phosphatidylinositide 3-kinase and insulin receptor substrate-1 in adipocytes: potential involvement of a membrane skeleton

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12 December 2020

Insulin-sensitive tyrosine kinase: relationship with in vivo insulin action in humans

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12 December 2020

Time-action profile of the long-acting insulin analog insulin glargine (HOE901) in comparison with those of NPH insulin and placebo

1 reference

12 December 2020

Activation of insulin signal transduction pathway and anti-diabetic activity of small molecule insulin receptor activators

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12 December 2020

Extrapancreatic effects of sulfonylureas--a comparison between glimepiride and conventional sulfonylureas.

1 reference

12 December 2020

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects

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12 December 2020

Design and in vivo evaluation of an oral delivery system for insulin

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12 December 2020

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1 reference

12 December 2020

A membrane-anchored cytoplasmic domain of the human insulin receptor mediates a constitutively elevated insulin-independent uptake of 2-deoxyglucose.

1 reference

12 December 2020

Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity

1 reference

12 December 2020

Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes

1 reference

12 December 2020

Traditional plant medicines as treatments for diabetes

1 reference

12 December 2020

Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus

1 reference

12 December 2020

Oral hypoglycaemic activity of Ipomoea aquatica

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12 December 2020

Decreased insulin binding to adipocytes and circulating monocytes from obese subjects

1 reference

12 December 2020

Peroxovanadium compounds: biological actions and mechanism of insulin-mimesis.

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12 December 2020

Insulin action impaired by deficiency of the G-protein subunit G ialpha2

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12 December 2020

Phosphorylation activates the insulin receptor tyrosine protein kinase

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12 December 2020

Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance

1 reference

12 December 2020

Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics

1 reference

12 December 2020

An orally active antidiabetic vanadyl complex, bis(1-oxy-2-pyridinethiolato)oxovanadium(IV), with VO(S2O2) coordination mode; in vitro and in vivo evaluations in rats

1 reference

12 December 2020

Quaternary structure of the insulin-insulin receptor complex

1 reference

12 December 2020

Oral peptide drug delivery: polymer-inhibitor conjugates protecting insulin from enzymatic degradation in vitro

1 reference

12 December 2020

Oral administration of vanadate normalizes blood glucose levels in streptozotocin-treated rats. Characterization and mode of action

1 reference

12 December 2020

Membrane-permeant esters of phosphatidylinositol 3,4,5-trisphosphate

1 reference

12 December 2020

Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B

1 reference

12 December 2020

Insulin-releasing and insulin-like activity of Agaricus campestris (mushroom)

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12 December 2020

Transdermally delivered peroxovanadium can lower blood glucose levels in diabetic rats

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12 December 2020

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

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12 December 2020

A phosphotyrosyl mimetic peptide reverses impairment of insulin-stimulated translocation of GLUT4 caused by overexpression of PTP1B in rat adipose cells

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12 December 2020

Insulin receptor kinase defects as a possible cause of cellular insulin resistance

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12 December 2020

The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake

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12 December 2020

Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects

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12 December 2020

Discovery of a Small Molecule Insulin Mimetic with Antidiabetic Activity in Mice

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12 December 2020

Oral vanadate decreases muscle insulin resistance in obese fa/fa rats.

1 reference

12 December 2020

The molecular mechanism of the insulin-mimetic/sensitizing activity of the antidiabetic sulfonylurea drug Amaryl

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12 December 2020

Peroxovanadate induces tyrosine phosphorylation of phosphoinositide-dependent protein kinase-1

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12 December 2020

Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis

1 reference

12 December 2020

Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.

1 reference

12 December 2020

The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action

1 reference

12 December 2020

The IRS-signalling system: a network of docking proteins that mediate insulin action

1 reference

12 December 2020

Lilly Lecture: syndromes of insulin resistance. From patient to gene and back again

1 reference

12 December 2020

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

1 reference

12 December 2020

2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases

1 reference

12 December 2020

Protein-tyrosine phosphatases PTP1B and syp are modulators of insulin-stimulated translocation of GLUT4 in transfected rat adipose cells

1 reference

12 December 2020

Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects

1 reference

12 December 2020

Regulation of PTP-1 and insulin receptor kinase by fractions from cinnamon: implications for cinnamon regulation of insulin signalling.

1 reference

12 December 2020

New azolidinediones as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties

1 reference

12 December 2020

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

1 reference

12 December 2020

Chemistry and insulin-like properties of vanadium(IV) and vanadium(V) compounds

1 reference

12 December 2020

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1 reference

12 December 2020

Mechanism of activation and function of protein kinase B.

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12 December 2020

Discovery of a potent, highly selective, and orally efficacious small-molecule activator of the insulin receptor

1 reference

12 December 2020

Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity

1 reference

12 December 2020

Vanadyl-biguanide complexes as potential synergistic insulin mimics

1 reference

12 December 2020

Growth factor-induced stimulation of hexose transport in 3T3-L1 adipocytes: evidence that insulin-induced translocation of GLUT4 is independent of activation of MAP kinase.

1 reference

12 December 2020

Early Signaling Events Triggered by Peroxovanadium [bpV(phen)] Are Insulin Receptor Kinase (IRK)-Dependent: Specificity of Inhibition of IRK-Associated Protein Tyrosine Phosphatase(s) by bpV(phen)

1 reference

12 December 2020

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse

1 reference

12 December 2020

Oral insulin delivery

1 reference

12 December 2020

Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats

1 reference

12 December 2020

Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism

1 reference

12 December 2020

Mechanisms of vanadium action: insulin-mimetic or insulin-enhancing agent?

1 reference

12 December 2020

Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor

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12 December 2020

Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B

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12 December 2020

Identifiers

DOI

10.1007/BF02703748

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Dimensions Publication ID

1 August 2017

1014523341

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