Tyrosine kinase non receptor 2 (Q21115284)

Cdc42 binding domain-like superfamily

1 reference

Protein kinase-like domain superfamily

1 reference

Activated CDC42 kinase 1

1 reference

Mig-6 domain, protein family

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Cdc42 binding domain-like, protein family

1 reference

SH3 domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

1 reference

5 December 2018

1 reference

5 December 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

1 reference

8 April 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

1 reference

8 April 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

1 reference

8 April 2019

epidermal growth factor receptor binding

1 reference

8 April 2019

HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

GTPase inhibitor activity

1 reference

8 April 2019

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

1 reference

8 April 2019

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

1 reference

8 April 2019

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

1 reference

8 April 2019

protein binding

9 references

8 April 2019

Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

8 April 2019

Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

8 April 2019

Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

8 April 2019

Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

8 April 2019

Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

8 April 2019

Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

8 April 2019

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

WW domain binding

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

protein tyrosine kinase activity

ISS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

8 April 2019

8 April 2019

Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

ubiquitin protein ligase binding

1 reference

8 April 2019

Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

non-membrane spanning protein tyrosine kinase activity

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

extrinsic component of cytoplasmic side of plasma membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07912&geneProductId=UniProtKB:Q07912

1 reference

31 October 2017

adherens junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

1 reference

8 April 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

3 references

8 April 2019

8 April 2019

Regulation of Ack1 localization and activity by the amino-terminal SAM domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

8 April 2019

Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

1 reference

8 April 2019

Grb2-EGFR complex

1 reference

8 April 2019

HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

cytoplasmic vesicle membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

1 reference

8 April 2019

cytoplasmic vesicle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

1 reference

8 April 2019

perinuclear region of cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

1 reference

8 April 2019

cytoophidium

1 reference

8 April 2019

Ack kinase regulates CTP synthase filaments during Drosophila oogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

biological process

cell differentiation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

1 reference

8 April 2019

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

8 April 2019

8 April 2019

Regulation of Ack1 localization and activity by the amino-terminal SAM domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

8 April 2019

Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

transmembrane receptor protein tyrosine kinase signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07912&geneProductId=UniProtKB:Q07912

1 reference

31 October 2017

small GTPase mediated signal transduction

1 reference

8 April 2019

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

1 reference

8 April 2019

cell surface receptor signaling pathway

1 reference

8 April 2019

Shepherding AKT and androgen receptor by Ack1 tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

regulation of cell population proliferation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

peptidyl-tyrosine autophosphorylation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

regulation of clathrin-dependent endocytosis

1 reference

8 April 2019

Dysregulation of Ack1 inhibits down-regulation of the EGF receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07912&geneProductId=UniProtKB:Q07912

1 reference

31 October 2017

cell migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07912&geneProductId=UniProtKB:Q07912

1 reference

31 October 2017

negative regulation of GTPase activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

1 reference

8 April 2019

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

5710

English

tyrosine-protein kinase, active site

17 August 2016

has part(s)

1 reference

Cdc42 binding domain-like

1 reference

SH3 domain

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

Mig-6 domain

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

Identifiers

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

5 December 2018

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016