Shepherding AKT and androgen receptor by Ack1 tyrosine kinase (Q24308859)

cell surface receptor signaling pathway

GOA release 2020-03-11

1 reference

Journal of Cellular Physiology

GOA release 2020-03-11

author name string

Kiran Mahajan

series ordinal

0 references

Nupam P Mahajan

series ordinal

0 references

language of work or name

English

0 references

publication date

August 2010

0 references

published in

0 references

volume

224

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issue

0 references

page(s)

327-33

0 references

cites work

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Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas

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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

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Three-dimensional structure of the tyrosine kinase c-Src

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Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation

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Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox

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SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1

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Crystal structures of the phosphorylated and unphosphorylated kinase domains of the Cdc42-associated tyrosine kinase ACK1

19 March 2017

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The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma

19 March 2017

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Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck

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19 March 2017

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19 March 2017

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The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors

19 March 2017

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19 March 2017

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19 March 2017

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Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer

19 March 2017

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Exploiting the PI3K/AKT pathway for cancer drug discovery

7 April 2017

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FOXO transcription factors at the interface between longevity and tumor suppression

7 April 2017

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7 April 2017

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

7 April 2017

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7 April 2017

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Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

7 April 2017

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Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity.

10 May 2017

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Effects of EGFR tyrosine kinase inhibitor erlotinib in prostate cancer cells in vitro.

27 September 2017

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An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer

27 September 2017

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Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks

27 September 2017

1 reference

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Nephrocystin-1 interacts directly with Ack1 and is expressed in human collecting duct

27 September 2017

1 reference

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Results from a monocentric phase II trial of erlotinib in patients with metastatic prostate cancer

27 September 2017

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TNK2 preserves epidermal growth factor receptor expression on the cell surface and enhances migration and invasion of human breast cancer cells

27 September 2017

1 reference

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A phase II trial of docetaxel and erlotinib as first-line therapy for elderly patients with androgen-independent prostate cancer

27 September 2017

1 reference

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Dynamic FoxO transcription factors

27 September 2017

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PTEN, more than the AKT pathway

27 September 2017

1 reference

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The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation

27 September 2017

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Activated AKT/PKB signaling in C. elegans uncouples temporally distinct outputs of DAF-2/insulin-like signaling

27 September 2017

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Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953130

The Akt/PKB pathway: molecular target for cancer drug discovery

27 September 2017

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Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953130

PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle

27 September 2017

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The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: Modifications to the androgen receptor.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953130

Frequent loss of WWOX expression in breast cancer: correlation with estrogen receptor status

27 September 2017

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Incidence, mechanism and prognostic value of activated AKT in pancreas cancer

27 September 2017

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Androgen receptor signaling in androgen-refractory prostate cancer

27 September 2017

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AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953130

HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953130

An intramolecular SH3-domain interaction regulates c-Abl activity

27 September 2017

1 reference

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Vertebrate non-receptor protein-tyrosine kinase families

27 September 2017

1 reference

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Allelic loss of chromosomes 16q and 10q in human prostate cancer

27 September 2017

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Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor

27 September 2017

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Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling

27 September 2017

1 reference

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Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.

30 May 2018

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PI3K/AKT pathway activation in acute myeloid leukaemias is not associated with AKT1 pleckstrin homology domain mutation

30 May 2018

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A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase.

30 May 2018

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A phase II trial of gefitinib in patients with non-metastatic hormone-refractory prostate cancer

30 May 2018

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Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and preliminary SAR.

29 November 2018

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Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

29 November 2018

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Randomized phase II study of two doses of gefitinib in hormone-refractory prostate cancer: a trial of the National Cancer Institute of Canada-Clinical Trials Group

29 November 2018

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An SH2 domain-dependent, phosphotyrosine-independent interaction between Vav1 and the Mer receptor tyrosine kinase: a mechanism for localizing guanine nucleotide-exchange factor action

29 November 2018

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Tyrosine kinases as targets for cancer therapy

29 November 2018

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