HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK (Q24296458)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20086093%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20086093%20AND%20SRC:MED&resulttype=core&format=json

NEDD4 E3 ubiquitin protein ligase

16 January 2020

main subject

cell biology

0 references

1 reference

Tyrosine kinase non receptor 2

1 reference

Growth factor receptor bound protein 2

1 reference

Tyrosine kinase, non-receptor, 2

1 reference

protein ubiquitination

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20086093%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Jian Wang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20086093%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Chandra Childress

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20086093%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Marius Sudol

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20086093%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

David J Carey

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20086093%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Wannian Yang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20086093%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

language of work or name

English

0 references

publication date

19 January 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20086093%20AND%20SRC:MED&resulttype=core&format=json

Molecular and Cellular Biology

16 January 2020

published in

1 reference

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16 January 2020

volume

1 reference

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16 January 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20086093%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

page(s)

1541-1554

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20086093%20AND%20SRC:MED&resulttype=core&format=json

SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling

16 January 2020

cites work

1 reference

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Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface

19 March 2017

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Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation

19 March 2017

1 reference

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Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination

19 March 2017

1 reference

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The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation

19 March 2017

1 reference

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Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas

19 March 2017

1 reference

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WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome

19 March 2017

1 reference

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Oligomeric structure of the human EphB2 receptor SAM domain

19 March 2017

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

19 March 2017

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Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain

7 April 2017

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Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation

19 March 2017

1 reference

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Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox

19 March 2017

1 reference

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Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function

19 March 2017

1 reference

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Mig-6 is a negative regulator of the epidermal growth factor receptor signal

19 March 2017

1 reference

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The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors

19 March 2017

1 reference

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Stimulation of M3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated kinase-1 via a Fyn tyrosine kinase signaling pathway

19 March 2017

1 reference

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Tyrosine phosphorylation of ACK in response to temperature shift-down, hyperosmotic shock, and epidermal growth factor stimulation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832494

Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832494

Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

19 March 2017

1 reference

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Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

7 April 2017

1 reference

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c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

7 April 2017

1 reference

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Ubiquitination of gap junction proteins

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832494

Nedd4-2 catalyzes ubiquitination and degradation of cell surface ENaC.

27 September 2017

1 reference

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p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832494

Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132.

27 September 2017

1 reference

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Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli

27 September 2017

1 reference

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Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1

27 September 2017

1 reference

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Interaction of activated Cdc42-associated tyrosine kinase ACK2 with HSP90.

27 September 2017

1 reference

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Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases

27 September 2017

1 reference

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The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture

27 September 2017

1 reference

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Relative contribution of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by RNA interference

27 September 2017

1 reference

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WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation

27 September 2017

1 reference

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Ligand-independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and Hgs, an adaptor whose ubiquitin-interacting motif targets ubiquitylation by Nedd4.

27 September 2017

1 reference

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ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster

27 September 2017

1 reference

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NEDD4L on human chromosome 18q21 has multiple forms of transcripts and is a homologue of the mouse Nedd4-2 gene.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832494

The Cdc42 target ACK2 directly interacts with clathrin and influences clathrin assembly

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832494

NeW wrinkles for an old domain

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832494

Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832494

Activation of the Cdc42-associated tyrosine kinase-2 (ACK-2) by cell adhesion via integrin beta1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832494

Fibronectin matrix regulates activation of RHO and CDC42 GTPases and cell cycle progression

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832494

Cloning and Characterization of a Novel Cdc42-associated Tyrosine Kinase, ACK-2, from Bovine Brain

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832494

Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832494

Molecular mechanisms of coupled monoubiquitination

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832494

Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832494

ARK-1 inhibits EGFR signaling in C. elegans

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832494

Inhibition of the epithelial Na+ channel by interaction of Nedd4 with a PY motif deleted in Liddle's syndrome

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832494

Negative regulation of epidermal growth factor signaling by selective proteolytic mechanisms in the endosome mediated by cathepsin B

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20086093

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20086093

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

RNA interference screen reveals an essential role of Nedd4-2 in dopamine transporter ubiquitination and endocytosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20086093

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.00013-10

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20086093%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20086093%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

20086093

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20086093%20AND%20SRC:MED&resulttype=core&format=json