Tyrosine kinase non receptor 2 (Q21115284)

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mammalian protein found in Homo sapiens

activated p21cdc42Hs kinase
TNK2
tyrosine kinase non-receptor protein 2
activated CDC42 kinase 1
activated Cdc42-associated kinase 1

Language	Label	Description	Also known as
English	Tyrosine kinase non receptor 2	mammalian protein found in Homo sapiens	activated p21cdc42Hs kinase TNK2 tyrosine kinase non-receptor protein 2 activated CDC42 kinase 1 activated Cdc42-associated kinase 1

Statements

1 reference

5 December 2018

UniProt protein ID

SH3-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q07912

Cdc42 binding domain-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q07912

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q07912

Activated CDC42 kinase 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q07912

Mig-6 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cdc42 binding domain-like, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

5 December 2018

UniProt protein ID

1 reference

5 December 2018

UniProt protein ID

molecular function

transferase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

nucleotide binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

protein kinase activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

epidermal growth factor receptor binding

determination method or standard

1 reference

8 April 2019

HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

GTPase inhibitor activity

determination method or standard

1 reference

8 April 2019

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

kinase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

protein serine/threonine kinase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

protein binding

determination method or standard

9 references

8 April 2019

Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

8 April 2019

Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

8 April 2019

Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

8 April 2019

Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

8 April 2019

Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

8 April 2019

Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

8 April 2019

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

WW domain binding

determination method or standard

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

protein tyrosine kinase activity

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

8 April 2019

Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

ubiquitin protein ligase binding

determination method or standard

1 reference

8 April 2019

Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

non-membrane spanning protein tyrosine kinase activity

determination method or standard

3 references

8 April 2019

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

extrinsic component of cytoplasmic side of plasma membrane

determination method or standard

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07912&geneProductId=UniProtKB:Q07912

determination method or standard

adherens junction

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

plasma membrane

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

8 April 2019

Regulation of Ack1 localization and activity by the amino-terminal SAM domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

8 April 2019

Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

Grb2-EGFR complex

determination method or standard

1 reference

8 April 2019

HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

cytoplasmic vesicle membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

cytoplasmic vesicle

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

perinuclear region of cytoplasm

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

determination method or standard

1 reference

8 April 2019

Ack kinase regulates CTP synthase filaments during Drosophila oogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

biological process

cell differentiation

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

phosphorylation

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

8 April 2019

Regulation of Ack1 localization and activity by the amino-terminal SAM domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

8 April 2019

Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

transmembrane receptor protein tyrosine kinase signaling pathway

determination method or standard

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07912&geneProductId=UniProtKB:Q07912

determination method or standard

small GTPase mediated signal transduction

determination method or standard

1 reference

8 April 2019

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

protein phosphorylation

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

cell surface receptor signaling pathway

determination method or standard

1 reference

8 April 2019

Shepherding AKT and androgen receptor by Ack1 tyrosine kinase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

regulation of cell population proliferation

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

positive regulation of peptidyl-tyrosine phosphorylation

determination method or standard

1 reference

8 April 2019

Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

peptidyl-tyrosine autophosphorylation

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

regulation of clathrin-dependent endocytosis

determination method or standard

1 reference

8 April 2019

Dysregulation of Ack1 inhibits down-regulation of the EGF receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

innate immune response

determination method or standard

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07912&geneProductId=UniProtKB:Q07912

determination method or standard

determination method or standard

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07912&geneProductId=UniProtKB:Q07912

determination method or standard

negative regulation of GTPase activity

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

signal transduction

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912

determination method or standard

physically interacts with

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

tyrosine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q07912

Cdc42 binding domain-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q07912

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q07912

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q07912

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q07912

tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q07912

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q07912

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q07912

Identifiers

RefSeq protein ID

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

UniProt protein ID

1 reference

5 December 2018

UniProt protein ID

Ensembl protein ID

ENSP00000329425

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000329425

ENSP00000371341

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000371341

ENSP00000395588

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000395588

ENSP00000392546

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000392546

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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