Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor (Q41067751)

26 September 2017

title

Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor (English)

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26 September 2017

Moscatello DK

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26 September 2017

Holgado-Madruga M

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26 September 2017

Emlet DR

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26 September 2017

Montgomery RB

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26 September 2017

Wong AJ

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26 September 2017

language of work or name

English

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publication date

1 January 1998

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Journal of Biological Chemistry

26 September 2017

published in

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26 September 2017

volume

273

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26 September 2017

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26 September 2017

page(s)

200-206

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Structural alterations of the epidermal growth factor receptor gene in human gliomas

26 September 2017

cites work

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Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors

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EGFR gene amplification--rearrangement in human glioblastomas

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A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity

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Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma

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The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

21 January 2018

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Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-Shc-Grb2 pathway

21 January 2018

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Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

21 January 2018

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Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor

21 January 2018

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Phosphatidylinositol 3-kinase

21 January 2018

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21 January 2018

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Phosphorylation of middle T by pp60c-src: a switch for binding of phosphatidylinositol 3-kinase and optimal tumorigenesis

21 January 2018

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Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

21 January 2018

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The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors

21 January 2018

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A Grb2-associated docking protein in EGF- and insulin-receptor signalling

21 January 2018

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Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors

21 January 2018

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Tyrosine kinase inhibition: an approach to drug development

21 January 2018

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Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

21 January 2018

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Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alpha

21 January 2018

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Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain

21 January 2018

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Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex

21 January 2018

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Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway

21 January 2018

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Requirement for phosphatidylinositol 3-kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells

21 January 2018

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Rho Family GTPases Bind to Phosphoinositide Kinases

21 January 2018

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Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

21 January 2018

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Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.273.1.200

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26 September 2017

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