Synuclein alpha (Q288591)

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mammalian protein found in Homo sapiens
  • synuclein, alpha (non A4 component of amyloid precursor)
  • synuclein alpha-140
  • truncated alpha synuclein
  • Non-A4 component of amyloid precursor
  • SNCA
  • Non-A beta component of AD amyloid
  • non A-beta component of AD amyloid
  • alpha-synuclein
  • I+/--synuclein
  • NACP
edit
Language Label Description Also known as
English
Synuclein alpha
mammalian protein found in Homo sapiens
  • synuclein, alpha (non A4 component of amyloid precursor)
  • synuclein alpha-140
  • truncated alpha synuclein
  • Non-A4 component of amyloid precursor
  • SNCA
  • Non-A beta component of AD amyloid
  • non A-beta component of AD amyloid
  • alpha-synuclein
  • I+/--synuclein
  • NACP

Statements

molecular function
protein binding
determination method or standard
IPI
22 references
retrieved
8 April 2019
stated in
Modulation of the trafficking of the human serotonin transporter by human alpha-synuclein
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Redox activity of α-synuclein–Cu is silenced by Zn7-metallothionein-3
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Attenuation of the norepinephrine transporter activity and trafficking via interactions with alpha-synuclein
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Functional dissection of the alpha-synuclein promoter: transcriptional regulation by ZSCAN21 and ZNF219
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease.
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Redistribution of DAT/α-synuclein complexes visualized by "in situ" proximity ligation assay in transgenic mice modelling early Parkinson's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
α-Synuclein modifies huntingtin aggregation in living cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Analysis of synphilin-1 and synuclein interactions by yeast two-hybrid beta-galactosidase liquid assay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human α-synuclein modulates vesicle trafficking through its interaction with prenylated Rab acceptor protein 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
A role for alpha-synuclein in the regulation of dopamine biosynthesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulated interactions of the norepineprhine transporter by the actin and microtubule cytoskeletons
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
identical protein binding
determination method or standard
IDA
IEA
IPI
17 references
retrieved
8 April 2019
stated in
α-Synuclein modifies huntingtin aggregation in living cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Dequalinium-induced protofibril formation of alpha-synuclein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
α-Synuclein as an intrinsically disordered monomer--fact or artefact?
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Acceleration of alpha-synuclein aggregation by homologous peptides
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
The N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IPI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IEA
retrieved
8 April 2019
stated in
Molecular determinants of α-synuclein mutants' oligomerization and membrane interactions
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IDA
retrieved
8 April 2019
stated in
The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IDA
cell component
cytoplasm
determination method or standard
IDA
IEA
11 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IEA
retrieved
8 April 2019
stated in
Molecular determinants of α-synuclein mutants' oligomerization and membrane interactions
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IDA
retrieved
8 April 2019
stated in
alpha-Synuclein and its disease-related mutants interact differentially with the microtubule protein tau and associate with the actin cytoskeleton
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IDA
retrieved
8 April 2019
stated in
Upregulation of alpha-synuclein by lipopolysaccharide and interleukin-1 in human macrophages
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IDA
retrieved
8 April 2019
stated in
Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IDA
retrieved
8 April 2019
stated in
Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IDA
retrieved
8 April 2019
stated in
Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IDA
retrieved
8 April 2019
stated in
Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IDA
retrieved
8 April 2019
stated in
Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IDA
nucleus
determination method or standard
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IEA
retrieved
8 April 2019
stated in
Upregulation of alpha-synuclein by lipopolysaccharide and interleukin-1 in human macrophages
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IDA
retrieved
8 April 2019
stated in
alpha-Synuclein and its disease-related mutants interact differentially with the microtubule protein tau and associate with the actin cytoskeleton
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IDA
retrieved
8 April 2019
stated in
Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IDA
retrieved
8 April 2019
stated in
The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity
GOA
curator
UniProt
UniProt protein ID
P37840
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37840
determination method or standard
IDA
biological process
Gene Atlas image
PBB GE SNCA 204466 s at fs.png
732 × 530; 11 KB
0 references
Commons category
Alpha-synuclein
0 references

Identifiers

Microsoft Academic ID
2781449126
0 references
2910879917
0 references
PDB structure ID
 
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