The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity (Q24299289)

GOA release 2020-03-11

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8 June 2020

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8 June 2020

Francesco Simone Ruggeri

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8 June 2020

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8 June 2020

Igor Dikiy

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8 June 2020

Anne-Laure Mahul-Mellier

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8 June 2020

Martial K Mbefo

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8 June 2020

Filip Vercruysse

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8 June 2020

Giovanni Dietler

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8 June 2020

David Eliezer

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8 June 2020

Bruno Fauvet

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8 June 2020

Hilal A Lashuel

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8 June 2020

language of work or name

English

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publication date

8 August 2014

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number of pages

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

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8 June 2020

volume

289

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8 June 2020

issue

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8 June 2020

page(s)

21856-21876

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describes a project that uses

8 June 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4139205/fullTextXML

inferred from PubMed Central ID database lookup

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Coordination Features and Affinity of the Cu2+ Site in the α-Synuclein Protein of Parkinson’s Disease

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Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

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The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.

7 April 2017

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In vitro study of α-synuclein protofibrils by cryo-EM suggests a Cu(2+)-dependent aggregation pathway

27 September 2017

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Somatic alpha-synuclein mutations in Parkinson's disease: hypothesis and preliminary data

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α-Synuclein mutations cluster around a putative protein loop

27 September 2017

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Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease.

27 September 2017

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A novel α-synuclein missense mutation in Parkinson disease

27 September 2017

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The many faces of α-synuclein: from structure and toxicity to therapeutic target

27 September 2017

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Extracellular signal-regulated kinase is involved in alpha-synuclein-induced mitochondrial dynamic disorders by regulating dynamin-like protein 1.

27 September 2017

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Phosphorylation of α-synuclein protein at Ser-129 reduces neuronal dysfunction by lowering its membrane binding property in Caenorhabditis elegans

27 September 2017

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Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers.

27 September 2017

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27 September 2017

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Heat‐shock protein 70 modulates toxic extracellular α‐synuclein oligomers and rescues trans‐synaptic toxicity

27 September 2017

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Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies

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Aggregates assembled from overexpression of wild-type alpha-synuclein are not toxic to human neuronal cells

27 September 2017

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27 September 2017

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27 September 2017

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Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

27 September 2017

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The alpha-synuclein mutation E46K promotes aggregation in cultured cells

27 September 2017

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27 September 2017

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Helix periodicity, topology, and dynamics of membrane-associated alpha-synuclein

27 September 2017

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Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

27 September 2017

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Structure and dynamics of micelle-bound human alpha-synuclein

27 September 2017

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A general model for amyloid fibril assembly based on morphological studies using atomic force microscopy

27 September 2017

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Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

27 September 2017

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Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity

27 September 2017

1 reference

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Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

27 September 2017

1 reference

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Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

27 September 2017

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Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells

27 September 2017

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Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125.

27 September 2017

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Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy

27 September 2017

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E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein

30 May 2018

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Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

30 May 2018

1 reference

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Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

21 January 2018

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Conformational properties of alpha-synuclein in its free and lipid-associated states

21 January 2018

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A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins

21 January 2018

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Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease.

21 January 2018

1 reference

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Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein

21 January 2018

1 reference

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Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

21 January 2018

1 reference

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Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.553297

The Parkinson's disease-associated H50Q mutation accelerates α-Synuclein aggregation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.553297

NMR mapping of copper binding sites in alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.553297

Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis

21 January 2018

1 reference

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Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations

21 January 2018

1 reference

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A novel mechanism of interaction between alpha-synuclein and biological membranes

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24936070

12 December 2020

inferred from PubMed ID database lookup

Copper(II) binding by fragments of alpha-synuclein containing M1-D2- and -H50-residues; a combined potentiometric and spectroscopic study

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24936070

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M114.553297

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24936070%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24936070%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

PubMed publication ID

24936070

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24936070%20AND%20SRC:MED&resulttype=core&format=json