Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain (Q24321216)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25732184%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain (English)

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1 March 2020

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GOA release 2020-03-11

identical protein binding

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GOA release 2020-03-11

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25732184%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Rosalind F Roberts

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1 March 2020

Javier Alegre-Abarrategui

series ordinal

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1 March 2020

language of work or name

English

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publication date

1 March 2015

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1 March 2020

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1 March 2020

volume

138

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1 March 2020

issue

Pt 6

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1 March 2020

page(s)

1642-1657

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α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

1 March 2020

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α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

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The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia

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Immunoelectron-microscopic demonstration of NACP/alpha-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

19 March 2017

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Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

7 April 2017

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7 April 2017

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Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

7 April 2017

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Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

7 April 2017

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α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease

7 April 2017

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Prion-like spreading of pathological α-synuclein in brain

27 September 2017

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Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking

27 September 2017

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Direct observation of the interconversion of normal and toxic forms of α-synuclein

27 September 2017

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Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

27 September 2017

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Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.

27 September 2017

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A soluble α-synuclein construct forms a dynamic tetramer

27 September 2017

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Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis

27 September 2017

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The parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons

27 September 2017

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Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer

27 September 2017

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In vivo demonstration that alpha-synuclein oligomers are toxic

27 September 2017

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The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

27 September 2017

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Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?

27 September 2017

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Biochemical characterization of the core structure of alpha-synuclein filaments

27 September 2017

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Spectrum of Parkinson's disease, Parkinson's dementia, and Lewy body dementia.

27 September 2017

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Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

27 September 2017

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Identification of two distinct synucleins from human brain

27 September 2017

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The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

27 September 2017

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Lewy bodies in cerebral cortex, report of three cases

27 September 2017

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27 September 2017

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Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization

27 September 2017

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Relationships between Lewy bodies and pale bodies in Parkinson's disease

30 May 2018

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Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure

30 May 2018

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Oligomeric alpha-synuclein inhibits tubulin polymerization

21 January 2018

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Different species of alpha-synuclein oligomers induce calcium influx and seeding.

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21 January 2018

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Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion

21 January 2018

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Evidence that Loading of Cohesin Onto Chromosomes Involves Opening of Its SMC Hinge

21 January 2018

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Pale neurites, premature α-synuclein aggregates with centripetal extension from axon collaterals

21 January 2018

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A paced visual serial addition test for fMRI.

21 January 2018

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Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies.

21 January 2018

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Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62.

21 January 2018

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Neurodegenerative disease: amyloid pores from pathogenic mutations

21 January 2018

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Characterization of cytoplasmic alpha-synuclein aggregates. Fibril formation is tightly linked to the inclusion-forming process in cells

21 January 2018

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Accumulation of α-synuclein triggered by presynaptic dysfunction

21 January 2018

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Regional distribution of proteinase K-resistant alpha-synuclein correlates with Lewy body disease stage.

21 January 2018

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Evaluation of a novel proximity ligation assay for the sensitive and rapid detection of foot-and-mouth disease virus

21 January 2018

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Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

21 January 2018

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Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease

21 January 2018

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Structural properties of pore-forming oligomers of alpha-synuclein

21 January 2018

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Novel means of viral antigen identification: improved detection of avian influenza viruses by proximity ligation

21 January 2018

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Developmental stages of cortical Lewy bodies and their relation to axonal transport blockage in brains of patients with dementia with Lewy bodies

21 January 2018

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Secondary structure of alpha-synuclein oligomers: characterization by raman and atomic force microscopy

29 November 2018

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12 December 2020

Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease

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12 December 2020

alpha-Synuclein protofibrils inhibit 26 S proteasome-mediated protein degradation: understanding the cytotoxicity of protein protofibrils in neurodegenerative disease pathogenesis.

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12 December 2020

alpha-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining

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12 December 2020

Identifiers

DOI

10.1093/BRAIN/AWV040

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25732184%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25732184%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

PubMed publication ID

25732184

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25732184%20AND%20SRC:MED&resulttype=core&format=json