Allosteric Inhibition of Human Immunodeficiency Virus Integrase (Q27644578)

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Benjamin M Dyer

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Nirav Malani

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Young Hwang

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Frances Male

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Robert T Nolte

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Liping Wang

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Emile Velthuisen

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Jerry Jeffrey

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Gregory D Van Duyne

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Frederic D Bushman

Journal of Biological Chemistry

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language of work or name

English

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publication date

25 July 2014

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published in

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volume

289

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issue

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page(s)

20477-88

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cites work

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The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

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New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action

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Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

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A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

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LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

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A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

20 March 2017

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Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences

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LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes

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LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

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Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain

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Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding

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Features and development of Coot

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Refinement of macromolecular structures by the maximum-likelihood method

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Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

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A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors

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HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

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Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

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Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase

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Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells

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Selection of target sites for mobile DNA integration in the human genome

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HIV-1 integration in the human genome favors active genes and local hotspots

20 March 2017

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Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1.

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Allosteric inhibition of HIV-1 integrase activity

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Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization

29 September 2017

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HIV-1 antiretroviral drug therapy

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Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs

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Transcriptional coactivator LEDGF/p75 modulates human immunodeficiency virus type 1 integrase-mediated concerted integration

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