Development of an AlphaScreen-based HIV-1 integrase dimerization assay for discovery of novel allosteric inhibitors (Q45157847)

10 December 2017

title

Development of an AlphaScreen-based HIV-1 integrase dimerization assay for discovery of novel allosteric inhibitors (English)

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10 December 2017

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10 December 2017

Zeger Debyser

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Frauke Christ

series ordinal

object named as

Frauke Christ

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10 December 2017

Maurizio Botta

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10 December 2017

Cristina Tintori

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10 December 2017

publication date

14 February 2012

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Journal of Biomolecular Screening

10 December 2017

published in

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10 December 2017

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10 December 2017

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10 December 2017

page(s)

618-628

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Integrase and integration: biochemical activities of HIV-1 integrase

10 December 2017

cites work

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Transportin-SR2 imports HIV into the nucleus

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Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity

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Raltegravir: a review of its pharmacokinetics, pharmacology and clinical studies

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Resistance associated mutations to dolutegravir (S/GSK1349572) in HIV-infected patients--impact of HIV subtypes and prior raltegravir experience

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In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer

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Allosteric Inhibitor Development Targeting HIV‐1 Integrase

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Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

21 January 2018

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Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium

21 January 2018

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Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization

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Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

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Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex

21 January 2018

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Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation

21 January 2018

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LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

21 January 2018

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An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule

21 January 2018

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Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry

21 January 2018

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Symmetrical 1-pyrrolidineacetamide showing anti-HIV activity through a new binding site on HIV-1 integrase

21 January 2018

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Luminescent oxygen channeling immunoassay: measurement of particle binding kinetics by chemiluminescence.

21 January 2018

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Rapid microtiter assays for poxvirus topoisomerase, mammalian type IB topoisomerase and HIV-1 integrase: application to inhibitor isolation

21 January 2018

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 January 2018

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A pair of new statistical parameters for quality control in RNA interference high-throughput screening assays

21 January 2018

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New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

21 January 2018

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Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1177/1087057111436343

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10 December 2017

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