Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells (Q28536951)

object named as

Anita Niedziela-Majka

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Roman Sakowicz

object named as

Roman Sakowicz

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author name string

Mini Balakrishnan

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Stephen R Yant

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Luong Tsai

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Christopher O'Sullivan

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Rujuta A Bam

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Angela Tsai

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Kirsten M Stray

Creative Commons Attribution 4.0 International

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language of work or name

English

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publication date

2013

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e74163

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start time

9 September 2013

1 reference

April 2022 Public Data File from Crossref

copyrighted

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cites work

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Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

19 March 2017

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19 March 2017

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19 March 2017

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Raltegravir with optimized background therapy for resistant HIV-1 infection

19 March 2017

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LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

19 March 2017

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19 March 2017

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A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

19 March 2017

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Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

19 March 2017

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Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase

19 March 2017

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Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain

19 March 2017

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The conserved set of host proteins incorporated into HIV-1 virions suggests a common egress pathway in multiple cell types

19 March 2017

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29 September 2017

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Virus-producing cells determine the host protein profiles of HIV-1 virion cores

29 September 2017

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Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization

29 September 2017

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LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs

29 September 2017

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PD 404,182 is a virocidal small molecule that disrupts hepatitis C virus and human immunodeficiency virus

29 September 2017

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29 September 2017

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Activity of elvitegravir, a once-daily integrase inhibitor, against resistant HIV Type 1: results of a phase 2, randomized, controlled, dose-ranging clinical trial

29 September 2017

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29 September 2017

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29 September 2017

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An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule

29 September 2017

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Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.

29 September 2017

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29 September 2017

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Integrase and integration: biochemical activities of HIV-1 integrase

29 September 2017

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29 September 2017

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The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication

29 September 2017

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Integrase, LEDGF/p75 and HIV replication

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75.

29 September 2017

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29 September 2017

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Integrase inhibitors to treat HIV/AIDS.

29 September 2017

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Relationships between infectious titer, capsid protein levels, and reverse transcriptase activities of diverse human immunodeficiency virus type 1 isolates

29 September 2017

1 reference

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Interaction between human immunodeficiency virus type 1 reverse transcriptase and integrase proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767657

Requirement for integrase during reverse transcription of human immunodeficiency virus type 1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase.

29 September 2017

1 reference

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Formation of a human immunodeficiency virus type 1 core of optimal stability is crucial for viral replication

29 September 2017

1 reference

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A quantitative assay for HIV DNA integration in vivo

29 September 2017

1 reference

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Endogenous reverse transcriptase assays reveal synergy between combinations of the M184V and other drug resistance-conferring mutations in interactions with nucleoside analog triphosphates

29 September 2017

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Generation of high-titer pseudotyped retroviral vectors with very broad host range

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767657

Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767657

In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767657

LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767657

Genetic analyses of conserved residues in the carboxyl-terminal domain of human immunodeficiency virus type 1 integrase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3767657

Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection

3 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0074163

Symmetrical 1-pyrrolidineacetamide showing anti-HIV activity through a new binding site on HIV-1 integrase

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0074163

A sensitive and specific enzyme-based assay detecting HIV-1 virion fusion in primary T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0074163

Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0074163

Inhibition of HIV type 1 infection with a RANTES-IgG3 fusion protein

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24040198

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0074163

1 reference

ADS bibcode

2013PLoSO...874163B

0 references

1 reference

1 reference

PubMed publication ID

24040198

1 reference