Impact of apolipoprotein E on Alzheimer's disease (Q24567759)

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English	Impact of apolipoprotein E on Alzheimer's disease	scientific article

Statements

instance of

scholarly article

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title

Impact of apolipoprotein E on Alzheimer's disease (English)

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main subject

Alzheimer's disease

1 reference

based on heuristic

inferred from title

author

Robert O. Ryan

series ordinal

2

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author name string

Paul S Hauser

series ordinal

1

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language of work or name

English

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publication date

October 2013

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published in

Current Alzheimer Research

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volume

10

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issue

8

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page(s)

809-17

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cites work

ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

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The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: characterizing a new regulatory motif

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24 March 2017

ApoE promotes the proteolytic degradation of Abeta

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24 March 2017

The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins

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24 March 2017

Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease

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24 March 2017

Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation

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24 March 2017

Apolipoprotein A-I directly interacts with amyloid precursor protein and inhibits A beta aggregation and toxicity

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24 March 2017

Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease

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24 March 2017

Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions

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24 March 2017

Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms

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24 March 2017

Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E

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24 March 2017

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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24 March 2017

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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24 March 2017

Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain

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24 March 2017

The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease

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24 March 2017

ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins

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PubMed Central

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24 March 2017

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

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PubMed Central

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24 March 2017

LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins

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24 March 2017

Isoform-specific binding of apolipoprotein E to beta-amyloid

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PubMed Central

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24 March 2017

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

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PubMed Central

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7 April 2017

Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide

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PubMed Central

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27 September 2017

APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.

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PubMed Central

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27 September 2017

Preventing Alzheimer's disease

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PubMed Central

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27 September 2017

Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease

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PubMed Central

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27 September 2017

Purified and synthetic Alzheimer's amyloid beta (Aβ) prions

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PubMed Central

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27 September 2017

Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice

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PubMed Central

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27 September 2017

Clusterin in Alzheimer's disease

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PubMed Central

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27 September 2017

Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis

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PubMed Central

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27 September 2017

Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.

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PubMed Central

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27 September 2017

Nuclear receptors as therapeutic targets for Alzheimer's disease

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PubMed Central

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27 September 2017

An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia

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PubMed Central

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27 September 2017

Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease

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PubMed Central

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27 September 2017

Apolipoprotein E: From lipid transport to neurobiology

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PubMed Central

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27 September 2017

ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice

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PubMed Central

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27 September 2017

Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice

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PubMed Central

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27 September 2017

The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration

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PubMed Central

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27 September 2017

Brain lipid metabolism, apolipoprotein E and the pathophysiology of Alzheimer's disease

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PubMed Central

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27 September 2017

Understanding the basis for the association of apoE4 with Alzheimer's disease: opening the door for therapeutic approaches

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PubMed Central

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27 September 2017

Clusterin: a forgotten player in Alzheimer's disease

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PubMed Central

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27 September 2017

Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions

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PubMed Central

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27 September 2017

Greasing the wheels of Abeta clearance in Alzheimer's disease: the role of lipids and apolipoprotein E.

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27 September 2017

Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease

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27 September 2017

Human apolipoprotein A-I binds amyloid-beta and prevents Abeta-induced neurotoxicity

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27 September 2017

Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure

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27 September 2017

Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in mice

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27 September 2017

PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease

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27 September 2017

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.

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27 September 2017

24S-hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression

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27 September 2017

Assembly of high-density lipoprotein

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27 September 2017

Low density lipoprotein receptor-related proteins (LRPs), Alzheimer's and cognition

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27 September 2017

Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer

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27 September 2017

A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes

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PubMed Central

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27 September 2017

Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

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PubMed Central

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27 September 2017

Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

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PubMed Central

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27 September 2017

Lipoproteins in the central nervous system

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PubMed Central

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27 September 2017

Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides

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PubMed Central

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27 September 2017

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

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PubMed Central

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27 September 2017

Molecular basis of exchangeable apolipoprotein function

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27 September 2017

Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

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PubMed Central

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27 September 2017

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

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PubMed Central

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27 September 2017

The amphipathic alpha helix: a multifunctional structural motif in plasma apolipoproteins

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PubMed Central

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27 September 2017

Apolipoprotein E: structure-function relationships

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PubMed Central

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27 September 2017

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

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PubMed Central

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27 September 2017

Abnormal in vivo metabolism of apolipoprotein E4 in humans

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PubMed Central

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27 September 2017

Cell biology. A unifying role for prions in neurodegenerative diseases

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30 May 2018

Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.

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PubMed Central

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30 May 2018

Lipid binding-induced conformational changes in the N-terminal domain of human apolipoprotein E.

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PubMed Central

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30 May 2018

Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE.

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PubMed Central

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30 May 2018

Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins

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PubMed Central

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30 May 2018

Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains

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30 May 2018

Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112.

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PubMed Central

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30 May 2018

Molecular dynamics simulation and computational two-dimensional infrared spectroscopic study of model amyloid β-peptide oligomers

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PubMed Central

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28 November 2018

Medicine. Old drug, new hope for Alzheimer's disease

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28 November 2018

Transformation of amyloid β(1-40) oligomers into fibrils is characterized by a major change in secondary structure

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PubMed Central

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28 November 2018

Reduced levels of human apoE4 protein in an animal model of cognitive impairment

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PubMed Central

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28 November 2018

Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.

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PubMed Central

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28 November 2018

Antiparallel beta-sheet: a signature structure of the oligomeric amyloid beta-peptide

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retrieved

28 November 2018

Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995977

retrieved

28 November 2018

Interaction with amyloid beta peptide compromises the lipid binding function of apolipoprotein E.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995977

retrieved

28 November 2018

Lipid-induced extension of apolipoprotein E helix 4 correlates with low density lipoprotein receptor binding ability.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995977

retrieved

28 November 2018

Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995977

retrieved

28 November 2018

Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995977

retrieved

28 November 2018

The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995977

retrieved

28 November 2018

The structure of human apolipoprotein E2, E3 and E4 in solution 1. Tertiary and quaternary structure.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995977

retrieved

28 November 2018

Fluorescence resonance energy transfer analysis of apolipoprotein E C-terminal domain and amyloid beta peptide (1-42) interaction

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995977

retrieved

28 November 2018

ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995977

retrieved

28 November 2018

Helix orientation of the functional domains in apolipoprotein e in discoidal high density lipoprotein particles

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995977

retrieved

28 November 2018

Domain structure and lipid interaction in human apolipoproteins A-I and E, a general model

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995977

retrieved

28 November 2018

Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995977

retrieved

28 November 2018

Lipid association-induced N- and C-terminal domain reorganization in human apolipoprotein E3.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995977

retrieved

28 November 2018

Characterization and functional studies of lipoproteins, lipid transfer proteins, and lecithin:cholesterol acyltransferase in CSF of normal individuals and patients with Alzheimer's disease

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995977

retrieved

28 November 2018

Apolipoprotein E and Alzheimer's disease. The tip of the susceptibility iceberg

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995977

retrieved

28 November 2018

Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995977

retrieved

28 November 2018

Protective effect of apoE epsilon 2 in Alzheimer's disease.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3995977

retrieved

28 November 2018

Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/23919769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The low density lipoprotein receptor active conformation of apolipoprotein E. Helix organization in n-terminal domain-phospholipid disc particles

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/23919769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of apolipoprotein E structure by domain interaction: differences in lipid-bound and lipid-free forms

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/23919769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.2174/15672050113109990156

0 references

Fatcat ID

release_j32clc5ilrhy5fgnpwmickt7ee

1 reference

stated in

Fatcat

reference URL

https://api.fatcat.wiki/v0/release/j32clc5ilrhy5fgnpwmickt7ee

retrieved

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

3995977

0 references

PubMed publication ID

23919769

0 references

 

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