LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins (Q28595076)

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19065001%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins (English)

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19065001%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

0 references

1 reference

lecithin cholesterol acyltransferase

1 reference

GOA release 2020-03-11

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19065001%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

author name string

Veronica Hirsch-Reinshagen

2 references

1 February 2017

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18 January 2020

James Donkin

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19065001%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Jennifer Chan

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19065001%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Anna Wilkinson

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19065001%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Jianjia Fan

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19065001%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Jan Albert Kuivenhoven

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19065001%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Dieter Lütjohann

2 references

1 February 2017

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18 January 2020

Haydn Pritchard

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19065001%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

John S Parks

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19065001%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Cheryl L Wellington

1 reference

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18 January 2020

publication date

8 December 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19065001%20AND%20SRC:MED&resulttype=core&format=json

Journal of Lipid Research

18 January 2020

published in

2 references

1 February 2017

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18 January 2020

2 references

1 February 2017

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18 January 2020

2 references

1 February 2017

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18 January 2020

page(s)

885-893

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19065001%20AND%20SRC:MED&resulttype=core&format=json

Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins

18 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Abnormal phospholipid composition impairs HDL biogenesis and maturation in mice lacking Abca1

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Effect of apolipoprotein A-I deficiency on lecithin:cholesterol acyltransferase activation in mouse plasma

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Human lecithin-cholesterol acyltransferase gene: complete gene sequence and sites of expression

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Lecithin cholesterol acyltransferase in human cerebrospinal fluid: reduced level in patients with multiple sclerosis and evidence of direct synthesis in the brain

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Lipoproteins in the central nervous system

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Secretion of lecithin:cholesterol acyltransferase by brain neuroglial cell lines

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Regulation of lecithin cholesterol acyltransferase activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Expression of human lecithin-cholesterol acyltransferase in transgenic mice. Effect of human apolipoprotein AI and human apolipoprotein all on plasma lipoprotein cholesterol metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Tissue-specific expression, developmental regulation, and chromosomal mapping of the lecithin: cholesterol acyltransferase gene. Evidence for expression in brain and testes as well as liver

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Lecithin-cholesterol acyltransferase in the metabolism of high-density lipoproteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Apolipoproteins in human cerebrospinal fluid

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Characterization of four lipoprotein classes in human cerebrospinal fluid

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Nascent astrocyte particles differ from lipoproteins in CSF.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Recombinant lecithin:cholesterol acyltransferase containing a Thr123-->Ile mutation esterifies cholesterol in low density lipoprotein but not in high density lipoprotein

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Expression and characterization of recombinant human lecithin:cholesterol acyltransferase.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Synthetic peptide analogs of apolipoproteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Cellular localization of apolipoprotein D and lecithin:cholesterol acyltransferase mRNA in rhesus monkey tissues by in situ hybridization.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Chicken lecithin-cholesterol acyltransferase. Molecular characterization reveals unusual structure and expression pattern

3 June 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800584-JLR200

Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800584-JLR200

Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800584-JLR200

Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800584-JLR200

Functional LCAT deficiency in human apolipoprotein A-I transgenic, SR-BI knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800584-JLR200

ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800584-JLR200

Tissue-specific expression of the human gene for lecithin: cholesterol acyltransferase in transgenic mice alters blood lipids, lipoproteins and lipases towards a less atherogenic profile.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800584-JLR200

Lecithin:cholesterol acyltransferase overexpression generates hyperalpha-lipoproteinemia and a nonatherogenic lipoprotein pattern in transgenic rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800584-JLR200

Apolipoprotein C-I expression in the brain in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800584-JLR200

Disruption of the murine lecithin:cholesterol acyltransferase gene causes impairment of adrenal lipid delivery and up-regulation of scavenger receptor class B type I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800584-JLR200

Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800584-JLR200

Characterization and functional studies of lipoproteins, lipid transfer proteins, and lecithin:cholesterol acyltransferase in CSF of normal individuals and patients with Alzheimer's disease

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666175

Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

27 November 2018

1 reference

12 December 2020

Characterization of subpopulations of lipoprotein particles isolated from human cerebrospinal fluid

1 reference

12 December 2020

Overexpression of human lecithin cholesterol acyltransferase leads to hyperalphalipoproteinemia in transgenic mice

1 reference

12 December 2020

Astrocytes synthesize and secrete the lipophilic ligand carrier apolipoprotein D

1 reference

12 December 2020

Biochemical characterization of Alzheimer's soluble amyloid beta protein in human cerebrospinal fluid: association with high density lipoproteins

1 reference

12 December 2020

Role of LCAT in HDL remodeling: investigation of LCAT deficiency states

1 reference

12 December 2020

Activation of lecithin cholesterol acyltransferase by human apolipoprotein E in discoidal complexes with lipids

1 reference

12 December 2020

10.1194/JLR.M800584-JLR200

Identifiers

DOI

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19065001%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19065001%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

2 references

1 February 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19065001%20AND%20SRC:MED&resulttype=core&format=json