ApoE promotes the proteolytic degradation of Abeta (Q24651102)

object named as

David M Holtzman

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author name string

Qingguang Jiang

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C Y Daniel Lee

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Shweta Mandrekar

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Brandy Wilkinson

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Paige Cramer

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Noam Zelcer

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Karen Mann

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Bruce Lamb

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Timothy M Willson

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Jon L Collins

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Jill C Richardson

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Jonathan D Smith

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Thomas A Comery

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David Riddell

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Gary E Landreth

Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo

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language of work or name

English

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publication date

12 June 2008

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681-93

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cites work

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The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease

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Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain

7 April 2017

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Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

7 April 2017

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7 April 2017

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Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.

7 April 2017

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Expression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatment

28 September 2017

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Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

28 September 2017

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28 September 2017

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Self-assembly of HEK cell-secreted ApoE particles resembles ApoE enrichment of lipoproteins as a ligand for the LDL receptor-related protein

28 September 2017

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28 September 2017

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Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta

28 September 2017

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28 September 2017

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28 September 2017

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Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism.

28 September 2017

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28 September 2017

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A nontransgenic mouse model shows inducible amyloid-beta (Abeta) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade

28 September 2017

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28 September 2017

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LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

28 September 2017

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In vivo effects of ApoE and clusterin on amyloid-beta metabolism and neuropathology

28 September 2017

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Enlargement of high density lipoprotein in mice via liver X receptor activation requires apolipoprotein E and is abolished by cholesteryl ester transfer protein expression

28 September 2017

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Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide Secretion

28 September 2017

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Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels

28 September 2017

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Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide

28 September 2017

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Role of apoe/Abeta interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy

28 September 2017

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ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein

28 September 2017

1 reference

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Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

28 September 2017

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Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides

28 September 2017

1 reference

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Opposite roles of apolipoprotein E in normal brains and in Alzheimer's disease.

28 September 2017

1 reference

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Apolipoprotein E alleles as risk factors in Alzheimer's disease

28 September 2017

1 reference

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Influence of the susceptibility genes apolipoprotein E-epsilon 4 and apolipoprotein E-epsilon 2 on the rate of disease expressivity of late-onset Alzheimer's disease

28 September 2017

1 reference

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22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion

28 September 2017

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Characterization of four lipoprotein classes in human cerebrospinal fluid

30 May 2018

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Isolation and characterization of apolipoproteins from murine microglia. Identification of a low density lipoprotein-like apolipoprotein J-rich but E-poor spherical particle

30 May 2018

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Lipid binding-induced conformational changes in the N-terminal domain of human apolipoprotein E.

30 May 2018

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Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493297

Solvent effects on self-assembly of beta-amyloid peptide

30 May 2018

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The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease

30 May 2018

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The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo.

28 November 2018

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Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.

28 November 2018

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Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice

28 November 2018

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Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease

28 November 2018

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28 November 2018

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28 November 2018

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ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493297

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493297

ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo

28 November 2018

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Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

28 November 2018

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28 November 2018

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Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma

28 November 2018

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Metabolic regulation of brain Abeta by neprilysin

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493297

Conformation of apolipoprotein E both in free and in lipid-bound form may determine the avidity of triglyceride-rich lipoproteins to the LDL receptor: structural and kinetic study

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493297

Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493297

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493297

Purification of apolipoprotein E attenuates isoform-specific binding to beta-amyloid

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18549781

12 December 2020

inferred from PubMed ID database lookup

Brain expression of apolipoproteins E, J, and A-I in Alzheimer's disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18549781

12 December 2020

inferred from PubMed ID database lookup

A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.NEURON.2008.04.010

7 January 2021

inferred from DOI database lookup

Liver X receptor-mediated gene regulation and cholesterol homeostasis in brain: relevance to Alzheimer's disease therapeutics

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.NEURON.2008.04.010

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1016/J.NEURON.2008.04.010

1 reference

1 reference

1 reference

PubMed publication ID

18549781

1 reference