Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease (Q24336432)

RAB29, member RAS oncogene family

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Leucine rich repeat kinase 2

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BAG cochaperone 5

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negative regulation of neuron projection development

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BCL2-associated athanogene 5

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Ras-related protein Rab-7L1

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Leucine-rich repeat kinase 2

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1 reference

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Evy Lobbestael

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Maciej Olszewski

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David N Hauser

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Andres M Lozano

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Mark R Cookson

object named as

Mark R Cookson

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Alice Kaganovich

object named as

Alice Kaganovich

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Alexandra Beilina

object named as

Alexandria Beilina

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Michele T M Hu

1 reference

ORCID Public Data File 2021

Daniela Berg

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ORCID Public Data File 2021

author name string

Iakov N Rudenko

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Laura Civiero

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Hien Chau

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Suneil K Kalia

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Lorraine V Kalia

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Ruth Chia

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Kelechi Ndukwe

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Jinhui Ding

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Mike A Nalls

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Ravindran Kumaran

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Lois E Greene

Proceedings of the National Academy of Sciences of the United States of America

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language of work or name

English

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publication date

18 February 2014

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published in

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volume

111

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issue

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page(s)

2626-31

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cites work

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk

1 reference

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Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

19 March 2017

1 reference

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The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation

19 March 2017

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ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2

19 March 2017

1 reference

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GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1

19 March 2017

1 reference

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Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

19 March 2017

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A two-stage meta-analysis identifies several new loci for Parkinson's disease

19 March 2017

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Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease

19 March 2017

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Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

19 March 2017

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Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

19 March 2017

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Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

19 March 2017

1 reference

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14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

19 March 2017

1 reference

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Genome-wide association study reveals genetic risk underlying Parkinson's disease

19 March 2017

1 reference

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LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

19 March 2017

1 reference

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Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

19 March 2017

1 reference

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Localization of LRRK2 to membranous and vesicular structures in mammalian brain

19 March 2017

1 reference

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

19 March 2017

1 reference

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BAG5 inhibits parkin and enhances dopaminergic neuron degeneration

19 March 2017

1 reference

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19 March 2017

Mechanisms of mitophagy

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Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation

19 March 2017

1 reference

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Depletion of GAK/auxilin 2 inhibits receptor-mediated endocytosis and recruitment of both clathrin and clathrin adaptors

19 March 2017

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Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease

19 March 2017

1 reference

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Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

19 March 2017

1 reference

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High-resolution network biology: connecting sequence with function

7 April 2017

1 reference

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Evaluation of Parkinson disease risk variants as expression-QTLs

27 September 2017

1 reference

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Towards unveiling the genetics of neurodegenerative diseases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3932908

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

27 September 2017

1 reference

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Sorting nexins provide diversity for retromer-dependent trafficking events

27 September 2017

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A generalizable hypothesis for the genetic architecture of disease: pleomorphic risk loci

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3932908

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

27 September 2017

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A comparative study of Lrrk2 function in primary neuronal cultures

27 September 2017

1 reference

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Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3932908

Parkinson's disease: insights from pathways

27 September 2017

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The pursuit of genome-wide association studies: where are we now?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3932908

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3932908

The BAG proteins: a ubiquitous family of chaperone regulators

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3932908

Canonical interaction of cyclin G associated kinase with adaptor protein 1 regulates lysosomal enzyme sorting

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3932908

Sucrose-induced vacuolation results in increased expression of cholesterol biosynthesis and lysosomal genes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3932908

High Ca2+-phosphate transfection efficiency in low-density neuronal cultures

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3932908

Recruitment dynamics of GAK and auxilin to clathrin-coated pits during endocytosis

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24510904

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1318306111

1 reference

ADS bibcode

2014PNAS..111.2626B

0 references

1 reference

1 reference

PubMed publication ID

24510904

1 reference