BAG5 inhibits parkin and enhances dopaminergic neuron degeneration (Q24322908)

BCL2-associated athanogene 5

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

1 reference

Andres M Lozano

0 references

Edward A. Fon

object named as

Edward A Fon

0 references

author name string

Suneil K Kalia

0 references

Sang Lee

0 references

Patrice D Smith

0 references

Li Liu

0 references

Stephen J Crocker

0 references

Thorhildur E Thorarinsdottir

0 references

John R Glover

0 references

David S Park

The carboxyl-terminal lobe of Hsc70 ATPase domain is sufficient for binding to BAG1.

0 references

language of work or name

English

0 references

publication date

16 December 2004

0 references

0 references

0 references

0 references

931-45

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Parkin suppresses wild-type alpha-synuclein-induced toxicity in SHSY-5Y cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Are ubiquitination pathways central to Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Parkinson's disease: mechanisms and models

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

α-Synuclein in Lewy bodies

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Structural analysis of BAG1 cochaperone and its interactions with Hsc70 heat shock protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Molecular chaperone targeting and regulation by BAG family proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Genetic clues to the pathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Targeting programmed cell death in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Heat-shock proteins as regulators of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Parkinson's disease. First of two parts

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

c-Jun mediates axotomy-induced dopamine neuron death in vivo

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Modulation of in vivo HSP70 chaperone activity by Hip and Bag-1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

BAG4/SODD protein contains a short BAG domain

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Parkin accumulation in aggresomes due to proteasome impairment

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Ubiquitylation of BAG-1 suggests a novel regulatory mechanism during the sorting of chaperone substrates to the proteasome

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Prediction of novel Bag-1 homologs based on structure/function analysis identifies Snl1p as an Hsp70 co-chaperone in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Parkin cleaves intracellular alpha-synuclein inclusions via the activation of calpain

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Inhibition of proteasomal activity causes inclusion formation in neuronal and non-neuronal cells overexpressing Parkin

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

BAG-1 modulates the chaperone activity of Hsp70/Hsc70

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Mammalian protein RAP46: an interaction partner and modulator of 70kDa heat shock proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

GrpE-like regulation of the Hsc70 chaperone by the anti-apoptotic protein BAG-1

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

BAG1 over-expression in brain protects against stroke.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

1 reference

7 January 2021

Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021

High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026

7 January 2021