ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2 (Q24307742)

ADP ribosylation factor GTPase activating protein 1

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ADP-ribosylation factor GTPase activating protein 1

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Leucine-rich repeat kinase 2

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Ted M Dawson

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author name string

Yulan Xiong

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Changqing Yuan

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Rong Chen

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Valina L Dawson

ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2

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language of work or name

English

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publication date

14 March 2012

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published in

Journal of Neuroscience

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volume

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issue

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page(s)

3877-86

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cites work

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LRRK2 regulates synaptic vesicle endocytosis

19 March 2017

1 reference

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The R1441C mutation of LRRK2 disrupts GTP hydrolysis

19 March 2017

1 reference

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Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

19 March 2017

1 reference

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Localization of LRRK2 to membranous and vesicular structures in mammalian brain

19 March 2017

1 reference

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Kinase activity of mutant LRRK2 mediates neuronal toxicity

19 March 2017

1 reference

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Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

19 March 2017

1 reference

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

19 March 2017

1 reference

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Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

19 March 2017

1 reference

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

19 March 2017

1 reference

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The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior

19 March 2017

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LRRK2 in Parkinson's disease: protein domains and functional insights

19 March 2017

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

19 March 2017

1 reference

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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

19 March 2017

1 reference

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Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models

7 April 2017

1 reference

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Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

27 September 2017

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The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

27 September 2017

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Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

27 September 2017

1 reference

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Models for the functions of Arf GAPs

27 September 2017

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27 September 2017

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GTPase activity plays a key role in the pathobiology of LRRK2.

27 September 2017

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Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.

27 September 2017

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CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

27 September 2017

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A Drosophila model for LRRK2-linked parkinsonism

27 September 2017

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The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319331

Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants

27 September 2017

1 reference

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Widespread expression of Huntington's disease gene (IT15) protein product

27 September 2017

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Catecholamine-containing neurons in Drosophila melanogaster: distribution and development.

30 May 2018

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Targeted gene expression in Drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylase

30 May 2018

1 reference

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10.1523/JNEUROSCI.4566-11.2012

29 November 2018

Identifiers

DOI

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PubMed publication ID

22423108

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