Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP (Q24293723)

Protein kinase AMP-activated catalytic subunit alpha 1

1 reference

Leucine rich repeat kinase 2

1 reference

Two pore segment channel 1

1 reference

positive regulation of autophagy

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0 references

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Patricia Gómez-Suaga

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Berta Luzón-Toro

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Dev Churamani

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Ling Zhang

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Duncan Bloor-Young

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Philip G Woodman

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Grant C Churchill

Creative Commons Attribution-NonCommercial 3.0 Unported

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language of work or name

English

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publication date

1 February 2012

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published in

Human Molecular Genetics

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volume

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issue

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page(s)

511-25

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1 reference

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259011

describes a project that uses

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3259011/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

on focus list of Wikimedia project

ScienceSource

0 references

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HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

7 April 2017

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10 May 2017

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Genetic Analysis of Pathways to Parkinson Disease

27 September 2017

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27 September 2017

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Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

27 September 2017

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Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.

27 September 2017

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GTPase activity plays a key role in the pathobiology of LRRK2.

27 September 2017

1 reference

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Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking

27 September 2017

1 reference

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Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

27 September 2017

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Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

27 September 2017

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Combined kinase inhibition modulates parkin inactivation.

27 September 2017

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Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

27 September 2017

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Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

27 September 2017

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The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity

27 September 2017

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27 September 2017

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Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor

27 September 2017

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Endoplasmic reticulum, Bcl-2 and Ca2+ handling in apoptosis

27 September 2017

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STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase

27 September 2017

1 reference

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Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259011

Immediate early response of the p62 gene encoding a non-proteasomal multiubiquitin chain binding protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259011

Extracellular nucleotides stimulate proliferation in MCF-7 breast cancer cells via P2-purinoceptors

27 September 2017

1 reference

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Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types

27 September 2017

1 reference

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NAADP: a universal Ca2+ trigger

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259011

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

30 May 2018

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NAADP induces pH changes in the lumen of acidic Ca2+ stores

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259011

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

30 May 2018

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Transmembrane-domain determinants for SNARE-mediated membrane fusion

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259011

Monitoring autophagic degradation of p62/SQSTM1.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259011

Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259011

29 November 2018

Identifiers

DOI

10.1093/HMG/DDR481

1 reference

1 reference

1 reference

PubMed publication ID

22012985

1 reference