Phosphorylated and unphosphorylated serine 13 of CDC37 stabilize distinct interactions between its client and HSP90 binding domains (Q36824214)

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scientific article published on 11 February 2015

Language	Label	Description	Also known as
English	Phosphorylated and unphosphorylated serine 13 of CDC37 stabilize distinct interactions between its client and HSP90 binding domains	scientific article published on 11 February 2015

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Phosphorylated and unphosphorylated serine 13 of CDC37 stabilize distinct interactions between its client and HSP90 binding domains (English)

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

phosphorylation

0 references

author name string

Wenjun Liu

1

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Ralf Landgraf

2

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

language of work or name

0 references

publication date

11 February 2015

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

54

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

7

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

1493-1504

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Correlations between predicted protein disorder and post-translational modifications in plants

1 reference

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Structural changes of CFTR R region upon phosphorylation: a plastic platform for intramolecular and intermolecular interactions

1 reference

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Resilience of death: intrinsic disorder in proteins involved in the programmed cell death

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Scalable web services for the PSIPRED Protein Analysis Workbench.

1 reference

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The allosteric mechanism induced by protein kinase A (PKA) phosphorylation of dematin (band 4.9)

1 reference

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29 September 2017

Novel interaction between the co-chaperone Cdc37 and Rho GTPase exchange factor Vav3 promotes androgen receptor activity and prostate cancer growth

1 reference

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Conditional disorder in chaperone action

1 reference

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Diverse functional manifestations of intrinsic structural disorder in molecular chaperones.

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Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

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Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine

1 reference

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Long-range modulation of chain motions within the intrinsically disordered transactivation domain of tumor suppressor p53.

1 reference

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Binary classification of protein molecules into intrinsically disordered and ordered segments

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Intrinsically disordered chaperones in plants and animals.

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PONDR-FIT: a meta-predictor of intrinsically disordered amino acids

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Geldanamycin selectively targets the nascent form of ERBB3 for degradation

1 reference

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Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery

1 reference

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29 September 2017

Reconciling binding mechanisms of intrinsically disordered proteins.

1 reference

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29 September 2017

Targeting CDC37: an alternative, kinase-directed strategy for disruption of oncogenic chaperoning

1 reference

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The Hsp90 mosaic: a picture emerges

1 reference

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29 September 2017

The human Cdc37.Hsp90 complex studied by heteronuclear NMR spectroscopy

1 reference

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29 September 2017

Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors

1 reference

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29 September 2017

Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.

1 reference

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29 September 2017

14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers

1 reference

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29 September 2017

Targeting Cdc37 inhibits multiple signaling pathways and induces growth arrest in prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840409

29 September 2017

Posttranslational modifications and subcellular localization signals: indicators of sequence regions without inherent 3D structure?

1 reference

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29 September 2017

Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions.

1 reference

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29 September 2017

Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturation

1 reference

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Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis

1 reference

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29 September 2017

Structure of an Hsp90-Cdc37-Cdk4 complex.

1 reference

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29 September 2017

Flexible nets. The roles of intrinsic disorder in protein interaction networks.

1 reference

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29 September 2017

Intrinsically unstructured proteins and their functions

1 reference

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29 September 2017

CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37.

1 reference

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Prediction and Functional Analysis of Native Disorder in Proteins from the Three Kingdoms of Life

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29 September 2017

The importance of intrinsic disorder for protein phosphorylation

1 reference

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29 September 2017

The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840409

29 September 2017

Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840409

29 September 2017

Identification of Cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase

1 reference

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The Cdc37 protein kinase-binding domain is sufficient for protein kinase activity and cell viability

1 reference

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Intrinsic disorder in cell-signaling and cancer-associated proteins

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Protein kinase CK2: a challenge to canons

1 reference

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Role of p50/CDC37 in hepadnavirus assembly and replication

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Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.

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29 September 2017

Structure, function, and mechanism of the Hsp90 molecular chaperone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840409

29 September 2017

Intrinsically disordered protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840409

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Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set

1 reference

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Sequence complexity of disordered protein

1 reference

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Functional interaction of human Cdc37 with the androgen receptor but not with the glucocorticoid receptor

1 reference

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Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

1 reference

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29 September 2017

Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840409

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Protein secondary structure prediction based on position-specific scoring matrices

1 reference

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29 September 2017

p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

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29 September 2017

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840409

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840409

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Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas

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27 June 2018

Phosphorylation destabilizes alpha-helices.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840409

27 June 2018

Potential conformational heterogeneity of p53 bound to S100B(ββ).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840409

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Analysis of the CK2-dependent phosphorylation of serine 13 in Cdc37 using a phospho-specific antibody and phospho-affinity gel electrophoresis

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5 September 2018

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5 September 2018

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A positive feedback loop between protein kinase CKII and Cdc37 promotes the activity of multiple protein kinases

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5 September 2018

Effect of phosphorylation on the structure and fold of transactivation domain of p53.

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Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria.

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Induction of human Cdc37 in prostate cancer correlates with the ability of targeted Cdc37 expression to promote prostatic hyperplasia

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4 December 2018

Structural biology. Versatility from protein disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/25619116

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of boundaries between intrinsically ordered and disordered protein regions

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https://pubmed.ncbi.nlm.nih.gov/25619116

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A conserved helix-unfolding motif in the naturally unfolded proteins

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https://pubmed.ncbi.nlm.nih.gov/25619116

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence Data Analysis for Long Disordered Regions Prediction in the Calcineurin Family

1 reference

https://pubmed.ncbi.nlm.nih.gov/25619116

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Posttranslational modifications affect the interaction of S100 proteins with tumor suppressor p53

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https://pubmed.ncbi.nlm.nih.gov/25619116

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation stabilizes the N-termini of alpha-helices

1 reference

https://pubmed.ncbi.nlm.nih.gov/25619116

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alternative O-GlcNAcylation/O-phosphorylation of Ser16 induce different conformational disturbances to the N terminus of murine estrogen receptor beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/25619116

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicting Protein Disorder for N-, C-, and Internal Regions

1 reference

https://pubmed.ncbi.nlm.nih.gov/25619116

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI501129G

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

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