Novel interaction between the co-chaperone Cdc37 and Rho GTPase exchange factor Vav3 promotes androgen receptor activity and prostate cancer growth (Q36635865)

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scientific article published on 31 December 2012

Language	Label	Description	Also known as
English	Novel interaction between the co-chaperone Cdc37 and Rho GTPase exchange factor Vav3 promotes androgen receptor activity and prostate cancer growth	scientific article published on 31 December 2012

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Novel interaction between the co-chaperone Cdc37 and Rho GTPase exchange factor Vav3 promotes androgen receptor activity and prostate cancer growth (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

molecular chaperones

0 references

prostate cancer

1 reference

based on heuristic

inferred from title

author name string

Fayi Wu

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Stephanie O Peacock

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Shuyun Rao

3

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Sandra K Lemmon

4

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Kerry L Burnstein

5

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

language of work or name

0 references

publication date

31 December 2012

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

288

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

8

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

5463-5474

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Vav3-rac1 signaling regulates prostate cancer metastasis with elevated Vav3 expression correlating with prostate cancer progression and posttreatment recurrence

1 reference

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Clinical significance of increased guanine nucleotide exchange factor Vav3 expression in human gastric cancer

1 reference

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A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer

1 reference

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Multicenter phase II trial of the heat shock protein 90 inhibitor, retaspimycin hydrochloride (IPI-504), in patients with castration-resistant prostate cancer

1 reference

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Structural features discriminate androgen receptor N/C terminal and coactivator interactions

1 reference

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Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer

1 reference

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Bypass Mechanisms of the Androgen Receptor Pathway in Therapy-Resistant Prostate Cancer Cell Models

1 reference

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Targeting the dynamic HSP90 complex in cancer

1 reference

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Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

1 reference

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Update on Hsp90 inhibitors in clinical trial.

1 reference

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Mechanisms mediating androgen receptor reactivation after castration

1 reference

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A phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancer

1 reference

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The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.

1 reference

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Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.

1 reference

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Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone

1 reference

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Targeted overexpression of vav3 oncogene in prostatic epithelium induces nonbacterial prostatitis and prostate cancer

1 reference

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Analyzing real-time PCR data by the comparative C(T) method

1 reference

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Targeting Cdc37 inhibits multiple signaling pathways and induces growth arrest in prostate cancer cells

1 reference

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Ligand-independent activation of androgen receptors by Rho GTPase signaling in prostate cancer

1 reference

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Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas.

1 reference

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30 September 2017

Cooperative interactions between androgen receptor (AR) and heat-shock protein 27 facilitate AR transcriptional activity

1 reference

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30 September 2017

Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex

1 reference

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30 September 2017

Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer

1 reference

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30 September 2017

Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity

1 reference

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30 September 2017

CK2 binds, phosphorylates, and regulates its pivotal substrate Cdc37, an Hsp90-cochaperone

1 reference

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Identification of novel binding partners for tuberous sclerosis complex 2 (TSC2) by yeast two-hybrid approach.

1 reference

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30 September 2017

Constantly updated knowledge of Hsp90.

1 reference

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30 September 2017

Hsp90 and Cdc37 -- a chaperone cancer conspiracy.

1 reference

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The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)

1 reference

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Cdc37 goes beyond Hsp90 and kinases

1 reference

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Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37.

1 reference

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Identification of Cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase

1 reference

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The Cdc37 protein kinase-binding domain is sufficient for protein kinase activity and cell viability

1 reference

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Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity

1 reference

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Role of p50/CDC37 in hepadnavirus assembly and replication

1 reference

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Androgen receptor (AR) coregulators: an overview

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Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.

1 reference

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Molecular chaperones in the cytosol: from nascent chain to folded protein

1 reference

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1 reference

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Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation

1 reference

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Functional interaction of human Cdc37 with the androgen receptor but not with the glucocorticoid receptor

1 reference

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Regulatory and signaling properties of the Vav family

1 reference

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Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins

1 reference

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A new human prostate carcinoma cell line, 22Rv1.

1 reference

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Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor2).

1 reference

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Antiproliferative effect of 1alpha,25-dihydroxyvitamin D3 in human prostate cancer cell line LNCaP involves reduction of cyclin-dependent kinase 2 activity and persistent G1 accumulation

1 reference

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Cdc37 is a molecular chaperone with specific functions in signal transduction

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581368

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A positive feedback loop between protein kinase CKII and Cdc37 promotes the activity of multiple protein kinases

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Androgen Receptor (AR) Coregulators: An Overview

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.390963

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Induction of human Cdc37 in prostate cancer correlates with the ability of targeted Cdc37 expression to promote prostatic hyperplasia

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The molecular chaperone Cdc37 is required for Ste11 function and pheromone-induced cell cycle arrest

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.390963

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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