Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. (Q36940315)

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24 December 2019

title

Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37 (English)

1 reference

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24 December 2019

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Chrisostomos Prodromou

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24 December 2019

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24 December 2019

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Andrew Truman

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Len Neckers

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Cara K Vaughan

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Mehdi Mollapour

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Jennifer R Smith

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Barry Panaretou

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Peter W Piper

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Paul Workman

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publication date

1 September 2008

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volume

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issue

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24 December 2019

page(s)

886-895

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describes a project that uses

24 December 2019

ImageQuant

object named as

ImageQuant

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inferred from PubMed Central ID database lookup

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

cites work

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CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37.

29 September 2017

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Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery

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The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)

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Identification of a conserved sequence motif that promotes Cdc37 and cyclin D1 binding to Cdk4.

29 September 2017

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Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37.

29 September 2017

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Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1

29 September 2017

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The Cdc37 protein kinase-binding domain is sufficient for protein kinase activity and cell viability

29 September 2017

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Protein kinase CK2: structure, regulation and role in cellular decisions of life and death

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Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase

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29 September 2017

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A constitutively "phosphorylated" guanylyl cyclase-linked atrial natriuretic peptide receptor mutant is resistant to desensitization

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Possible role for serine/threonine phosphorylation in the regulation of the heteroprotein complex between the hsp90 stress protein and the pp60v-src tyrosine kinase

29 September 2017

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29 September 2017

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4 September 2018

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Definition of protein kinase sequence motifs that trigger high affinity binding of Hsp90 and Cdc37.

4 September 2018

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Biochemical and structural studies of the interaction of Cdc37 with Hsp90.

4 September 2018

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Functional Dissection of Cdc37: Characterization of Domain Structure and Amino Acid Residues Critical for Protein Kinase Binding

4 September 2018

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High Affinity Binding of Hsp90 Is Triggered by Multiple Discrete Segments of Its Kinase Clients

4 September 2018

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Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors

4 September 2018

1 reference

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A positive feedback loop between protein kinase CKII and Cdc37 promotes the activity of multiple protein kinases

4 September 2018

1 reference

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Evidence that protein phosphatase 5 functions to negatively modulate the maturation of the Hsp90-dependent heme-regulated eIF2alpha kinase

4 September 2018

1 reference

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Interaction of the Rous sarcoma virus protein pp60src with the cellular proteins pp50 and pp90.

4 September 2018

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Expressed as the sole Hsp90 of yeast, the alpha and beta isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90beta generates sensitivity to the Hsp90 inhibitor radicicol

4 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18922470

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2008.07.021

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18922470%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

1 reference

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24 December 2019

PubMed publication ID

18922470

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18922470%20AND%20SRC:MED&resulttype=core&format=json