APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice. (Q35337169)

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English	APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice.	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice. (English)

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

author name string

De-shan Liu

1

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Europe PubMed Central

PubMed publication ID

7 August 2017

Xiao-dong Pan

2

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Europe PubMed Central

PubMed publication ID

7 August 2017

Jing Zhang

3

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Hui Shen

4

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Nicole C Collins

5

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Arron M Cole

6

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Kevin P Koster

7

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Manel Ben Aissa

8

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Xiao-man Dai

9

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Meng Zhou

10

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Leon M Tai

11

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Yuan-gui Zhu

12

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Mary LaDu

13

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Xiao-chun Chen

14

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Europe PubMed Central

PubMed publication ID

7 August 2017

publication date

5 March 2015

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Europe PubMed Central

PubMed publication ID

7 August 2017

Molecular Neurodegeneration

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Europe PubMed Central

PubMed publication ID

7 August 2017

10

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Europe PubMed Central

PubMed publication ID

7 August 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.

1 reference

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The binding of apolipoprotein E to oligomers and fibrils of amyloid-β alters the kinetics of amyloid aggregation

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Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease

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Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice.

1 reference

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Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition.

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Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease

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Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

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Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer's disease patients and controls

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Sex modifies the APOE-related risk of developing Alzheimer disease

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ApoE and Aβ in Alzheimer's disease: accidental encounters or partners?

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Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk

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APOE modulates the effect of estrogen therapy on Aβ accumulation EFAD-Tg mice

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ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro

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Tripchlorolide improves age-associated cognitive deficits by reversing hippocampal synaptic plasticity impairment and NMDA receptor dysfunction in SAMP8 mice

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Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease.

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Proteolytic cleavage of apolipoprotein E4 as the keystone for the heightened risk associated with Alzheimer's disease

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27 July 2018

Isoform-specific effects of apoE on neurite outgrowth in olfactory epithelium culture

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Role of CREB signaling in aging brain

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ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

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Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex

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Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples

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Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms.

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A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice

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Diosgenin is an exogenous activator of 1,25D₃-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice

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27 July 2018

Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease

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Synaptic changes in Alzheimer's disease and its models

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Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine--searching for the connections

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Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β

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27 July 2018

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.

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Roles of brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) signalling in Alzheimer's disease.

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A multifaceted role for apoE in the clearance of beta-amyloid across the blood-brain barrier

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Apolipoprotein E3 (ApoE3) but not ApoE4 protects against synaptic loss through increased expression of protein kinase C epsilon

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27 July 2018

APOE genotype alters glial activation and loss of synaptic markers in mice

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Brain-derived neurotrophic factor uses CREB and Egr3 to regulate NMDA receptor levels in cortical neurons

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27 July 2018

Introducing Human APOE into Aβ Transgenic Mouse Models

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Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice

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Resolving controversies on the path to Alzheimer's therapeutics

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Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons

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The role of CREB signaling in Alzheimer's disease and other cognitive disorders.

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The effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer's disease

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Selective Vulnerability of Neurons in Layer II of the Entorhinal Cortex during Aging and Alzheimer's Disease

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Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations

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Icariin improves memory impairment in Alzheimer's disease model mice (5xFAD) and attenuates amyloid β‐induced neurite atrophy

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Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice

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Following Activation of the Amyloid Cascade, Apolipoprotein E4 Drives the in vivo Oligomerization of Amyloid-β Resulting in Neurodegeneration

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APOE and cholesterol homeostasis in Alzheimer's disease

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Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking

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ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

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ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.

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Reelin signaling antagonizes beta-amyloid at the synapse

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Bridging physiology and pathology in AD.

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Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

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Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in mice

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APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease

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APOE genotype-specific differences in the innate immune response

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

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Reelin modulates NMDA receptor activity in cortical neurons.

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Apolipoprotein E and cognitive performance

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Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

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Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

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Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

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Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

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Apolipoprotein E alleles as risk factors in Alzheimer's disease

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Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women.

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Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains

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Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease.

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Reduced neuronal signaling in the ageing apolipoprotein-E4 targeted replacement female mice

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Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Reversal of apoE4-driven brain pathology and behavioral deficits by bexarotene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Neuronal clearance of amyloid-β by endocytic receptor LRP1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Hippocampus-related cognitive impairments in young apoE4 targeted replacement mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

The alterations of Ca2+/calmodulin/CaMKII/CaV1.2 signaling in experimental models of Alzheimer's disease and vascular dementia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Loss of activated CaMKII at the synapse underlies Alzheimer's disease memory loss

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Kamikihi-to (KKT) Rescues Axonal and Synaptic Degeneration Associated with Memory Impairment in a Mouse Model of Alzheimer's Disease, 5XFAD

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-β (Aβ) and acts in concert with Aβ to elicit neuronal and behavioral deficits in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

ApoE4‐Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

APOE E4 status predicts age-related cognitive decline in the ninth decade: longitudinal follow-up of the Lothian Birth Cohort 1921.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Review: disruption of the postsynaptic density in Alzheimer's disease and other neurodegenerative dementias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Ginsenoside Rg1 attenuates amyloid-beta content, regulates PKA/CREB activity, and improves cognitive performance in SAMP8 mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Reduced levels of human apoE4 protein in an animal model of cognitive impairment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Cognitive domain decline in healthy apolipoprotein E epsilon4 homozygotes before the diagnosis of mild cognitive impairment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Deficit of NMDA receptor activation in CA1 hippocampal area of aged rats is rescued by D-cycloserine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Impairments in spatial memory retention of GFAP-apoE4 female mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Reelin, lipoprotein receptors and synaptic plasticity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

apoE isoforms and measures of anxiety in probable AD patients and Apoe-/- mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-beta1-42.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

ApoE isoform affects LTP in human targeted replacement mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Disruption of dendritic translation of CaMKIIalpha impairs stabilization of synaptic plasticity and memory consolidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

No loss of synaptic proteins in the hippocampus of aged, behaviorally impaired rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Hippocampal neuron and synaptophysin-positive bouton number in aging C57BL/6 mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Risk of Alzheimer disease with the epsilon4 allele for apolipoprotein E in a population-based study of men aged 62-73 years.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Loss of the Presynaptic Vesicle Protein Synaptophysin in Hippocampus Correlates with Cognitive Decline in Alzheimer Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Apolipoprotein E genotyping in the differential diagnosis, not prediction, of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391134

26 September 2018

Identifiers

10.1186/S13024-015-0002-2

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

ResearchGate publication ID

0 references

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