Reversal of apoE4-driven brain pathology and behavioral deficits by bexarotene. (Q47767946)

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English	Reversal of apoE4-driven brain pathology and behavioral deficits by bexarotene.	scientific article

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scholarly article

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stated in

Europe PubMed Central

PMC publication ID

6608187

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24849361%20AND%20SRC:MED&resulttype=core&format=json

retrieved

18 March 2020

title

Reversal of apoE4-driven brain pathology and behavioral deficits by bexarotene (English)

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stated in

Europe PubMed Central

PMC publication ID

6608187

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24849361%20AND%20SRC:MED&resulttype=core&format=json

retrieved

18 March 2020

main subject

pathology

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author name string

Anat Boehm-Cagan

series ordinal

1

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stated in

Europe PubMed Central

PMC publication ID

6608187

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24849361%20AND%20SRC:MED&resulttype=core&format=json

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18 March 2020

Daniel M Michaelson

series ordinal

2

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Europe PubMed Central

PMC publication ID

6608187

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24849361%20AND%20SRC:MED&resulttype=core&format=json

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18 March 2020

language of work or name

English

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publication date

1 May 2014

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Europe PubMed Central

PMC publication ID

6608187

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24849361%20AND%20SRC:MED&resulttype=core&format=json

retrieved

18 March 2020

published in

Journal of Neuroscience

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stated in

Europe PubMed Central

PMC publication ID

6608187

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24849361%20AND%20SRC:MED&resulttype=core&format=json

retrieved

18 March 2020

volume

34

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stated in

Europe PubMed Central

PMC publication ID

6608187

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24849361%20AND%20SRC:MED&resulttype=core&format=json

retrieved

18 March 2020

issue

21

1 reference

stated in

Europe PubMed Central

PMC publication ID

6608187

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24849361%20AND%20SRC:MED&resulttype=core&format=json

retrieved

18 March 2020

page(s)

7293-7301

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Europe PubMed Central

PMC publication ID

6608187

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24849361%20AND%20SRC:MED&resulttype=core&format=json

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18 March 2020

cites work

Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/24849361

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

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12 December 2020

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A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

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inferred from PubMed ID database lookup

Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

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12 December 2020

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inferred from PubMed ID database lookup

Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: the cholesterol connection

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E and β‐amyloid (1–42) regulation of glycogen synthase kinase‐3β

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of ABCG1, but not ABCA1, correlates with cholesterol release by cerebellar astroglia

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Environmental enrichment stimulates neurogenesis in apolipoprotein E3 and neuronal apoptosis in apolipoprotein E4 transgenic mice

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

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12 December 2020

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inferred from PubMed ID database lookup

Apolipoprotein receptor 2 and X11 alpha/beta mediate apolipoprotein E-induced endocytosis of amyloid-beta precursor protein and beta-secretase, leading to amyloid-beta production

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

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12 December 2020

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inferred from PubMed ID database lookup

Role of ATP-binding cassette transporters in brain lipid transport and neurological disease

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/24849361

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12 December 2020

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inferred from PubMed ID database lookup

Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/24849361

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12 December 2020

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inferred from PubMed ID database lookup

ApoE promotes the proteolytic degradation of Abeta

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

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12 December 2020

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inferred from PubMed ID database lookup

ApoE4-dependent Abeta-mediated neurodegeneration is associated with inflammatory activation in the hippocampus but not the septum

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rexinoid bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR/LXR heterodimer in the liver

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation and function of apolipoprotein E-containing lipoproteins in the nervous system

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/24849361

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ApoE4‐Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The isoform-specific pathological effects of apoE4 in vivo are prevented by a fish oil (DHA) diet and are modified by cholesterol

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

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12 December 2020

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inferred from PubMed ID database lookup

The effects of apolipoproteins E3 and E4 on the transforming growth factor-β system in targeted replacement mice

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of the retinoid X receptor facilitates beta-amyloid clearance across the blood-brain barrier

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampus-related cognitive impairments in young apoE4 targeted replacement mice

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E alleles as risk factors in Alzheimer's disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24849361

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1523/JNEUROSCI.5198-13.2014

1 reference

stated in

Europe PubMed Central

PMC publication ID

6608187

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24849361%20AND%20SRC:MED&resulttype=core&format=json

retrieved

18 March 2020

PMC publication ID

6608187

1 reference

stated in

Europe PubMed Central

PMC publication ID

6608187

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24849361%20AND%20SRC:MED&resulttype=core&format=json

retrieved

18 March 2020

PubMed publication ID

24849361

1 reference

stated in

Europe PubMed Central

PMC publication ID

6608187

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24849361%20AND%20SRC:MED&resulttype=core&format=json

retrieved

18 March 2020

 

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