Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. (Q48404445)

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scientific article published in October 2006

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English	Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.	scientific article published in October 2006

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scholarly article

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Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/17021169

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation (English)

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11 May 2020

Alzheimer's disease

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neurodegeneration

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John F. Disterhoft

9

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11 May 2020

Linda J Van Eldik

10

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Linda Van Eldik

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11 May 2020

author name string

Holly Oakley

1

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11 May 2020

Sarah L Cole

2

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11 May 2020

Sreemathi Logan

3

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11 May 2020

Erika Maus

4

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11 May 2020

Pei Shao

5

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11 May 2020

Jeffery Craft

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11 May 2020

Angela Guillozet-Bongaarts

7

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11 May 2020

Masuo Ohno

8

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11 May 2020

Robert Berry

11

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11 May 2020

Robert Vassar

12

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11 May 2020

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publication date

1 October 2006

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11 February 2018

http://europepmc.org/abstract/MED/17021169

Journal of Neuroscience

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11 May 2020

26

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11 May 2020

40

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11 May 2020

10129-10140

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11 May 2020

Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Function and dysfunction of the presenilins

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetics of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneuronal Abeta42 accumulation in human brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-expression of multiple transgenes in mouse CNS: a comparison of strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A portrait of Alzheimer secretases--new features and familiar faces

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Learning and memory in transgenic mice modeling Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular A-beta amyloid, a sign for worse things to come?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneuronal Abeta42 accumulation in Down syndrome brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E, amyloid, and Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5 deregulation in the pathogenesis of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-peptide: the inside story

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic models of Alzheimer's disease: learning from animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dynamic relationship between intracellular and extracellular pools of Abeta

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibodies to non-beta regions of the beta-amyloid precursor protein detect a subset of senile plaques

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome).

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43)

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of synapsin I and synaptophysin in body fluids by two-site enzyme-linked immunosorbent assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of A beta 42 in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17021169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1202-06.2006

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674618&resulttype=core&format=json

11 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674618&resulttype=core&format=json

11 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674618&resulttype=core&format=json

11 May 2020

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