Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations (Q42651770)

4 November 2017

Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations (English)

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4 November 2017

Katherine Lynn Youmans

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4 November 2017

Steffi Leung

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4 November 2017

Juan Zhang

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4 November 2017

Erika Maus

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4 November 2017

Kathleen Baysac

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4 November 2017

Guojun Bu

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4 November 2017

Robert Vassar

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4 November 2017

Chunjiang Yu

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4 November 2017

Mary Jo LaDu

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4 November 2017

8 January 2011

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Journal of Neuroscience Methods

4 November 2017

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4 November 2017

196

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4 November 2017

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4 November 2017

51-59

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describes a project that uses

4 November 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3049315/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Endocytic pathways mediating oligomeric Abeta42 neurotoxicity.

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Proposed mechanism for lipoprotein remodelling in the brain.

27 May 2018

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Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease

27 May 2018

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Accumulation of intraneuronal Abeta correlates with ApoE4 genotype

27 May 2018

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Amyloid load in nondemented brains correlates with APOE e4.

27 May 2018

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Size-dependent neurotoxicity of beta-amyloid oligomers.

27 May 2018

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27 May 2018

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GFAP reactivity, apolipoprotein E redistribution and cholesterol reduction in human astrocytes treated with alpha-synuclein

27 May 2018

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Reelin signaling antagonizes beta-amyloid at the synapse

27 May 2018

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The role of apolipoprotein E in Alzheimer's disease

27 May 2018

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Isoform-specific proteolysis of apolipoprotein-E in the brain

27 May 2018

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Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice

27 May 2018

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Parenchymal and vascular Abeta-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease.

27 May 2018

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Amyloid beta-peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimer's brain

27 May 2018

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Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits

27 May 2018

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ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo.

27 May 2018

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Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.

27 May 2018

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Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

27 May 2018

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Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms

27 May 2018

1 reference

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Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

27 May 2018

1 reference

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Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis

27 May 2018

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Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformation

27 May 2018

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A specific amyloid-beta protein assembly in the brain impairs memory

27 May 2018

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The development of amyloid beta protein deposits in the aged brain.

27 May 2018

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Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease

27 May 2018

1 reference

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

27 May 2018

1 reference

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CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV

27 May 2018

1 reference

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Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

27 May 2018

1 reference

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Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

27 May 2018

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Effect of apolipoprotein E allele epsilon4 on the initial phase of amyloid beta-protein accumulation in the human brain

27 May 2018

1 reference

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Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

27 May 2018

1 reference

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The amyloid precursor protein of Alzheimer's disease is released by human platelets.

27 May 2018

1 reference

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The predominant form of the amyloid beta-protein precursor in human brain is protease nexin 2.

27 May 2018

1 reference

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Purification and tissue level of the beta-amyloid peptide precursor of rat brain

27 May 2018

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A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.

27 May 2018

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Reduced levels of human apoE4 protein in an animal model of cognitive impairment

16 August 2018

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Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.

16 August 2018

1 reference

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Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049315

Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049315

Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049315

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049315

The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049315

Premorbid effects of APOE on synaptic proteins in human temporal neocortex

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049315

Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049315

Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049315

Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049315

Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049315

Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease.

16 August 2018

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Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049315

Conversion of brain apolipoprotein E to an insoluble form in a mouse model of Alzheimer disease

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049315

Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049315

Is Alzheimer's disease an apolipoprotein E amyloidosis?

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049315

Quantitation of apolipoprotein E

16 August 2018

1 reference

12 December 2020

Differential Level of Platelet Amyloid beta Precursor Protein Isoforms: An Early Marker for Alzheimer Disease

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12 December 2020

Workshop on apolipoprotein quantification

1 reference

12 December 2020

Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis

1 reference

12 December 2020

10.1016/J.JNEUMETH.2010.12.025

Identifiers

DOI

1 reference

4 November 2017

1 reference

4 November 2017

PubMed publication ID

21219931

1 reference