CXCL9

Hemokin (C-X-C motiv) ligand 9
Hemokin (C-X-C motiv) ligand 9
Identifikatori
Simboli	CXCL9; CMK; Humig; MIG; SCYB9; crg-10
Vanjski ID	OMIM: 601704 MGI: 1352449 HomoloGene: 1813 GeneCards: CXCL9 Gene
Ontologija gena
Molekularna funkcija	• aktivnost hemokina;
Celularna komponenta	• ekstracelularni region; • ekstracelularni prostor;
Biološki proces	• hemotaksa; • inflamatorni respons; • imunski respons; • ćelijski odbrambeni respons; • prenos signala; • signalni put, G-protein spregnuti receptor protein; • interćelijska signalizacija;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	4283
Ensembl	ENSG00000138755
UniProt	Q07325
RefSeq (mRNA)	NM_002416
RefSeq (protein)	NP_002407
Lokacija (UCSC)	Chr 4:; 77.14 - 77.15 Mb
PubMed pretraga	[1]

CXCL9, hemokine (C-X-C motif) ligand 9, je mali citokin iz CXC hemokin familije. On je takođe poznat kao monokin indukovan gama interferonom (MIG). CXCL9 je T-ćelijski hemoatraktant. On je blisko srodan sa dva druga CXC hemokina: CXCL10 i CXCL11, čiji geni su locirani u blizini CXCL9 gena na ljudskom hromozomu 4.^[1]^[2] CXCL9, CXCL10 i CXCL11 invršavaju svoje hemotaksne funkcije putem interakcija sa hemokin receptorom CXCR3.^[3]^[4]

Interakcije

Za CXCL9 je bilo pokazano da ostvaruje interakcije sa CXCR3.^[5]^[6]

Reference

^ Lee HH, Farber JM (1996). „Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster"”. Cytogenet. Cell Genet. 74 (4): 255—8. PMID 8976378. doi:10.1159/000134428.
^ O'Donovan N, Galvin M, Morgan JG (1999). „Physical mapping of the CXC chemokine locus on human chromosome 4”. Cytogenet. Cell Genet. 84 (1-2): 39—42. PMID 10343098. doi:10.1159/000015209.
^ Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R (1999). „Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)”. J. Invest. Dermatol. 112 (5): 716—22. PMID 10233762. doi:10.1046/j.1523-1747.1999.00581.x.
^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
^ Lasagni, Laura; Francalanci Michela (2003). „An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4”. J. Exp. Med. United States. 197 (11): 1537—49. ISSN 0022-1007. PMC 2193908 . PMID 12782716. doi:10.1084/jem.20021897.
^ Weng, Y; Siciliano S J (1998). „Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors”. J. Biol. Chem. UNITED STATES. 273 (29): 18288—91. ISSN 0021-9258. PMID 9660793. doi:10.1074/jbc.273.29.18288.

Literatura

Dodatna literatura

Farber JM (1990). „A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines.”. Proc. Natl. Acad. Sci. U.S.A. 87 (14): 5238—42. PMC 54298 . PMID 2115167. doi:10.1073/pnas.87.14.5238.
Liao F; Rabin RL; Yannelli JR (1995). „Human Mig chemokine: biochemical and functional characterization.”. J. Exp. Med. 182 (5): 1301—14. PMC 2192190 . PMID 7595201. doi:10.1084/jem.182.5.1301.
Farber JM (1993). „HuMig: a new human member of the chemokine family of cytokines.”. Biochem. Biophys. Res. Commun. 192 (1): 223—30. PMID 8476424. doi:10.1006/bbrc.1993.1403.
Lee HH, Farber JM (1997). „Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster".”. Cytogenet. Cell Genet. 74 (4): 255—8. PMID 8976378. doi:10.1159/000134428.
Weng Y; Siciliano SJ; Waldburger KE (1998). „Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.”. J. Biol. Chem. 273 (29): 18288—91. PMID 9660793. doi:10.1074/jbc.273.29.18288.
Erdel M; Laich A; Utermann G (1998). „The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10).”. Cytogenet. Cell Genet. 81 (3-4): 271—2. PMID 9730616. doi:10.1159/000015043.
Jenh CH; Cox MA; Kaminski H (1999). „Cutting edge: species specificity of the CC chemokine 6Ckine signaling through the CXC chemokine receptor CXCR3: human 6Ckine is not a ligand for the human or mouse CXCR3 receptors.”. J. Immunol. 162 (7): 3765—9. PMID 10201891.
Rabin RL; Park MK; Liao F (1999). „Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling.”. J. Immunol. 162 (7): 3840—50. PMID 10201901.
Tensen CP; Flier J; Van Der Raaij-Helmer EM (1999). „Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3).”. J. Invest. Dermatol. 112 (5): 716—22. PMID 10233762. doi:10.1046/j.1523-1747.1999.00581.x.
Shields PL; Morland CM; Salmon M (1999). „Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver.”. J. Immunol. 163 (11): 6236—43. PMID 10570316.
Jinquan T; Jing C; Jacobi HH (2000). „CXCR3 expression and activation of eosinophils: role of IFN-gamma-inducible protein-10 and monokine induced by IFN-gamma.”. J. Immunol. 165 (3): 1548—56. PMID 10903763.
Loetscher P; Pellegrino A; Gong JH (2001). „The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3.”. J. Biol. Chem. 276 (5): 2986—91. PMID 11110785. doi:10.1074/jbc.M005652200.
Romagnani P; Annunziato F; Lazzeri E (2001). „Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) alphabeta+ CD8+ single-positive T cells, TCRgammadelta+ T cells, and natural killer-type cells in human thymus.”. Blood. 97 (3): 601—7. PMID 11157474.
Dwinell MB, Lügering N, Eckmann L, Kagnoff MF (2001). „Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells.”. Gastroenterology. 120 (1): 49—59. PMID 11208713. doi:10.1053/gast.2001.20914.
Lambeir AM; Proost P; Durinx C (2001). „Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family.”. J. Biol. Chem. 276 (32): 29839—45. PMID 11390394. doi:10.1074/jbc.M103106200.
Stoof TJ; Flier J; Sampat S (2001). „The antipsoriatic drug dimethylfumarate strongly suppresses chemokine production in human keratinocytes and peripheral blood mononuclear cells.”. Br. J. Dermatol. 144 (6): 1114—20. PMID 11422029. doi:10.1046/j.1365-2133.2001.04220.x.
Campbell JD; Stinson MJ; Simons FE (2001). „In vivo stability of human chemokine and chemokine receptor expression.”. Hum. Immunol. 62 (7): 668—78. PMID 11423172. doi:10.1016/S0198-8859(01)00260-9.
Scapini P; Laudanna C; Pinardi C (2001). „Neutrophils produce biologically active macrophage inflammatory protein-3alpha (MIP-3alpha)/CCL20 and MIP-3beta/CCL19.”. Eur. J. Immunol. 31 (7): 1981—8. PMID 11449350. doi:10.1002/1521-4141(200107)31:7<1981::AID-IMMU1981>3.0.CO;2-X.
Gillitzer R (2001). „Inflammation in human skin: a model to study chemokine-mediated leukocyte migration in vivo.”. J. Pathol. 194 (4): 393—4. PMID 11523044. doi:10.1002/1096-9896(200108)194:4<393::AID-PATH907>3.0.CO;2-7.
Romagnani P; Rotondi M; Lazzeri E (2002). „Expression of IP-10/CXCL10 and MIG/CXCL9 in the thyroid and increased levels of IP-10/CXCL10 in the serum of patients with recent-onset Graves' disease.”. Am. J. Pathol. 161 (1): 195—206. PMC 1850693 . PMID 12107104.

[pmid8976378-1] Lee HH, Farber JM (1996). „Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster"”. Cytogenet. Cell Genet. 74 (4): 255—8. PMID 8976378. doi:10.1159/000134428.

[pmid10343098-2] O'Donovan N, Galvin M, Morgan JG (1999). „Physical mapping of the CXC chemokine locus on human chromosome 4”. Cytogenet. Cell Genet. 84 (1-2): 39—42. PMID 10343098. doi:10.1159/000015209.

[pmid10233762-3] Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R (1999). „Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)”. J. Invest. Dermatol. 112 (5): 716—22. PMID 10233762. doi:10.1046/j.1523-1747.1999.00581.x.

[4] Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

[pmid12782716-5] Lasagni, Laura; Francalanci Michela (2003). „An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4”. J. Exp. Med. United States. 197 (11): 1537—49. ISSN 0022-1007. PMC 2193908 . PMID 12782716. doi:10.1084/jem.20021897.

[pmid9660793-6] Weng, Y; Siciliano S J (1998). „Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors”. J. Biol. Chem. UNITED STATES. 273 (29): 18288—91. ISSN 0021-9258. PMID 9660793. doi:10.1074/jbc.273.29.18288.

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