Oksaflozan

Oksaflozan
(IUPAC) ime
	4-propan-2-il-2-[3-(trifluorometil)fenil]morfolin
Klinički podaci
Identifikatori
CAS broj	26629-86-7
ATC kod	N06AX10
PubChem	432824
ChemSpider	382782
UNII	V4WLW77V5Q
KEGG	D07340
Hemijski podaci
Formula	C14H18F3NO
Mol. masa	273,29 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C14H18F3NO/c1-10(2)18-6-7-19-13(9-18)11-4-3-5-12(8-11)14(15,16)17/h3-5,8,10,13H,6-7,9H2,1-2H3 ; Key: FVYUQFQCEOZYHZ-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	℞ Prescription only
Način primene	Oralno

Oksaflozan (Confliktan) je antidepresiv i anksiolitik koji je uveden u prodaju 1982. za tretmant depresije, ali je u međuvremenu izašao iz upotrebe.^[5]^[6] On je prolek za N-dealkiloksaflozan, koji deluje kao neselektivni agonist serotoninskih receptora: 5-HT_1A (pKi = 7,1), 5-HT_2A (pKi = 6,0), i 5-HT_2C (pKi = 7,5).^[7] Oksaflozan potencijalno ima i antiholinergičko dejstvo pri visokim dozama.^[8]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. str. 766. ISBN 3-88763-075-0.
↑ Sittig, Marshall (1988). Pharmaceutical manufacturing encyclopedia. Park Ridge, N.J., U.S.A: Noyes Publications. str. 1122. ISBN 0-8155-1144-2.
↑ Leysen DC (February 1999). „Selective 5-HT2C agonists as potential antidepressants”. IDrugs : the Investigational Drugs Journal 2 (2): 109–20. PMID 16160946.
↑ Dutertre JP, Barbier P, Suc AL, Jonville AP, Autret E (1992). „Oxaflozane overdose in a child”. Journal of Toxicology. Clinical Toxicology 30 (1): 123–6. PMID 1542141.

Literatura

Sittig, Marshall (1988). Pharmaceutical manufacturing encyclopedia. Park Ridge, N.J., U.S.A: Noyes Publications. str. 1122. ISBN 0-8155-1144-2.
Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. str. 766. ISBN 3-88763-075-0.
Rascol A, Maurel H, David J, Layani M (1974). „[Preliminary clinical results of a new non tricyclic antidepressive drug: oxaflozane]” (French). Thérapie 29 (1): 95–9. PMID 4603757.
Hache J, Duchene-Marullaz P, Streichenberger G (1974). „[Pharmacological profile of a new non tricyclic antidepressant: oxaflozane (1,766 Cerm)]” (French). Thérapie 29 (1): 81–93. PMID 4849381.
Constantin M, Pognat JF (1979). „Comparative study of oxaflozane urinary metabolism in man, the dog and the rat. Identification of the principal metabolites”. Arzneimittel-Forschung 29 (1): 109–14. PMID 582104.
Bertolino A, palermo M, Porro V (1985). „Oxaflozane, a new nontricyclic antidepressant in the treatment of anxiety-depressions syndromes.”. Acta Ther (11): 209–218.
Aguglia E (1986). „On the therapetic value of axaflozane: Its application in the treatment of emotional disturbances of the anxious-depressive type accompanied by somatic manifestations.”. Acta Ther (12): 259–267.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[isbn3-88763-075-0-5] Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. str. 766. ISBN 3-88763-075-0.

[isbn0-8155-1144-2-6] Sittig, Marshall (1988). Pharmaceutical manufacturing encyclopedia. Park Ridge, N.J., U.S.A: Noyes Publications. str. 1122. ISBN 0-8155-1144-2.

[pmid16160946-7] Leysen DC (February 1999). „Selective 5-HT2C agonists as potential antidepressants”. IDrugs : the Investigational Drugs Journal 2 (2): 109–20. PMID 16160946.

[pmid1542141-8] Dutertre JP, Barbier P, Suc AL, Jonville AP, Autret E (1992). „Oxaflozane overdose in a child”. Journal of Toxicology. Clinical Toxicology 30 (1): 123–6. PMID 1542141.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]