GPR4
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| G protein-spregnuti receptor 4 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | GPR4; | ||||||||||
| Vanjski ID | OMIM: 600551 MGI: 2441992 HomoloGene: 3867 IUPHAR: GPR4 GeneCards: GPR4 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 2828 | 319197 | |||||||||
| Ensembl | ENSG00000177464 | ENSMUSG00000044317 | |||||||||
| UniProt | P46093 | n/a | |||||||||
| RefSeq (mRNA) | NM_005282 | NM_175668 | |||||||||
| RefSeq (protein) | NP_005273 | NP_783599 | |||||||||
| Lokacija (UCSC) | Chr 19: 50.78 - 50.8 Mb | Chr 7: 18.37 - 18.38 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
GPR4, G-protein spregnuti receptor 4, je protein koji je kod čoveka kodiran GPR4 genom.[1][2]
- ↑ Mahadevan MS, Baird S, Bailly JE, Shutler GG, Sabourin LA, Tsilfidis C, Neville CE, Narang M, Korneluk RG (Apr 1996). „Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13.3”. Genomics 30 (1): 84–8. DOI:10.1006/geno.1995.0013. PMID 8595909.
- ↑ „Entrez Gene: GPR4 G protein-coupled receptor 4”.
- An S, Tsai C, Goetzl EJ (1996). „Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue.”. FEBS Lett. 375 (1-2): 121–4. DOI:10.1016/0014-5793(95)01196-L. PMID 7498459.
- Heiber M, Docherty JM, Shah G, et al. (1995). „Isolation of three novel human genes encoding G protein-coupled receptors.”. DNA Cell Biol. 14 (1): 25–35. DOI:10.1089/dna.1995.14.25. PMID 7832990.
- Zhu K, Baudhuin LM, Hong G, et al. (2001). „Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4.”. J. Biol. Chem. 276 (44): 41325–35. DOI:10.1074/jbc.M008057200. PMID 11535583.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lum H, Qiao J, Walter RJ, et al. (2003). „Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells.”. Am. J. Physiol. Heart Circ. Physiol. 285 (4): H1786–9. DOI:10.1152/ajpheart.00359.2003. PMID 12805023.
- Ludwig MG, Vanek M, Guerini D, et al. (2003). „Proton-sensing G-protein-coupled receptors.”. Nature 425 (6953): 93–8. DOI:10.1038/nature01905. PMID 12955148.
- Bektas M, Barak LS, Jolly PS, et al. (2003). „The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner.”. Biochemistry 42 (42): 12181–91. DOI:10.1021/bi035051y. PMID 14567679.
- Sin WC, Zhang Y, Zhong W, et al. (2004). „G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers.”. Oncogene 23 (37): 6299–303. DOI:10.1038/sj.onc.1207838. PMID 15221007.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kim KS, Ren J, Jiang Y, et al. (2005). „GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine.”. FASEB J. 19 (7): 819–21. DOI:10.1096/fj.04-2988fje. PMID 15857892.
- Qiao J, Huang F, Naikawadi RP, et al. (2006). „Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4.”. Am. J. Physiol. Lung Cell Mol. Physiol. 291 (1): L91–101. DOI:10.1152/ajplung.00508.2005. PMID 16461426.
- Huang F, Mehta D, Predescu S, et al. (2007). „A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration.”. Endothelium 14 (1): 25–34. DOI:10.1080/10623320601177288. PMID 17364894.
- Zou Y, Kim CH, Chung JH, et al. (2007). „Upregulation of endothelial adhesion molecules by lysophosphatidylcholine. Involvement of G protein-coupled receptor GPR4.”. FEBS J. 274 (10): 2573–84. DOI:10.1111/j.1742-4658.2007.05792.x. PMID 17437524.
- Tobo M, Tomura H, Mogi C, et al. (2007). „Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms.”. Cell. Signal. 19 (8): 1745–53. DOI:10.1016/j.cellsig.2007.03.009. PMID 17462861.