LEP

LEP
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AX8
Dynodwyr
Cyfenwau	LEP, LEPD, OB, OBS, leptin
Dynodwyr allanol	OMIM: 164160 HomoloGene: 193 GeneCards: LEP
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • hormone activity • peptide hormone receptor binding • signaling receptor binding Cydrannau o'r gell • cytoplasm • extracellular region • extracellular space Prosesau biolegol • regulation of protein phosphorylation • response to dietary excess • cellular response to retinoic acid • positive regulation of developmental growth • negative regulation of glucagon secretion • placenta development • cardiac muscle hypertrophy • regulation of angiogenesis • prostaglandin secretion • regulation of intestinal cholesterol absorption • T cell differentiation • positive regulation of reactive oxygen species metabolic process • central nervous system neuron development • Rhythm circadaidd • positive regulation of ion transport • angiogenesis • glucose metabolic process • positive regulation of peroxisome proliferator activated receptor signaling pathway • positive regulation of hepatic stellate cell activation • regulation of endothelial cell proliferation • intestinal absorption • response to ethanol • negative regulation of autophagy • positive regulation of p38MAPK cascade • positive regulation of protein kinase B signaling • negative regulation of metabolic process • negative regulation of vasoconstriction • glucose homeostasis • regulation of insulin secretion • regulation of steroid biosynthetic process • insulin secretion • regulation of natural killer cell activation • regulation of fat cell differentiation • response to vitamin E • response to nutrient levels • bone mineralization involved in bone maturation • positive regulation of T cell proliferation • positive regulation of protein import into nucleus • regulation of brown fat cell differentiation • fatty acid beta-oxidation • regulation of metabolic process • hormone metabolic process • positive regulation of MAPK cascade • positive regulation of TOR signaling • cellular response to L-ascorbic acid • ovulation from ovarian follicle • activation of protein kinase C activity • atgynhyrchu rhywiol • negative regulation of cartilage development • response to nutrient • negative regulation of glutamine transport • leptin-mediated signaling pathway • bile acid metabolic process • female pregnancy • negative regulation of apoptotic process • cholesterol metabolic process • positive regulation of follicle-stimulating hormone secretion • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of appetite • regulation of protein localization to nucleus • regulation of blood pressure • negative regulation of glucose import • leukocyte tethering or rolling • negative regulation of lipid storage • adipose tissue development • GO:1903106 positive regulation of insulin receptor signaling pathway • bone growth • positive regulation of receptor signaling pathway via JAK-STAT • glycerol biosynthetic process • positive regulation of luteinizing hormone secretion • fatty acid catabolic process • regulation of gluconeogenesis • response to estradiol • GO:0007243 intracellular signal transduction • adult feeding behavior • response to hypoxia • regulation of natural killer cell proliferation • eating behavior • GO:0032737 positive regulation of cytokine production • regulation of cytokine production involved in inflammatory response • regulation of nitric-oxide synthase activity • response to activity • cellular response to leptin stimulus • regulation of cell cycle • regulation of natural killer cell mediated cytotoxicity • positive regulation of fat cell apoptotic process • positive regulation of cell population proliferation • regulation of lipoprotein lipid oxidation • positive regulation of phosphatidylinositol 3-kinase signaling • GO:0072468 signal transduction • regulation of bone remodeling • lipid metabolism • negative regulation of appetite by leptin-mediated signaling pathway • interleukin-12 production • positive regulation of tumor necrosis factor production • interleukin-6 production • response to insulin • tyrosine phosphorylation of STAT protein • ffagocytosis • energy reserve metabolic process • positive regulation of tyrosine phosphorylation of STAT protein • regulation of signaling receptor activity • determination of adult lifespan • regulation of lipid biosynthetic process • positive regulation of cold-induced thermogenesis • aorta development • GO:0048552 regulation of catalytic activity • elastin metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3952	n/a
Ensembl	ENSG00000174697	n/a
UniProt	P41159	n/a
RefSeq (mRNA)	NM_000230	n/a
RefSeq (protein)	NP_000221	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LEP yw LEP a elwir hefyd yn Leptin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7q32.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LEP.

• OB
• OBS
• LEPD

• "Leptin and autoimmune disease. ". Nihon Rinsho Meneki Gakkai Kaishi. 2017. PMID 28747601.
• "Physical fitness and plasma leptin in women with recent gestational diabetes. ". PLoS One. 2017. PMID 28609470.
• "Concordance of bioactive vs. total immunoreactive serum leptin levels in children with severe early onset obesity. ". PLoS One. 2017. PMID 28542631.
• "High-fat diet induced leptin and Wnt expression: RNA-sequencing and pathway analysis of mouse colonic tissue and tumors. ". Carcinogenesis. 2017. PMID 28426873.
• "Associations of LEP, CRH, ICAM-1, and LINE-1 methylation, measured in saliva, with waist circumference, body mass index, and percent body fat in mid-childhood.". Clin Epigenetics. 2017. PMID 28360946.