Development of matrix metalloproteinase-13 inhibitors - A structure-activity/structure-property relationship study (Q91698757)

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24 April 2020

title

Development of matrix metalloproteinase-13 inhibitors - A structure-activity/structure-property relationship study (English)

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24 April 2020

Gregg B Fields

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24 April 2020

Rita Fuerst

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24 April 2020

Jun Yong Choi

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24 April 2020

Anna M Knapinska

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24 April 2020

Lyndsay Smith

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24 April 2020

Michael D Cameron

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24 April 2020

Claudia Ruiz

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24 April 2020

William R Roush

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24 April 2020

publication date

20 August 2018

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Bioorganic & Medicinal Chemistry

24 April 2020

published in

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24 April 2020

volume

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24 April 2020

issue

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24 April 2020

page(s)

4984-4995

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Recent Research Advances in Selective Matrix Metalloproteinase-13 Inhibitors as Anti-Osteoarthritis Agents

24 April 2020

cites work

1 reference

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Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors.

23 February 2021

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Matrix metalloproteinase collagenolysis in health and disease

23 February 2021

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Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach.

23 February 2021

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Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors

23 February 2021

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Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential

23 February 2021

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Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.

23 February 2021

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Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site

23 February 2021

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A current review of molecular mechanisms regarding osteoarthritis and pain

23 February 2021

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Interstitial collagen catabolism

23 February 2021

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The Global Economic Cost of Osteoarthritis: How the UK Compares

23 February 2021

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Discovery and evaluation of a non-Zn chelating, selective matrix metalloproteinase 13 (MMP-13) inhibitor for potential intra-articular treatment of osteoarthritis

23 February 2021

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Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds.

23 February 2021

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Osteoarthritis: an update with relevance for clinical practice

23 February 2021

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The role of acetaminophen in the treatment of osteoarthritis

23 February 2021

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Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors

23 February 2021

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Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation

23 February 2021

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High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate

23 February 2021

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Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening

23 February 2021

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Joint diseases and matrix metalloproteinases: a role for MMP-13.

23 February 2021

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Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

23 February 2021

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Characterization of an exosite binding inhibitor of matrix metalloproteinase 13.

23 February 2021

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MMPs as therapeutic targets--still a viable option?

23 February 2021

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Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects

23 February 2021

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23 February 2021

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Potent, selective pyrimidinetrione-based inhibitors of MMP-13

23 February 2021

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Osteoarthritis: pathobiology-targets and ways for therapeutic intervention

23 February 2021

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23 February 2021

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23 February 2021

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23 February 2021

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23 February 2021

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23 February 2021

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Triple-helical peptide analysis of collagenolytic protease activity

23 February 2021

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Matrix metalloproteinases as therapeutic targets in arthritic diseases: bull's-eye or missing the mark?

23 February 2021

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Hepatic disposition of electrophilic acyl glucuronide conjugates.

23 February 2021

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Property-based design: optimization of drug absorption and pharmacokinetics

23 February 2021

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Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice

23 February 2021

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Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

23 February 2021

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Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes

23 February 2021

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Metabolic activation and drug toxicity

23 February 2021

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10.1016/J.BMC.2018.08.020

23 February 2021

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30249495%20AND%20SRC:MED&resulttype=core&format=json

24 April 2020

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24 April 2020

PubMed publication ID

30249495

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