Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors. (Q38430238)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28653849%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

title

Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28653849%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Jun Yong Choi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28653849%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Rita Fuerst

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28653849%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Anna M Knapinska

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28653849%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Alexander B Taylor

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28653849%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Lyndsay Smith

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28653849%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Xiaohang Cao

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28653849%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

P John Hart

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28653849%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

language of work or name

English

0 references

publication date

27 June 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28653849%20AND%20SRC:MED&resulttype=core&format=json

Journal of Medicinal Chemistry

23 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28653849%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28653849%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28653849%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

page(s)

5816-5825

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28653849%20AND%20SRC:MED&resulttype=core&format=json

Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors

23 March 2020

cites work

1 reference

12 December 2020

New drugs on the horizon: matrix metalloproteinase inhibitors

1 reference

12 December 2020

The Protein Data Bank

1 reference

12 December 2020

Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice

1 reference

12 December 2020

Kinetic analysis of matrix metalloproteinase activity using fluorogenic triple-helical substrates

1 reference

12 December 2020

Matrix metalloproteinases as therapeutic targets in arthritic diseases: bull's-eye or missing the mark?

1 reference

12 December 2020

Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro

1 reference

12 December 2020

Triple-helical peptide analysis of collagenolytic protease activity

1 reference

12 December 2020

Acyl glucuronide drug metabolites: toxicological and analytical implications

1 reference

12 December 2020

1 reference

12 December 2020

Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

1 reference

12 December 2020

Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening

1 reference

12 December 2020

Structure-based strategies for drug design and discovery

1 reference

12 December 2020

Characterization of Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2, a fluorogenic substrate with increased specificity constants for collagenases and tumor necrosis factor converting enzyme

1 reference

12 December 2020

Structure-aided drug design's next generation

1 reference

12 December 2020

Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis

1 reference

12 December 2020

Matrix metalloproteinases as modulators of inflammation and innate immunity

1 reference

12 December 2020

Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14.

1 reference

12 December 2020

Identification of potent and selective MMP-13 inhibitors

1 reference

12 December 2020

Matrix metalloproteinases: role in arthritis

1 reference

12 December 2020

Towards third generation matrix metalloproteinase inhibitors for cancer therapy

1 reference

12 December 2020

The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity

1 reference

12 December 2020

Activity of matrix metalloproteinase-9 against native collagen types I and III.

1 reference

12 December 2020

Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects

1 reference

12 December 2020

MMPs as therapeutic targets--still a viable option?

1 reference

12 December 2020

Joint diseases and matrix metalloproteinases: a role for MMP-13.

1 reference

12 December 2020

Stromal Expression of MMP-13 Is Required for Melanoma Invasion and Metastasis

1 reference

12 December 2020

A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models.

1 reference

12 December 2020

Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors

1 reference

12 December 2020

Matrix metalloproteinase inhibitors: a critical appraisal of design principles and proposed therapeutic utility.

1 reference

12 December 2020

Predictability of idiosyncratic drug toxicity risk for carboxylic acid-containing drugs based on the chemical stability of acyl glucuronide

1 reference

12 December 2020

Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis

1 reference

12 December 2020

Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds.

1 reference

12 December 2020

Discovery and evaluation of a non-Zn chelating, selective matrix metalloproteinase 13 (MMP-13) inhibitor for potential intra-articular treatment of osteoarthritis

1 reference

12 December 2020

Interstitial collagen catabolism

1 reference

12 December 2020

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF.

1 reference

12 December 2020

Computational methods in drug discovery

1 reference

12 December 2020

Discovery of novel, highly potent, and selective quinazoline-2-carboxamide-based matrix metalloproteinase (MMP)-13 inhibitors without a zinc binding group using a structure-based design approach

1 reference

12 December 2020

Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.

1 reference

12 December 2020

Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors

1 reference

12 December 2020

Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach.

1 reference

12 December 2020

10.1021/ACS.JMEDCHEM.7B00514

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28653849%20AND%20SRC:MED&resulttype=core&format=json

release_mabgxprdsncdpkbvf2cbqbhmai

23 March 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/mabgxprdsncdpkbvf2cbqbhmai

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28653849%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

PubMed publication ID

28653849

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28653849%20AND%20SRC:MED&resulttype=core&format=json