A current review of molecular mechanisms regarding osteoarthritis and pain (Q27023006)

Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase

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Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production

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Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

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Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model

21 March 2017

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Fibroblast growth factor-2 promotes catabolism via FGFR1-Ras-Raf-MEK1/2-ERK1/2 axis that coordinates with the PKCδ pathway in human articular chondrocytes

21 March 2017

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Species-specific biological effects of FGF-2 in articular cartilage: implication for distinct roles within the FGF receptor family

28 September 2017

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Biological effects of the plant-derived polyphenol resveratrol in human articular cartilage and chondrosarcoma cells

28 September 2017

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The pathophysiologic role of the protein kinase Cδ pathway in the intervertebral discs of rabbits and mice: in vitro, ex vivo, and in vivo studies

28 September 2017

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The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review

28 September 2017

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Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee

28 September 2017

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Lactoferricin mediates anabolic and anti-catabolic effects in the intervertebral disc

28 September 2017

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Update on peripheral mechanisms of pain: beyond prostaglandins and cytokines

28 September 2017

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The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia

28 September 2017

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The role of growth factors in cartilage repair

28 September 2017

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OARSI-FDA initiative: defining the disease state of osteoarthritis

28 September 2017

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Alteration of sensory neurons and spinal response to an experimental osteoarthritis pain model

28 September 2017

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Insurer and out-of-pocket costs of osteoarthritis in the US: evidence from national survey data

28 September 2017

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Does knee malalignment increase the risk of development and progression of knee osteoarthritis? A systematic review

28 September 2017

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Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis

28 September 2017

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Molecular mechanisms of cartilage destruction in osteoarthritis.

28 September 2017

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The action of resveratrol, a phytoestrogen found in grapes, on the intervertebral disc

28 September 2017

1 reference

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The symptoms of osteoarthritis and the genesis of pain

28 September 2017

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Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis

28 September 2017

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A structural framework for understanding the multifunctional character of lactoferrin

28 September 2017

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Basic fibroblast growth factor accelerates matrix degradation via a neuro-endocrine pathway in human adult articular chondrocytes

28 September 2017

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Bovine lactoferricin causes apoptosis in Jurkat T-leukemia cells by sequential permeabilization of the cell membrane and targeting of mitochondria

28 September 2017

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Arthritis and pain. Future targets to control osteoarthritis pain

28 September 2017

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Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes

28 September 2017

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Effects of resveratrol in inflammatory arthritis

28 September 2017

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Classification of osteoarthritis biomarkers: a proposed approach.

28 September 2017

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Gene therapeutic approaches-transfer in vivo

28 September 2017

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Basic fibroblast growth factor inhibits the anabolic activity of insulin-like growth factor 1 and osteogenic protein 1 in adult human articular chondrocytes

28 September 2017

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Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties

28 September 2017

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The sources of pain in knee osteoarthritis

28 September 2017

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Pathogenesis and management of pain in osteoarthritis.

28 September 2017

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The impact of osteoarthritis: implications for research

28 September 2017

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The regulation of chondrocyte function by proinflammatory mediators: prostaglandins and nitric oxide.

28 September 2017

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Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia.

28 September 2017

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The role of reactive oxygen species in homeostasis and degradation of cartilage

28 September 2017

1 reference

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Resveratrol, a natural chemopreventive agent against degenerative diseases.

28 September 2017

1 reference

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Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro.

28 September 2017

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Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief

28 September 2017

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Resveratrol, a natural stilbene in grapes and wine, enhances intraphagocytosis in human promonocytes: a co-factor in antiinflammatory and anticancer chemopreventive activity.

28 September 2017

1 reference

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Biological effects of resveratrol

28 September 2017

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Osteoarthritis associated with mild chondrodysplasia in transgenic mice expressing alpha 1(IX) collagen chains with a central deletion

28 September 2017

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Circadian rhythm of serum interleukin-6 in rheumatoid arthritis

28 September 2017

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Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes

28 September 2017

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Regulation of inflammation signalling by resveratrol in human chondrocytes in vitro

28 September 2017

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Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis

31 May 2018

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PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade

31 May 2018

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Benefits of massive weight loss on symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritis

31 May 2018

1 reference

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Regulation of prostaglandin E(2) synthesis in cells derived from chondrocytes of patients with osteoarthritis

28 November 2018

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Resveratrol suppresses interleukin-1beta-induced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the treatment of osteoarthritis

28 November 2018

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Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade

28 November 2018

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Successful treatment of inflammatory knee osteoarthritis with tumour necrosis factor blockade

28 November 2018

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Effect of resveratrol in experimental osteoarthritis in rabbits

28 November 2018

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Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons

28 November 2018

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Synovial tissue inflammation in early and late osteoarthritis

28 November 2018

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Disc inflammation potentially promotes axonal regeneration of dorsal root ganglion neurons innervating lumbar intervertebral disc in rats

28 November 2018

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Oral administration of lactoferrin inhibits inflammation and nociception in rat adjuvant-induced arthritis

28 November 2018

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Effects of cis-resveratrol on inflammatory murine macrophages: antioxidant activity and down-regulation of inflammatory genes

28 November 2018

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Changes in the effect of spinal prostaglandin E2 during inflammation: prostaglandin E (EP1-EP4) receptors in spinal nociceptive processing of input from the normal or inflamed knee joint.

28 November 2018

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Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat.

28 November 2018

1 reference

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Resveratrol increases serine15-phosphorylated but transcriptionally impaired p53 and induces a reversible DNA replication block in serum-activated vascular smooth muscle cells

28 November 2018

1 reference

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Cyclooxygenase 2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants

28 November 2018

1 reference

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Anti-inflammatory tetramers of resveratrol from the roots of Vitis amurensis and the conformations of the seven-membered ring in some oligostilbenes

28 November 2018

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The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1.

28 November 2018

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Effects of interleukin-1beta and tumor necrosis factor-alpha on expression of matrix-related genes by cultured equine articular chondrocytes

28 November 2018

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12 December 2020

The effects of local administration of lactoferrin on inflammation in murine autoimmune and infectious arthritis

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12 December 2020

Biological effects of resveratrol

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12 December 2020

The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules

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12 December 2020

Epidemiology of osteoarthritis: an update

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12 December 2020

Sensitization of unmyelinated sensory fibers of the joint nerve to mechanical stimuli by interleukin-6 in the rat: an inflammatory mechanism of joint pain

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12 December 2020

Impact of nervous system hyperalgesia on pain, disability, and quality of life in patients with knee osteoarthritis: a controlled analysis

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12 December 2020

The symptoms of osteoarthritis and the genesis of pain

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12 December 2020

Genetic epidemiology of hip and knee osteoarthritis

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12 December 2020

Osteoarthritic tissues modulate functional properties of sensory neurons associated with symptomatic OA pain

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12 December 2020

Modulation by interleukin 1 and tumor necrosis factor alpha of production of collagenase, tissue inhibitor of metalloproteinases and collagen types in differentiated and dedifferentiated articular chondrocytes

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12 December 2020

Growth Factor and Catabolic Cytokine Concentrations Are Influenced by the Cellular Composition of Platelet-Rich Plasma

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12 December 2020

Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression

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12 December 2020

Variability in cytokine and cell adhesion molecule staining in arthroscopic synovial biopsies: quantification using color video image analysis

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12 December 2020

Interleukin (IL)-6 and its soluble receptor induce TIMP-1 expression in synoviocytes and chondrocytes, and block IL-1-induced collagenolytic activity

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12 December 2020