Organotypic brain slice cultures to model neurodegenerative proteinopathies (Q91612343)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31791377%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

review article

2 references

29 April 2021

Organotypic brain slice cultures to model neurodegenerative proteinopathies (English)

1 reference

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23 April 2020

1 reference

29 April 2021

1 reference

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23 April 2020

1 reference

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23 April 2020

H S Futch

1 reference

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23 April 2020

B D Moore

series ordinal

1 reference

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23 April 2020

publication date

2 December 2019

2 references

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23 April 2020

29 April 2021

Molecular Neurodegeneration

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31791377%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

29 April 2021

1 reference

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23 April 2020

issue

1 reference

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23 April 2020

page(s)

1 reference

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Creative Commons Attribution 4.0 International

23 April 2020

1 reference

Long-term adult human brain slice cultures as a model system to study human CNS circuitry and disease

29 April 2021

cites work

1 reference

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Harnessing Immunoproteostasis to Treat Neurodegenerative Disorders

23 February 2021

1 reference

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rAAV-based brain slice culture models of Alzheimer's and Parkinson's disease inclusion pathologies

23 February 2021

1 reference

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Animal models of neurodegenerative diseases

23 February 2021

1 reference

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Preparation of organotypic brain slice cultures for the study of Alzheimer's disease.

23 February 2021

1 reference

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Novel monoclonal antibodies targeting the microtubule-binding domain of human tau.

23 February 2021

1 reference

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A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters

23 February 2021

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Distinct differences in prion-like seeding and aggregation between tau protein variants provide mechanistic insights into tauopathies

23 February 2021

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Inhibition of glycogen synthase kinase-3 by BTA-EG4 reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer's disease

23 February 2021

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α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading

23 February 2021

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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

23 February 2021

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Stem cell models of Alzheimer's disease: progress and challenges

23 February 2021

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TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.

23 February 2021

1 reference

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Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures.

23 February 2021

1 reference

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In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni

23 February 2021

1 reference

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α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

23 February 2021

1 reference

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Rat brain sagittal organotypic slice cultures as an ex vivo dopamine cell loss system

23 February 2021

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Young microglia restore amyloid plaque clearance of aged microglia.

23 February 2021

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A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons

23 February 2021

1 reference

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Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS.

23 February 2021

1 reference

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Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice

23 February 2021

1 reference

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Conversion of Synthetic Aβ to In Vivo Active Seeds and Amyloid Plaque Formation in a Hippocampal Slice Culture Model.

23 February 2021

1 reference

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Optogenetic control of human neurons in organotypic brain cultures

23 February 2021

1 reference

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The amyloid hypothesis of Alzheimer's disease at 25 years

23 February 2021

1 reference

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Microglia in Alzheimer's disease: the good, the bad and the ugly

23 February 2021

1 reference

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Region-specific dendritic simplification induced by Aβ, mediated by tau via dysregulation of microtubule dynamics: a mechanistic distinct event from other neurodegenerative processes

23 February 2021

1 reference

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Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures

23 February 2021

1 reference

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Organotypic brain slice cultures as a model to study angiogenesis of brain vessels

23 February 2021

1 reference

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Organotypic brain slice cultures: A review

23 February 2021

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Organotypic vibrosections from whole brain adult Alzheimer mice (overexpressing amyloid-precursor-protein with the Swedish-Dutch-Iowa mutations) as a model to study clearance of beta-amyloid plaques

23 February 2021

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Invited review: Neuropathology of tauopathies: principles and practice.

23 February 2021

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A long Stokes shift red fluorescent Ca2+ indicator protein for two-photon and ratiometric imaging

23 February 2021

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Astrocytes and neuroinflammation in Alzheimer's disease.

23 February 2021

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Large-scale, high-resolution multielectrode-array recording depicts functional network differences of cortical and hippocampal cultures

23 February 2021

1 reference

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An organotypic brain slice preparation from adult patients with temporal lobe epilepsy

23 February 2021

1 reference

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Platelet-derived nerve growth factor supports the survival of cholinergic neurons in organotypic rat brain slices

23 February 2021

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Identification of a unique TGF-β-dependent molecular and functional signature in microglia

23 February 2021

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Antibody uptake into neurons occurs primarily via clathrin-dependent Fcγ receptor endocytosis and is a prerequisite for acute tau protein clearance.

23 February 2021

1 reference

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Modeling nigrostriatal degeneration in organotypic cultures, a new ex vivo model of Parkinson's disease

23 February 2021

1 reference

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Propagation of tau pathology in Alzheimer's disease: identification of novel therapeutic targets

23 February 2021

1 reference

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Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology

23 February 2021

1 reference

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Differential subcellular targeting of glutamate receptor subtypes during homeostatic synaptic plasticity.

23 February 2021

1 reference

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Ultrasensitive fluorescent proteins for imaging neuronal activity

23 February 2021

1 reference

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Thinking laterally about neurodegenerative proteinopathies

23 February 2021

1 reference

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NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss.

23 February 2021

1 reference

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Reactive astrocytes secrete lcn2 to promote neuron death

23 February 2021

1 reference

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Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors

23 February 2021

1 reference

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β-Amyloid induced effects on cholinergic, serotonergic, and dopaminergic neurons is differentially counteracted by anti-inflammatory drugs

23 February 2021

1 reference

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Tau protein kinases: involvement in Alzheimer's disease

23 February 2021

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dSarm/Sarm1 is required for activation of an injury-induced axon death pathway

23 February 2021

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Tunicamycin produces TDP-43 cytoplasmic inclusions in cultured brain organotypic slices

23 February 2021

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Organotypic vibrosections: novel whole sagittal brain cultures

23 February 2021

1 reference

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Characterization of cortical neuronal and glial alterations during culture of organotypic whole brain slices from neonatal and mature mice

23 February 2021

1 reference

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Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay

23 February 2021

1 reference

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Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

23 February 2021

1 reference

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Evaluation of cell damage in organotypic hippocampal slice culture from adult mouse: a potential model system to study neuroprotection

23 February 2021

1 reference

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Neuron loss in transgenic mouse models of Alzheimer's disease

23 February 2021

1 reference

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Tau in Alzheimer disease and related tauopathies

23 February 2021

1 reference

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Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease.

23 February 2021

1 reference

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The role of caspases in Alzheimer's disease; potential novel therapeutic opportunities

23 February 2021

1 reference

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Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

23 February 2021

1 reference

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Regeneration and characterization of adult mouse hippocampal neurons in a defined in vitro system.

23 February 2021

1 reference

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Brain slices as models for neurodegenerative disease and screening platforms to identify novel therapeutics

23 February 2021

1 reference

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A FLEX switch targets Channelrhodopsin-2 to multiple cell types for imaging and long-range circuit mapping

23 February 2021

1 reference

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The use of the hippocampal slice preparation in the study of Alzheimer's disease

23 February 2021

1 reference

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The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.

23 February 2021

1 reference

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Beta-amyloid expression, release and extracellular deposition in aged rat brain slices

23 February 2021

1 reference

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Predominant neuritic pathology induced by viral overexpression of alpha-synuclein in cell culture

23 February 2021

1 reference

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Beta-amyloid peptide toxicity in organotypic hippocampal slice culture involves Akt/PKB, GSK-3beta, and PTEN.

23 February 2021

1 reference

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Increased tau phosphorylation at the Ser396 epitope after amyloid beta-exposure in organotypic cultures

23 February 2021

1 reference

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ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures

23 February 2021

1 reference

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Early signs of motoneuron vulnerability in a disease model system: Characterization of transverse slice cultures of spinal cord isolated from embryonic ALS mice.

23 February 2021

1 reference

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Cytoskeletal, synaptic, and nuclear protein changes associated with rat interface organotypic hippocampal slice culture development

23 February 2021

1 reference

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Organotypic hippocampal slice cultures for studies of brain damage, neuroprotection and neurorepair

23 February 2021

1 reference

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Organotypic cultures as tools for functional screening in the CNS.

23 February 2021

1 reference

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RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

23 February 2021

1 reference

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Role of LRP in TGFbeta2-mediated neuronal uptake of Abeta and effects on memory.

23 February 2021

1 reference

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Functional validation of adult hippocampal organotypic cultures as an in vitro model of brain injury.

23 February 2021

1 reference

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Complement C1q expression induced by Abeta in rat hippocampal organotypic slice cultures

23 February 2021

1 reference

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Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

23 February 2021

1 reference

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

23 February 2021

1 reference

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Development of rat CA1 neurones in acute versus organotypic slices: role of experience in synaptic morphology and activity.

23 February 2021

1 reference

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Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms

23 February 2021

1 reference

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Post-mortem brain tissue cultures from elderly control subjects and patients with a neurodegenerative disease

23 February 2021

1 reference

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Organotypic slice cultures from transgenic mice as disease model systems.

23 February 2021

1 reference

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Organotypic brain-slice cultures from adult rats: approaches for a prolonged culture time

23 February 2021

1 reference

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Adeno-associated virus effectively mediates conditional gene modification in the brain

23 February 2021

1 reference

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Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6889333

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6889333

Long-term maintenance of mature hippocampal slices in vitro

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6889333

Glial fibrillary acidic protein is necessary for mature astrocytes to react to beta-amyloid

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6889333

Markers for neuronal degeneration in organotypic slice cultures

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6889333

Postnatal expression pattern of calcium-binding proteins in organotypic thalamic cultures and in the dorsal thalamus in vivo

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6889333

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6889333

Resting microglial cells in vitro: analysis of morphology and adhesion molecule expression in organotypic hippocampal slice cultures

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6889333

beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6889333

Long-term hippocampal slices: a model system for investigating synaptic mechanisms and pathologic processes

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6889333

Identification of cell types in rat hippocampal slices maintained in organotypic cultures.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6889333

Organotypic monolayer cultures of nervous tissue

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6889333

Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6889333

Proliferation and differentiation of glial fibrillary acidic protein-immunoreactive glial cells in organotypic slice cultures of rat hippocampus

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6889333

Human fetal central nervous system organotypic cultures

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6889333

Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6889333

A simple method for organotypic cultures of nervous tissue

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6889333

Effect of beta amyloid peptides on neurons in hippocampal slice cultures

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6889333

10.1186/S13024-019-0346-0

23 February 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31791377%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31791377%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

PubMed publication ID

31791377

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31791377%20AND%20SRC:MED&resulttype=core&format=json