The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy. (Q46804886)

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English	The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.	scientific article

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1 January 2020

The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy (English)

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1 January 2020

protein structure

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Eckhard Mandelkow

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Eckhard Mandelkow

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25 December 2017

Eva-Maria Mandelkow

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Eva-Maria Mandelkow

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25 December 2017

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Maria-Magdalena Mocanu

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1 January 2020

Astrid Nissen

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Katrin Eckermann

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Inna Khlistunova

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Jacek Biernat

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Dagmar Drexler

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1 January 2020

Olga Petrova

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Kai Schönig

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Hermann Bujard

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1 January 2020

Lepu Zhou

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1 January 2020

Gabriele Rune

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1 January 2020

Eckhard Mandelkow

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1 January 2020

Eva-Maria Mandelkow

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1 January 2020

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1 January 2008

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1 January 2020

Journal of Neuroscience

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1 January 2020

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1 January 2020

3

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1 January 2020

737-748

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1 January 2020

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence requirements for formation of conformational variants of tau similar to those found in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assembly of paired helical filaments from mouse tau: implications for the neurofibrillary pathology in transgenic mouse models for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Going new places using an old MAP: tau, microtubules and human neurodegenerative disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegenerative tauopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative analysis of an improved thioflavin-s stain, Gallyas silver stain, and immunohistochemistry for neurofibrillary tangle demonstration on the same sections.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen up-regulates estrogen receptor alpha and synaptophysin in slice cultures of rat hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure, stability, and aggregation of paired helical filaments from tau protein and FTDP-17 mutants probed by tryptophan scanning mutagenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease is a synaptic failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic slaughter in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subcellular distribution of spinophilin immunolabeling in primate prefrontal cortex: localization to and within dendritic spines

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Median raphe mediates estrogenic effects to the hippocampus in female rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal synapses depend on hippocampal estrogen synthesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau, tangles, and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau phosphorylation: physiological and pathological consequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau alteration and neuronal degeneration in tauopathies: mechanisms and models

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: Abeta, tau and synaptic dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau suppression in a neurodegenerative mouse model improves memory function

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L).

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global hairpin folding of tau in solution

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A decade of modeling Alzheimer's disease in transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demonstration of Amyloid Deposits and Neurofibrillary Changes in Whole Brain Sections

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau protein, the paired helical filament and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential therapeutic applications of autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural principles of tau and the paired helical filaments of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A decade of tau transgenic animal models and beyond

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The distribution of tau in the mammalian central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-regulation of two gene activities by tetracycline via a bidirectional promoter.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of memory formation through regulated expression of a CaMKII transgene

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199773

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1523/JNEUROSCI.2824-07.2008

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1 January 2020

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1 January 2020

PubMed publication ID

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1 January 2020

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