Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease. (Q42701855)

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2 February 2020

title

Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease (English)

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2 February 2020

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2 February 2020

Donald C Lo

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2 February 2020

Steven P Braithwaite

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2 February 2020

Dong Ning He

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2 February 2020

Mei-Li A Sung

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2 February 2020

Seongeon Cho

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2 February 2020

Lynn Resnick

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2 February 2020

Michael M Monaghan

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2 February 2020

Warren D Hirst

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2 February 2020

Christian Essrich

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2 February 2020

Peter H Reinhart

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2 February 2020

publication date

6 May 2010

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2 February 2020

published in

Neurobiology of Disease

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2 February 2020

volume

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issue

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2 February 2020

page(s)

311-317

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CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease

2 February 2020

cites work

1 reference

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IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.

27 May 2018

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Oxidative stress promotes JNK-dependent amyloidogenic processing of normally expressed human APP by differential modification of alpha-, beta- and gamma-secretase expression.

27 May 2018

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Anti-inflammatory and immune therapy for Alzheimer's disease: current status and future directions

27 May 2018

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Update of the stroke therapy academic industry roundtable preclinical recommendations

27 May 2018

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JNK regulates APP cleavage and degradation in a model of Alzheimer's disease.

27 May 2018

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Accumulated amyloid-beta peptide and hyperphosphorylated tau protein: relationship and links in Alzheimer's disease

27 May 2018

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JNK signaling in apoptosis

27 May 2018

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Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity

27 May 2018

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Disease-modifying therapies in Alzheimer's disease

27 May 2018

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Tau-based treatment strategies in neurodegenerative diseases

27 May 2018

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New therapeutic targets in the neurovascular pathway in Alzheimer's disease

27 May 2018

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Brain slices as models for neurodegenerative disease and screening platforms to identify novel therapeutics

27 May 2018

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Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase

27 May 2018

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Neuronal transfection using particle-mediated gene transfer

27 May 2018

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JNK and ERK1/2 pathways have a dual opposite effect on the expression of BACE1.

27 May 2018

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Amyloid beta-protein precursor juxtamembrane domain regulates specificity of gamma-secretase-dependent cleavages

27 May 2018

1 reference

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Selective inhibitors of death in mutant huntingtin cells

27 May 2018

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Cardiac glycosides provide neuroprotection against ischemic stroke: discovery by a brain slice-based compound screening platform

27 May 2018

1 reference

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Proteolytic mechanisms in amyloid-beta metabolism: therapeutic implications for Alzheimer's disease

27 May 2018

1 reference

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Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity.

27 May 2018

1 reference

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FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction

27 May 2018

1 reference

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Identification of the critical features of a small peptide inhibitor of JNK activity

27 May 2018

1 reference

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SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

27 May 2018

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Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

27 May 2018

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Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

27 May 2018

1 reference

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The primary structure and heterogeneity of tau protein from mouse brain

27 May 2018

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Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains

27 May 2018

1 reference

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Directed neural lineage differentiation of adult hippocampal progenitor cells via modulation of hippocampal cholinergic neurostimulating peptide precursor expression

27 May 2018

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The JNK pathway amplifies and drives subcellular changes in tau phosphorylation

16 August 2018

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Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors

16 August 2018

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Specific pathophysiological functions of JNK isoforms in the brain

16 August 2018

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Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK).

16 August 2018

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A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia

16 August 2018

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Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition.

16 August 2018

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Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.

16 August 2018

1 reference

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Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth.

16 August 2018

1 reference

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Human c-Jun N-terminal kinase expression and activation in the nervous system

16 August 2018

1 reference

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Stress-activated protein kinase/c-jun N-terminal kinase phosphorylates tau protein

16 August 2018

1 reference

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Expression of stress-activated kinases c-Jun N-terminal kinase (SAPK/JNK-P) and p38 kinase (p38-P), and tau hyperphosphorylation in neurites surrounding betaA plaques in APP Tg2576 mice

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20451607

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The TAT-JNK inhibitor peptide interferes with beta amyloid protein stability

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20451607

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.NBD.2010.04.015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20451607%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20451607%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

PubMed publication ID

20451607

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20451607%20AND%20SRC:MED&resulttype=core&format=json