GATA2 +9.5 enhancer: from principles of hematopoiesis to genetic diagnosis in precision medicine (Q90605249)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32205587%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

title

GATA2 +9.5 enhancer: from principles of hematopoiesis to genetic diagnosis in precision medicine (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32205587%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

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Emery H Bresnick

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32205587%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

Alexandra A Soukup

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15 April 2020

publication date

1 May 2020

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Current Opinion in Hematology

15 April 2020

published in

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15 April 2020

volume

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15 April 2020

issue

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15 April 2020

page(s)

163-171

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Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells

15 April 2020

cites work

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The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins

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Enforced expression of the GATA-2 transcription factor blocks normal hematopoiesis.

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SCL and associated proteins distinguish active from repressive GATA transcription factor complexes

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GATA Switches as Developmental Drivers

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A Single cis Element Maintains Repression of the Key Developmental Regulator Gata2

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Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome.

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Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency.

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Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome)

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Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia

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Overexpression of GATA2 predicts an adverse prognosis for patients with acute myeloid leukemia and it is associated with distinct molecular abnormalities.

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Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature

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UG4 enhancer-driven GATA-2 and bone morphogenetic protein 4 complementation remedies the CAKUT phenotype in Gata2 hypomorphic mutant mice

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High GATA2 expression is a poor prognostic marker in pediatric acute myeloid leukemia

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Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity

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GATA2 haploinsufficiency caused by mutations in a conserved intronic element leads to MonoMAC syndrome

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Acquired ASXL1 mutations are common in patients with inherited GATA2 mutations and correlate with myeloid transformation

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GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity.

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Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo

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Gata2 is required for HSC generation and survival

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Epigenetic regulation of GATA2 and its impact on normal karyotype acute myeloid leukemia.

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Conversion of danger signals into cytokine signals by hematopoietic stem and progenitor cells for regulation of stress-induced hematopoiesis

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Mechanism governing a stem cell-generating cis-regulatory element

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Molecular basis of crosstalk between oncogenic Ras and the master regulator of hematopoiesis GATA-2

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GATA2 deficiency-associated bone marrow disorder differs from idiopathic aplastic anemia.

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Induction of hematopoietic and endothelial cell program orchestrated by ETS transcription factor ER71/ETV2.

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Hematopoietic Signaling Mechanism Revealed from a Stem/Progenitor Cell Cistrome

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Cis-regulatory mechanisms governing stem and progenitor cell transitions

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Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents

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The Hematopoietic Stem and Progenitor Cell Cistrome: GATA Factor-Dependent cis-Regulatory Mechanisms

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ETS Transcription Factor ETV2/ER71/Etsrp in Hematopoietic and Vascular Development

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SCL/TAL1 in Hematopoiesis and Cellular Reprogramming

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12 December 2020

Acute lymphoblastic leukemia in a patient with MonoMAC syndrome/GATA2 haploinsufficiency

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12 December 2020

Exome sequencing identifies highly recurrent somatic GATA2 and CEBPA mutations in acute erythroid leukemia

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12 December 2020

GATA Factor-Dependent Positive-Feedback Circuit in Acute Myeloid Leukemia Cells

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12 December 2020

The GATA factor revolution in hematology

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12 December 2020

Roles of the RUNX1 Enhancer in Normal Hematopoiesis and Leukemogenesis

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12 December 2020

ETV2/ER71 regulates hematopoietic regeneration by promoting hematopoietic stem cell proliferation.

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12 December 2020

Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes.

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12 December 2020

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

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12 December 2020

Inflammation: a key regulator of hematopoietic stem cell fate in health and disease

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12 December 2020

Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program

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12 December 2020

Somatic mutations in children with GATA2-associated myelodysplastic syndrome who lack other features of GATA2 deficiency

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12 December 2020

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells

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12 December 2020

From haematopoietic stem cells to complex differentiation landscapes.

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12 December 2020

Allogeneic Hematopoietic Stem-Cell Transplantation for GATA2 Deficiency Using a Busulfan-Based Regimen.

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Natural history of GATA2 deficiency in a survey of 79 French and Belgian patients

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GATA2 monoallelic expression underlies reduced penetrance in inherited GATA2-mutated MDS/AML

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12 December 2020

GATA2 Is Dispensable for Specification of Hemogenic Endothelium but Promotes Endothelial-to-Hematopoietic Transition

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12 December 2020

Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis

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12 December 2020

Allogeneic hematopoietic cell transplantation in patients with GATA2 deficiency—a case report and comprehensive review of the literature

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12 December 2020

GATA2 zinc finger 1 mutations are associated with distinct clinico-biological features and outcomes different from GATA2 zinc finger 2 mutations in adult acute myeloid leukemia

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12 December 2020

Human leukemia mutations corrupt but do not abrogate GATA-2 function

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12 December 2020

GATA2 deficiency and human hematopoietic development modeled using induced pluripotent stem cells

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12 December 2020

MDS-associated mutations in germline GATA2 mutated patients with hematologic manifestations

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12 December 2020

Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer

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12 December 2020

GATA2 hypomorphism induces chronic myelomonocytic leukemia in mice

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12 December 2020

Gata2 as a Crucial Regulator of Stem Cells in Adult Hematopoiesis and Acute Myeloid Leukemia

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To be red or white: lineage commitment and maintenance of the hematopoietic system by the "inner myeloid"

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GATA2 deficiency and haematopoietic stem cell transplantation: challenges for the clinical practitioner

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Inducible Forward Programming of Human Pluripotent Stem Cells to Hemato-endothelial Progenitor Cells with Hematopoietic Progenitor Potential

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Combining gene variants with clinical characteristics improves outcome prediction in Chinese patients with myelodysplastic syndromes

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12 December 2020