MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis (Q37608924)

21 August 2017

MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis (English)

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21 August 2017

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Ricardo Saldaña-Meyer

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13 June 2020

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13 June 2020

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13 June 2020

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13 June 2020

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Leonard I Zon

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13 June 2020

Iannis Aifantis

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Leonela Amoasii

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Piotr Sicinski

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13 June 2020

Danny Reinberg

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Clarisse Kayembe

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Beatriz Aranda-Orgilles

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Beatriz Aranda-Orgilles

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13 June 2020

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Ramya Raviram

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Eric Wang

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13 June 2020

Anne Fassl

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13 June 2020

Jasper Mullenders

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13 June 2020

María Guillamot

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13 June 2020

María Sánchez-Díaz

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13 June 2020

Kun Wang

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Avik Choudhuri

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Markus Schober

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13 June 2020

Heinrich Schrewe

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13 June 2020

language of work or name

English

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publication date

24 August 2016

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21 August 2017

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13 June 2020

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13 June 2020

page(s)

784-799

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YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers

13 June 2020

cites work

1 reference

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Mediator kinase inhibition further activates super-enhancer-associated genes in AML

23 August 2017

1 reference

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The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development

23 August 2017

1 reference

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Med12 gain-of-function mutation causes leiomyomas and genomic instability.

23 August 2017

1 reference

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The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis

23 August 2017

1 reference

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The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.

23 August 2017

1 reference

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The Mediator complex: a central integrator of transcription

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia

23 August 2017

1 reference

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Cyclin C is a haploinsufficient tumour suppressor

23 August 2017

1 reference

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Immunogenetics. Chromatin state dynamics during blood formation

23 August 2017

1 reference

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Subunit architecture and functional modular rearrangements of the transcriptional mediator complex

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Master transcription factors and mediator establish super-enhancers at key cell identity genes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Activating RNAs associate with Mediator to enhance chromatin architecture and transcription

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Evolution and impact of subclonal mutations in chronic lymphocytic leukemia

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

A cardiac microRNA governs systemic energy homeostasis by regulation of MED13

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Topological domains in mammalian genomes identified by analysis of chromatin interactions

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

ChromHMM: automating chromatin-state discovery and characterization

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Mediator subunit 12 is required for neutrophil development in zebrafish

23 August 2017

1 reference

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Human mediator subunit MED26 functions as a docking site for transcription elongation factors

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Long noncoding RNAs with enhancer-like function in human cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Mediator and cohesin connect gene expression and chromatin architecture

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Inducible gene expression: diverse regulatory mechanisms

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex

23 August 2017

1 reference

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Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7

23 August 2017

1 reference

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Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13.

23 August 2017

1 reference

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Hematopoiesis: an evolving paradigm for stem cell biology

23 August 2017

1 reference

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FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

23 August 2017

1 reference

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Restoration of p53 function leads to tumour regression in vivo

23 August 2017

1 reference

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Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors

23 August 2017

1 reference

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Biological control through regulated transcriptional coactivators

23 August 2017

1 reference

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Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins

23 August 2017

1 reference

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TFIIH is negatively regulated by cdk8-containing mediator complexes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Expression of the LIM-homeobox gene LH2 generates immortalized steel factor-dependent multipotent hematopoietic precursors.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Inducible gene targeting in mice

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Hallmarks of pluripotency

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Transcription factors: from enhancer binding to developmental control

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Interactions between subunits of the Mediator complex with gene-specific transcription factors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Mediator requirement for both recruitment and postrecruitment steps in transcription initiation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Extracting biological meaning from large gene lists with DAVID.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

Hematopoietic stem cells need two signals to prevent apoptosis; BCL-2 can provide one of these, Kitl/c-Kit signaling the other

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5268820

10.1016/J.STEM.2016.08.004

1 September 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27570068%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27570068%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

PubMed publication ID

27570068

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27570068%20AND%20SRC:MED&resulttype=core&format=json